2017 American Transplant Congress » Poster Session C: Tolerance/Immune Regulation

6:00pm-7:00pm

A Composite Score Associated with Spontaneous Operational Tolerance in Kidney Transplant Recipients.

R. Danger,¹ M. Chesneau,¹ C. Paul,¹ P. Guérif,¹ M. Durand,¹ K. Newell,² S. Kanaparthi,³ L. Turka,⁴ J.-P. Soulillou,¹ R. Houlgatte,⁵ M. Giral,^1,6 G. Ramstein,⁷ S. Brouard.^1,6

6:00pm-7:00pm

A Novel Method for iNKT Cell-Mediated Ex Vivo Treg Expansion Applied to Induce Human Transplant Tolerance.

H. Katsumata,^1,2 M. Ikemiyagi,¹ S. Miyairi,¹ R. Ishii,¹ T. Kanzawa,¹ H. Fukuda,¹ T. Hirai,¹ M. Okumi,¹ Y. Ishii,³ K. Tanabe.¹

6:00pm-7:00pm

A-Antigen (Ag)-Specific Tolerance Following A-Ag Administration to Infant Mice.

B. Motyka,¹ Y. Wang,¹ B. Lamarche,¹ I. Adam,¹ J. Pearcey,¹ K. Tao,¹ C. Cairo,² P. Cowan,³ L. West.¹

6:00pm-7:00pm

Aryl Hydrocarbon Receptor Regulates Myeloid Derived Suppressor Cells by Activating the ERK Signaling in a Murine Cardiac Transplantation Model.

T. Nakamura, K. Masuda, N. Yoshimura.

6:00pm-7:00pm

Blocked of Bat3 Expression Promotes Transplant Tolerance by Inducing IL-10 Expression in Dendritic Cells.

G. Gu, H. Hang, Q. Xia.

6:00pm-7:00pm

CD4 and CD8 T Cells: Respectively Reprogrammed and Recapitulated in the Neonate to Induce Transplant Tolerance.

R. Bascom, K. Tao, L. West.

6:00pm-7:00pm

CD4⁺CD28^null T Cells Require IL-15 & IL-21 to Become Alloresponsive.

B. Dedeoglu, N. Litjens, R. Kraaijeveld, W. Verschoor, C. Baan, M. Betjes.

6:00pm-7:00pm

CD4⁺IFN-γ⁺IL-10⁺ Regulatory Type 1 Cells Facilitate Prolongation of Graft Survival in Old Recipient Mice Treated with Rapamycin.

T. Heinbokel, M. Quante, K. Minami, A. Elkhal, S. Tullius.

6:00pm-7:00pm

CD8+ TAb-supp Cells Are Key Inhibitors of Humoral Alloimmunity by Inhibiting CD4+TFH Cells and Killing Germinal Center B Cells.

J. Zimmerer, C. Avila, S. Elzein, B. Ringwald, R. Warren, G. Bumgardner.

6:00pm-7:00pm

CTLA4-Ig in Combination with FTY720 Reduces the Frequency of Memory Alloreactive T Cells and Promotes Heart Allograft Survival in Sensitized Recipients.

S. Khiew,¹ J. Yang,¹ J. Young,¹ J. Chen,¹ Q. Wang,¹ D. Ying,¹ V. Vu,¹ M. Miller,² R. Sciammas,³ M.-L. Alegre,² A. Chong.¹

6:00pm-7:00pm

Chimerism-Related Allotolerance Is Induced by Exosome Acquisition and Reprogramming of Host Dendritic Cells.

D. Lema,¹ W. Bracamonte-Baran,² E. Jankowska-Gan,¹ F. Claas,³ J. van Rood,³ A. Mulder,³ W. Burlingham.¹

6:00pm-7:00pm

Combination Therapy of iNKT Cell Ligand and CD40-CD154 Signal Blockade Establishes Islet Allograft Tolerance in Non-Myeloablative Bone Marrow Transplant Recipients.

