2015 American Transplant Congress » Poster Session C: Antigen Presenting Cells in Alloimmune Responses/B Cells and Antibody in Alloimmune Responses

Date: Monday, May 4, 2015

Time: 5:30pm-6:30pm

Location: Exhibit Hall E

Session Type: Poster Session

Meeting: 2015 American Transplant Congress

5:30pm-6:30pm: Donor Dendritic Cells – Potential New Therapeutic Target in Transplantation

T. Ueno,^1,2,3 M. Yeung,¹ M. McGrath,¹ H. Iwamoto,³ Y. Nakamura,³ O. Konnno,³ Y. Kihara,³ T. Yokoyama,³ S. Ono,³ T. Ikeda,³ S. Kawachi,³ B. Ibrahim,¹ A. Chandraker.¹

5:30pm-6:30pm: Activation and Sequestration of Platelets During Xenogeneic GalTKO.hCD46 Pig Lung Perfusion Is Primarily Mediated By GPIb, GPIIb/IIIa, and VWF

L. Burdorf,¹ A. Riner,¹ A. Shah,¹ E. Schwartz,¹ K. Quinn,¹ E. Kang,¹ E. Sievert,¹ E. Rybak,¹ D. Harris,¹ T. Zhang,¹ D. Parsell,¹ X. Cheng,¹ G. Braileanu,¹ S. De Meyer,² I. Salles,² H. Deckmyn,² C. Phelps,³ D. Ayares,³ R. Pierson III,¹ A. Azimzadeh.¹

5:30pm-6:30pm: Anti-LG3 Antibodies Aggravate Ischemia-Reperfusion Injury

B. Yang,¹ K. Hamelin,¹ L. Pomerleau,¹ J. Peng,¹ J. Tremblay,¹ N. Patey,² M.-J. Hébert.¹

5:30pm-6:30pm: Antibody-Induced Platelet Activation Increases Allograft Hyaluronan Fragmentation

H.-H. Kuo,¹ R. Fan,¹ N. Dvorina,¹ C. De La Motte,² W. Baldwin.¹

5:30pm-6:30pm: Antibody-Mediated Rejection Is Associated With Higher Serum Levels of CXCL13 and CCL21 in Renal Transplant Patients and Altered By Bortezomib/Rituximab Treatment

M. Duerr,¹ K. Daemen,² J. Keil,² K. Budde,¹ C. Falk.²

5:30pm-6:30pm: B-Cell Activation in Acute Kidney Injury and Delayed Graft Function

M. Schiffer,¹ F. Wiehler,¹ R. Song,¹ R. Chen,¹ L. Schiffer,¹ M. Mengel,² H. Haller,¹ F. Gueler.¹

5:30pm-6:30pm: Blocking CD40/CD154 Co-Stimulation Prevents Acute Antibody-Mediated Renal Allograft Rejection Induced by Memory CD4 T Cells

V. Gorbacheva, R. Fan, A. Valujskikh.

5:30pm-6:30pm: Combined Anti-IL6R and CTLA4Ig Therapy Attenuates Recall Alloantibody Responses in a Mouse Model of HLA Sensitization

N.-N. Chai, G. Wu, I. Kim, A. Klein, S. Jordan.

5:30pm-6:30pm: Distinct Subtypes of Rejection in a Novel Non Human Primate Model of Sensitization

C. Burghuber,^1,2 J. Kwun,^1,3 F. Leopardi,³ A. Gibby,¹ A. Farris,¹ N. Iwakoshi,¹ S. Knechtle.^1,3

5:30pm-6:30pm: Host NK Cell Allorecognition of Passenger Donor Lymphocytes Within Allografts Is Essential for Preventing Augmentation of Recipient Adaptive Alloimmunity

J. Ali, I. Harper, M. Negus, E. Bolton, K. Saeb-Parsy, J. Bradley, G. Pettigrew.

5:30pm-6:30pm: IgM+ Antigen Binding B Cells in Peripheral Blood Regulate IFNγ Production in Response to HLA Proteins

