2019 American Transplant Congress » Poster Session D: Tolerance / Immune Deviation

6:00pm-7:00pm

A Novel Method for Ex Vivo Treg Expansion via Human iNKT Cell Activation

R. Ishii¹, I. Masako¹, H. Katsumata¹, T. Kanzawa¹, T. Yamakawa¹, H. Ishigooka¹, T. Hirai¹, K. Saiga¹, M. Okumi¹, Y. Ishii², K. Tanabe¹

6:00pm-7:00pm

Ablation of Interferon Regulatory Factor 4 in T Cells Induces “Memory” of Transplant Tolerance That is Irreversible by Immune Checkpoint Blockade

H. Zhang¹, J. Wu², D. Zou³, W. Chen³

6:00pm-7:00pm

Acquired Resistance to Transplantation Tolerance as a Result of Prior Pregnancy Requires B Cells

D. V. Tran, A. N. Suah, S. Khiew, J. S. Young, Q. Wang, D. Yin, M. Alegre, A. S. Chong

6:00pm-7:00pm

Allograft Survival is Influenced by Gut Microbiota-Dependent Modulation of Innate Immunity

V. Saxena¹, Y. Xiong¹, L. Hittle¹, L. Li¹, T. Simon², W. Piao¹, C. C. Brinkman¹, E. M. Smyth¹, T. Zhang¹, C. Wagner¹, C. M. Palusckievicz¹, W. F. Fricke³, E. F. Mongodin¹, J. S. Bromberg¹

6:00pm-7:00pm

Analysis and Regulation of Immune Reaction in the Transplantation from MHC Homozygous Donors to Heterozygous Recipients with Minor Antigen Mismatches

T. Murata, H. Wada, R. Otsuka, H. Tsuji, A. Sasaki, M. Baghdadi, K. Seino

6:00pm-7:00pm

B7H1 Expression is Crucial for Tolerance Induction in Mouse Liver Transplantation

M. Morita¹, S. Datta¹, C. Miller², T. Hamilton¹, K. Hashimoto³

6:00pm-7:00pm

Bcl-2/Bcl-xL Inhibition by Navitoclax vs. Bcl-2 Alone Inhibition by Venetoclax for Induction of Mixed Chimerism in Non-Human Primates

H. Sasaki¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, I. Rosales², B. Cosimi¹, P. Cippa³, T. Fehr³, T. Kawai¹

6:00pm-7:00pm

Chimeric Allografts Induced by Stem Cell Mobilizing Agents in a Mouse Model of Kidney Transplantation: Role of CD133 Stem Cells

J. Zhou, l. Qi, A. Ahmadi, R. Wesson, A. Cameron, J. Burdick, Z. Sun

6:00pm-7:00pm

Circulating Exosomes with Cardiac Self-Antigens (Cardiac Myosin and Vimentin) and De Novo Development of Antibodies to Cardiac Self-Antigens Precedes Chronic Cardiac Allograft Rejection

R. Ravichandran, Y. Itabashi, W. Liu, T. Mohanakumar

6:00pm-7:00pm

Comparative Use of Single mTOR vs Dual mTOR/PI3K Inhibition in Regulatory T Cell Expansion for Clinical Application in Transplantation

R. Gedaly-Eidelman, F. Marti, L. Turcios, E. Chacon, D. Valvi

6:00pm-7:00pm

Deficiency of the Transcription Factor Satb1 in T Cells Promotes Solid Organ Allograft Survival

P. K. Gupta¹, M. L. Miller², L. Chen¹, Y. Wang¹, J. Conejo-Garcia³, A. Chong¹, M. Alegre¹

6:00pm-7:00pm

Depleting Laminin α5 in Lymph Node Stromal Cells Promotes Transplant Tolerance

L. Li, M. Shirkey, W. Piao, Y. Xiong, V. Saxena, T. Zhang, N. Toney, C. Paluskievicz, J. S. Bromberg

6:00pm-7:00pm

Dichotomous Role Of Donor T Cells In The Efficacy Of Tolerogenic Therapies For Transplant Rejection

M. Iglesias Lozano, D. Bibicheff, M. Chicco, G. Brandacher, G. Raimondi

6:00pm-7:00pm

Donor Brain Death Affects Tolerance Induction in Non-Human Primates

W. Sommer¹, J. M. O², K. B. Pruner³, J. T. Paster³, A. Bean³, A. Dehnadi³, I. M. Hanekamp³, I. Rosales⁴, R. N. Smith⁴, R. B. Colvin⁴, G. Benichou³, J. S. Allan³, T. Kawai³, J. C. Madsen⁵