T. Kanzawa,¹ T. Hirai,¹ R. Ishii,¹ M. Okumi,¹ H. Ishida,¹ Y. Ishii,² K. Tanabe.¹

6:00pm-7:00pm

Dendritic Cells That Highly Express SOCS1 Induce T-Cell Hypo-Responsiveness and Prolong Islet Allograft Survival.

R. Deng, X. Lu, M. Chen, Z. Xue, X. Zhang, J. Xu, L. Wu, Y. Ma.

6:00pm-7:00pm

Does Blockade of ICOS/ICOS-L Pathway Act Synergistically with αCD40 Costimulation Pathway Blockade?

N. O'Neill, T. Zhang, X. Cheng, W. Sun, G. Braileanu, I. Tatarov, W. Hassanein, A. Azimzadeh, R. Pierson.

6:00pm-7:00pm

Ethylene Carbodiimide Fixed Donor Splenocytes Combined with α-1 Antitrypsin Induce Indefinite Donor Specific Protection to Mice Cardiac Allografts.

G. Chen, X. Lai, L. Qiu, Y. Zhao, S. Yu, J. Zhang, L. Chen.

6:00pm-7:00pm

Exosomes Containing IL35 Are Secreted by Donor-Specific Regulatory T Cells and Cause Linked-Suppression.

Y. Tomita,¹ W. Bracamonte-Baran,¹ E. Jankowska-Gan,¹ Q. Zhang,² D. Vignali,² W. Burlingham.¹

6:00pm-7:00pm

Expansion, Function and Clonotypic Analysis of Human Alloreactive Treg Stimulated with Different Dendritic Cell Populations or CD40L-Stimulated B Cells.

H. Zhang,¹ Y. Zhao,¹ Q. Tang,³ A. Thomson.^1,2

6:00pm-7:00pm

Functional Mystacial Pad Allograft Tolerance Induced and Maintained by Vascularized Bone Marrow Transplant.

C.-H. Lin,^1,2 M. Anggelia,^1,2 C.-J. Wen,¹ W.-Y. Chuang,³ H.-Y. Cheng,¹ C.-H. Lin,^1,2 G. Brandacher.⁴

6:00pm-7:00pm

Heat Shock Protein 90 Inhibitor, 17DMAG Suppresses Acute Allograft Rejection and Prolongs Allograft Survival in Solid Organ Transplantation.

T. Maehana, T. Tanaka, N. Masumori.

6:00pm-7:00pm

Human Regulatory T Cells Undergo Self-Inflicted Damage via Granzyme Pathways Upon Activation.

J. Assaker, E. Karreci, F. Dotiwala, S. Routray, A. Kurdi, A. Mihali, T. Borges, A. Chandraker, L. Riella, R. Abdi, J. Lieberman, J. Azzi.

6:00pm-7:00pm

IL-33 Enhances the Ability of Dendritic Cells to Expand Human Regulatory T Cells.

Y. Zhao,¹ H. Zhang,¹ L. Mathews,¹ H. Turnquist,^1,2 A. Thomson.^1,2

6:00pm-7:00pm

Increased Expression of Fibrillin-1 and Presence of Fibroblastic Reticular Cells in Treg-Rich Organized Lymphoid Structures (TOLS) of Accepted Kidney Allografts.

A. Ayyar, C. Yang, D. Ndishabandi, R. White, P. Russell, J. Madsen, R. Colvin, A. Alessandrini.

6:00pm-7:00pm

Induction of Durable Mixed Hematopoietic Chimerism and Immune Tolerance in Non-Human Primates.

P. Alonso-Guallart,¹ R. Duran-Struuck,¹ J. Stern,¹ S. Kofman,¹ M. Danton,¹ J. Zitsman,¹ Y. Kato,¹ E. Berglund,¹ H. Sondermeijer,¹ A. McMurchy,² M. Levings,² M. Sykes,¹ A. Griesemer.¹

6:00pm-7:00pm

Induction of Tolerance to Renal Allografts in Non Human Primates by Concomitant Donor-Matched Vascularized Osteomyocutaneous Allotransplantation.

