2017 American Transplant Congress » Poster Session B: Allorecognition and T Cell Biology

6:00pm-7:00pm

A New and Potent Distal Enhancer of the IL2 Gene.

R. Thomas,¹ P. Mehra,¹ M. Johnson,² S. Grant,² A. Wells.¹

6:00pm-7:00pm

Assessment of Cardiosphere-Derived Cell Exosomes as Possible Modulator of Alloimmunity in a Mouse Model of HLA-A2 Allosensitization.

I. Kim,¹ G. Wu,¹ N.-N. Chai,¹ G. De Couto,² E. Marban,² A. Klein,¹ S. Jordan.¹

6:00pm-7:00pm

CD4 T Cells and Co-Engagement with Foreign Protein Are Required in Antibody Response to Non-Self Blood Group A-Antigen.

I. Adam, B. Motyka, L. West.

6:00pm-7:00pm

Donor Leukocytes Are Eliminated by the Host's Immune System Shortly After Skin Transplantation in Mice.

J. Marino, B. Gonzalez-Nolasco, G. Benichou.

6:00pm-7:00pm

Ex-Vivo Mitomycin-C Exposure Reduced Immunogenicity and Prolonged Survival of Islets by Suppressing the Secretion of Multiple Chemotaxis Factors.

N. Sato,¹ T. Anazawa,² A. Kenjyo,¹ T. Kimura,¹ R. Okada,¹ T. Ishigame,¹ Y. Kofunato,¹ J. Watanabe,¹ M. Muto,¹ A. Nishimagi,¹ M. Gotoh,¹ S. Marubashi.¹

6:00pm-7:00pm

Fate and Function of CD8+ T Cells Primed by Fetal Antigen During Pregnancy.

P. Porrett,¹ R. Xu,¹ E. Wherry.²

6:00pm-7:00pm

HLA Class II Molecules Partner with TLR4 to Stimulate Endothelial Cell Activation and Proliferation.

Y.-P. Jin, E. Reed.

6:00pm-7:00pm

HLA-DPA1 and HLA-DPB1 Frequencies in the US Populations.

Z. Du, J. Patel, C. Braun, B. Norton.

6:00pm-7:00pm

Increased T Cell Exhaustion in Dialysis Patients.

M. Bastiaansen, A. Uffing, L. Riella.

6:00pm-7:00pm

Memory T Cells Are Decreased in Transplant Recipients Deficient in miR-182.

V. Kaul, L. Wei, X. Qu, O. Martinez, S. Krams.

6:00pm-7:00pm

Modification of Human Endothelial Cells by CRISPR/Cas9-Mediated Ablation of Class I and II Major Histocompatibility Complex Antigen Expression.

J. Merola, C. Anderson, H. Xu, T. Manes, J. Pober.

6:00pm-7:00pm

Non-Human Primate Auto-Immune Responses to Col V, Kα-1Tubulin and Vimentin Are P2X7R Dependent.

J. Sullivan,¹ E. Jankowska-Gan,¹ D. Kaufman,¹ L. Denlinger,² W. Burlingham.¹

6:00pm-7:00pm

Persistent Donor Antigen Leads to Dysfunctional CD4⁺ Memory T Cell Development.

M. Miller,¹ Y. Wang,¹ L. Chen,¹ Y. Lei,¹ M. Daniels,^2,3 E. Watkins,⁴ C. Mora Solano,² C. McIntosh,¹ N. Isaad,⁵ A. Chong,² M.-L. Alegre.¹

6:00pm-7:00pm

Phenotypic and Functional Assessment of T Cell Alloimmunity After Liver Transplantation.

T. Taner, M. Hansen, W. Park, M. Stegall.

6:00pm-7:00pm

Placental Leukocytes Are Maternally Derived: Implications for Pregnancy-Induced Alloimmunization.