L. McLaughlin,¹ K. Shiu,¹ G. Lombardi,¹ J. Spencer,² R. Vaughan,¹ A. Dorling.¹

5:30pm-6:30pm: Impact of CXCR4/CXCL12 Blockade on Normal Plasma Cells In Vivo

N. Moore,¹ M. Moreno Gonzales,² M. Stegall.¹

5:30pm-6:30pm: Interactions Between Platelets and Liver Sinusoidal Endothelial Cells Initiate Liver Regeneration

J. Meyer,^1,2 E. Lejmi,² P. Fontana,^2,3 P. Morel,^1,2 C. Gonelle-Gispert,² L. Bühler.^1,2

5:30pm-6:30pm: MHC-Class-II Specific Sensitization in a Non-Human Primate Model of Sensitzation

C. Burghuber,^1,2 J. Kwun,¹ A. Gibby,¹ N. Iwakoshi,¹ S. Knechtle.¹

5:30pm-6:30pm: Microchimerism-Tolerance “Missing Link”: Exosome Acquisition by Host Dendritic Cells

W. Bracamonte-Baran, E. Jankowska-Gan, Y. Zhou, W. Burlingham.

5:30pm-6:30pm: Pancreas Transplant Sera Improves the Function and Proliferation of Endothelial Cells

J. Pollett, L. Margetich, N. Thai.

5:30pm-6:30pm: Presence of Donor Leukocytes and Donor MHC-Cross-Dressed Recipient Cells and Its Relationship to Direct T Cell Alloresponses After Allotransplantation

J. Marino,¹ P. Crosby Bertorini,¹ M. Uehara,² J. Paster,¹ S. Mordecai,³ W.-H. Liu,¹ L. Liu,¹ R. Abdi,² G. Tocco,¹ J. Kim,¹ J. Markmann,¹ G. Benichou.¹

5:30pm-6:30pm: Single Cell Phospho-Protein Analysis Demonstrates That Immunosuppressive Drugs Inhibit MAPK and mTOR Signaling Molecules in Primary Monocytes After Transplantation

N. Kannegieter, D. Hesselink, R. Kraaijeveld, G. de Graav, M. Betjes, W. Weimar, C. Baan.

5:30pm-6:30pm: T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques

C. Burghuber,^1,2 J. Kwun,¹ E. Page,¹ F. Leopardi,³ A. Gibby,¹ A. Farris,¹ N. Iwakoshi,¹ S. Knechtle.¹

5:30pm-6:30pm: The 20S Proteasome Is Active in Apoptotic Nanovesicles and Controls Anti-LG3 Antibody Production

M. Dieudé,^1,4 C. Bell,^2,4 J. Turgeon,^1,4 D. Beillevaire,^1,4 K. Hamelin,^1,4 S. Qi,^1,4 N. Pallet,^1,4 C. Rondeau,³ D. Gingras,³ M. Desjardins,³ P. Thibault,^2,4 M.-J. Hébert.^1,4

5:30pm-6:30pm: The Immunogenic Perlecan Fragment LG3 Is Released Through Apoptotic Extracellular Vesicles Downstream of Caspase-3 Activation

D. Beillevaire,¹ J. Turgeon,¹ D. Gingras,² é. Boilard,³ M. Dieudé,¹ M.-J. Hébert.¹

5:30pm-6:30pm: Tissue Engineering Human Kidneys for Costimulation Blockade

L. Brasile,¹ N. Henry,¹ A. Meyer,¹ B. Stubenitsky.²

5:30pm-6:30pm: Transplant Glomerulopathy in a Novel Model of Chronic Antibody Mediated Rejection Is Associated With DSA and Glomerular IgM

S. Panzer,¹ S. Reese,¹ N. Wilson Schlei,¹ W. Zhong,² A. Djamali.¹

5:30pm-6:30pm: mTOR Inhibitors Reduce the Endothelial Transmigration of Leukocytes After Ischemia

I. Werner, A. Hernandez-Sierra, F. Guo, A. Moritz, A. Beiras-Fernandez.

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