F. Zhong,¹ G. Zhao,² Y. Wang,³ J. Jiang,³ Y. Wang,¹ S. Ye,¹ S. Tao,¹ L. Cai,¹ X. Wang,¹ Q. Ye,¹ G. Chen,² X. Zheng.¹

6:00pm-7:00pm

Liver Targeted Expression of a Single Allogeneic MHC I Molecule Promotes Tolerance to Pancreatic Islet Allograft by Inducing Specific CD8+ Regulatory T Cells in Mice.

V. Le Guen,^1,2 J.-P. Judor,^1,2 V. Gauttier,^1,2 N. Ferry,³ J.-P. Soulillou,^1,2 S. Brouard,^1,2 S. Conchon.^1,2

6:00pm-7:00pm

Liver Transplantation Tolerance Using Outbred Mice.

M. Morita,¹ C. Miller,² J. Fung,³ L. Lu,^1,2 S. Qian.^1,2

6:00pm-7:00pm

Loss of Bat3 Could Promote Transplant Tolerance by Regulating CD4 ⁺ T Cells Function.

G. Gu, H. Hang, Q. Xia.

6:00pm-7:00pm

MERTK Mediates Transplantation Tolerance via Inhibition of TBK1 Phosphorylation and IFN-a Production.

L. Zhang,¹ M. DeBerge,² X. Zhang,³ J. Wang,³ Z. Zhang,³ E. Thorp,² X. Luo.^1,2,3

6:00pm-7:00pm

Operational Tolerance in Intestinal Transplantation: A Proven Possibility.

B. Houlihan,¹ P. Cha,^1,2 C. Cosentino,^1,2 J. Kaiser,^1,2 A. Shukla,¹ J. Hawksworth,^1,2 C. Matsumoto,¹ T. Fishbein,¹ A. Kroemer.¹

6:00pm-7:00pm

Preventing Alloimmune Rejection in Heart Transplantation by Tolerogenic Dendritic Cells Induced by GDF15 Through Up-Regulation of IDO and Inhibition of the NFκB Signalling Pathway.

Y. Zhang,^1,3 G. Zhang,¹ L. Moszczynski,¹ D. Zhao,^1,3 P. Abulizi,¹ D. Quan,² T. Mele,² K. Liu,³ X. Zheng.^1,2

6:00pm-7:00pm

Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity.

C. Yang, B. Peng, M. Xu, T. Zhu.

6:00pm-7:00pm

The Intragraft Vascularized Bone Marrow Component and Recipient T Regulatory Cells Facilitate Tolerance Induction After Post Transplant High Dose Cyclophosphamide Treatment in VCA.

G. Furtmüller, B. Oh, M. Fryer, S. Ganguly, V. Malek, X. Zhou, J. Dodd-o, G. Raimondi, D. Cooney, C. Brayton, W. Lee, L. Luznik, G. Brandacher.

6:00pm-7:00pm

The Transcription Factor Batf and IRF1 Controls IL-10/IL-27 Expression in Dendritic Cells and Transplant Tolerance Induction.

G. Gu, H. Hang, Q. Xia.

6:00pm-7:00pm

Tolerogenic Potential, Migratory Pathways, Engraftment and Long-Term Survival of Human Hematopoietic Chimeric Cells – A Novel Strategy to Induce Tolerance in Transplantation.

M. Siemionow, E. Bryndza Tfaily, E. Szilagyi, J. Cwykiel, S. Uygur, M. Czerwinski.

6:00pm-7:00pm

Two Months Delayed Induction of Mixed Chimerism After Heart and Kidney Cotransplantation in Nonhuman Primates.

K. Huh,¹ W. Sommer,¹ K. Robinson,¹ X. Wu,¹ J. Paster,¹ I. Hanekamp,¹ A. Dehnadi,¹ T. Kawai,^1,2 R. Smith,³ R. Colvin,^1,3 G. Benichou,¹ J. Madsen.^1,4

6:00pm-7:00pm

Which Tr1 Is Better for Transplant Tolerance Induction: Comparing the Tr1 Generated by IL-27 or TGF-βplus IL-27.

G. Gu, H. Hang, Q. Xia.