6:00pm-7:00pm

ECDI-Treated Donor Leukocytes in Primate Cardiac Allograft Recipients

Z. Alikhassy Habibabady¹, T. Zhang², W. Sun², X. Cheng², L. Burdorf¹, I. Tatarov², S. Sendil², I. Behroozfard², B. Cerel¹, D. Parsell², R. N. Pierson III¹, X. Luo³, A. M. Azimzadeh¹

6:00pm-7:00pm

Endogenous Erythropoietin is Required for Spontaneous Acceptance of Murine Renal Allografts

J. Horwitz, P. Cravedi, P. Heeger

6:00pm-7:00pm

Generation of Human/Pig Hybrid Thymus to Achieve Immune Tolerance to Pig Antigens with Optimal Immune Function

M. Khosravi Maharlooei, H. Li, M. Holzl, A. Vecchione, A. Misra, A. Ruiz, R. Madley, G. Nauman, N. Danzl, G. Zhao, K. Yamada, M. Sykes

6:00pm-7:00pm

Heart En Bloc Thymus Cotransplantation in NHPs

J. O¹, W. Sommer², K. Pruner³, J. T. Paster⁴, I. M. Hanekamp¹, A. Dehnadi¹, I. Rosales¹, R. N. Smith¹, R. B. Colvin¹, G. Benichou¹, J. S. Allan¹, J. C. Madsen¹

6:00pm-7:00pm

IL-21 Induces the Transformation of Th Cell Subsets in Acute Rejection after Kidney Transplantation

H. Deng, R. Wang, J. Shen, J. Chen

6:00pm-7:00pm

Immunologically Tolerant Liver Transplant Recipients Are Characterized by Donor-Specific Hypo Responsiveness of Circulating T-cells

A. A. Duizendstra¹, R. J. Knegt de¹, M. G. Betjes², M. P. Peppelenbosch¹, N. H. Litjens², J. Kwekkeboom¹

6:00pm-7:00pm

In Vivo/In Situ Behaviour of Allogeneic Spleen versus Bone Marrow Cells in Wild-Type Neonatal Mice: Insights into Robust Transplant Tolerance Induction

R. A. Bascom, K. Tao, L. J. West

6:00pm-7:00pm

Increased Frequency of Myeloid-Derived Suppressor Cells Contributing to Prolong Skin Allograft Survival in Aged Mice

W. Lee, Y. Wang, T. Wu, C. Cheng, C. Lee, T. Wu, H. Chou, K. Chan

6:00pm-7:00pm

Kidney Allografts Induce Systemic Tolerance of Heart Allografts and is Dependent on Foxp3+ Cells

C. Yang¹, J. Ge¹, P. S. Russell¹, J. C. Madsen¹, A. Alessandrini¹, R. B. Colvin²

6:00pm-7:00pm

MHC Cross-Dressing in Mixed Hematopoietic Chimerism

B. Gonzalez Nolasco¹, M. Wang¹, W. Orent¹, A. Prunevieille¹, K. Pruner¹, J. O¹, J. Paster¹, J. C. Madsen², G. Benichou¹

6:00pm-7:00pm

Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice

Y. Huang, H. Xu, Y. Wen, S. Ildstad

6:00pm-7:00pm

Role of RIPK3 in Chronic Rejection Following Human Lung Transplantation

S. Angara, R. Ravichandran, H. Sodawalla, M. Smith, R. Bremner, T. Mohanakumar

6:00pm-7:00pm

Superiority of Donor-Specifically vs. Polyclonally Expanded Regulatory T Cells in Controlling Graft Rejection in the NSG Mouse Human Skin Graft Model

J. H. Voss¹, F. Zheng¹, M. D. Jendrisak², J. R. Leventhal¹, Z. J. Zhang¹, J. M. Mathew¹

6:00pm-7:00pm

T Cell-Intrinsic Dysfunction in Donor-Specific Transplantation Tolerance

C. M. McIntosh¹, M. L. Miller², Y. Wang¹, A. Chong³, M. Alegre¹

6:00pm-7:00pm

The Effects of Chronic Kidney Disease on Antiviral T Cell Response

R. L. Crepeau¹, H. Li², L. P. Daley-Bauer³, M. L. Ford¹, P. D. Winterberg²

6:00pm-7:00pm

Tolerance to ABO A-Antigen Following Treatment of Infant Mice with A-Expressing MHC-Identical Erythrocytes

B. Motyka¹, J. Fersovich¹, M. Sulzer¹, I. Adam¹, J. Pearcey¹, K. Tao¹, C. W. Cairo², P. J. Cowan³, L. J. West¹