P. Porrett,¹ E. Lewis,² R. Xu,¹ A. Brown,² E. Wherry,³ M. Elovitz.²

6:00pm-7:00pm

Quantity and Functions of CD4^–CD8^– Double Negative (DN) αβ T Cells in Kidney Is MHC Dependent.

M. Sadasivam, S. Noel, S. Lee, A. Hamad, H. Rabb.

6:00pm-7:00pm

SIRPα⁺ DCs and the Time-Dependent CD4⁺CD8⁺ Double Positive T Cell Infiltration in Accepted Renal Allografts.

T. Ashry,^1,2 C. Yang,² B. Jiang,² D. Ndishabandi,² P. Russel,^1,2 R. Colvin,^1,2 J. Madsen,^1,2 A. Alessandrini.^1,2

6:00pm-7:00pm

Suppression of T Cell Proliferation by CpG-Activated B Cells Depends on Granzyme-B and Cell-Cell Contact, but Not on IL-10.

L. Kojima,¹ S. Kimura,^1,2 K. Lee,¹ C. Schuetz,¹ L. Washburn,¹ K. Deng,¹ H. Tector,¹ B. Amundsen,^1,2 D. Ndishabandi,^1,2 A. Markmann,¹ M. Markmann-Porch,¹ T. Oura,¹ A. Alessandrini,^1,2 J. Kim,¹ H. Yeh,^1,2 J. Markmann.^1,2

6:00pm-7:00pm

T-Cell Aging Parameters in the Lymph Node and Peripheral Blood Are Strongly Associated but Terminally Differentiated T Cells Are Mainly Located within the Circulation.

B. Dedeoglu,¹ A. de Weerd,¹ L. Huang,¹ A. Langerak,² M. Klepper,¹ W. Verschoor,¹ D. Reijerkerk,¹ C. Baan,¹ N. Litjens,¹ M. Betjes.¹

6:00pm-7:00pm

The Inhibitory Effect of Plasma on T Cell Activation: Possible Role of Plasma Exchange in Anti Rejection Therapy.

A. Assounga,^1,2 S. Omarjee.¹

6:00pm-7:00pm

The Treg/Th17 Axis: A Dynamic Balance Regulated by Stromal Laminins.

T. Simon, J. Bromberg.

6:00pm-7:00pm

Tofacitinib-Loaded Solid Lipid Nanoparticles Inhibits Dendritic Cell Antigen Presenting Functions and Achieve Selective In Vivo Targeting.

G. Raimondi,¹ X. Calderon-Colon,² J. Budihardjo,¹ A. Mirdad,¹ M. Iglesias-Lozano,¹ J. Walch,¹ W. Lee,¹ G. Brandacher,¹ J. Patrone.²

6:00pm-7:00pm

Trafficking of Donor Leukocytes and Recipient Cells Cross-Dressed with Donor MHC Molecules After Transplantation of Cardiac Allografts in Monkeys.

J. Marino, K. Robinson, J. Paster, I. Hanekamp, J. Madsen, G. Benichou.

6:00pm-7:00pm

Two Promoter Polymorphisms in the Genes Encoding for Complement Regulating Proteins CD46 and CD59 in Kidney Donors Are Associated with Biopsy Proven Acute Rejection.

L. Michielsen,¹ A. van Zuilen,¹ T. Kardol-Hoefnagel,² M. Verhaar,¹ H. Otten.²

6:00pm-7:00pm

Vascularized Bone Marrow Mechanisms of Immunomodulation.

A. Khalifeh, E. Buckingham, M. Uluer, W. Hassanein, W. Twaddell, C. Drachenberg, A. Nam, S. Bartlett, R. Barth.

6:00pm-7:00pm

mTORC1 and 2 Regulate Dendritic Cell (DC) Metabolism and Allostimulatory Function of Donor DCs in Skin Transplantation.

A. Watson,^1,2 H. Dai,^1,3 A. Menk,^4,5 G. Delgoffe,^4,5 A. Thomson.^1,2,3