2016 American Transplant Congress » Poster Session B: Allograft Rejection, Tolerance, and Xenotransplantation

Date: Sunday, June 12, 2016

Time: 6:00pm-7:00pm

Location: Halls C&D

Session Type: Poster Session

Meeting: 2016 American Transplant Congress

6:00pm-7:00pm: A Novel Humanized Mouse Model Incorporating Non-Fetal Tissue.

M. Brown, I. Norman, Y. Zhou, W. Lou, J. Sullivan, W. Burlingham.

6:00pm-7:00pm: A Novel Inflammation-Targeting Tacrolimus Hydrogel for Liver Transplantation.

J. Jia,¹ J. Li,¹² Y. Zhou,¹ L. Jiang,¹ J. Zhang,¹ H. Lu,¹ H. Xie,¹ L. Zhou,¹ P. Kumur,³ S. Zheng.¹²

6:00pm-7:00pm: Activation of Alloreactive T Cells by Allogeneic Exosomes and Cells Cross-Dressed with Allogeneic MHC Molecules.

M. Babiker-Mohamed, J. Marino, P. Crosby, G. Benichou.

6:00pm-7:00pm: Aging Is Critically Impacting the Efficacy of Immunosuppressants.

J. Schuitenmaker, K. Edtinger, M. Seyda, H. Uehara, M. Quante, A. ElKhal, S. Tullius.

6:00pm-7:00pm: Anti-BTLA Antibody (6B2) Induced Prolongation of Fully MHC-Mismatched Murine Cardiac Allograft and Generation of Foxp3+ Regulatory T Cells.

M. Uchiyama,^1,2 E. Yin,^2,3 X. Jin,^2,4 T. Shimokawa,¹ H. Yagita,⁵ M. Niimi.²

6:00pm-7:00pm: Aryl Hydrocarbon Receptor Expression Increases in Skin Graft-infiltrating Th1 and Treg Cells.

J. Fechner, W. Julliard, L. Owens, J. Mezrich.

6:00pm-7:00pm: B Lymphocyte-Induced Maturation Protein-1 Promotes Allograft Survival via Modulation of T Cell Development.

A. Wang,¹ C. Loh,^1,3,4 S.-J. Chen,² C.-H. Lin,¹ H.-K. Sytwu,² S.-H. Chuang,¹ F.-C. Wei.^1,4

6:00pm-7:00pm: Belatacept Immunotherapy Is Not Augmented by Blockade of Activated LFA-1 in a Nonhuman Primate Renal Transplant Model.

K. Samy,¹ M. Mulvihill,¹ B. Collins,¹ D. Lo,² M. Song,¹ F. Leopardi,¹ A. Kirk.^1,2

6:00pm-7:00pm: Bile Acid Signaling Affects Metabolism and Prolongs Allograft Survival in Obese Recipients.

M. Quante, A. ElKhal, M. Seyda, J. Schuitenmaker, H. Uehara, S. Tullius.

6:00pm-7:00pm: CMV-Accelerated Cardiac Allograft Rejection Is Associated with Dysregulation of Sphingolipid Metabolomics.

J. Burg,¹ T. Andoh,² N. Haese,² C. Kreklywich,² K. Watters,³ T. Metz,³ S. Orloff,¹ D. Streblow.²

6:00pm-7:00pm: Direct Alloimmunity Is Driven by Recipient APCs Displaying Donor MHC Molecules.

J. Marino,¹ J. Paster,¹ P. Crosby,¹ M. Uehara,² S. Mordecai,¹ R. Abdi,² G. Tocco,¹ G. Benichou.¹

6:00pm-7:00pm: Distinct Effects of Chronic Hyperglycemia on Cellular and Humoral Alloresponses In Vivo.

N. Bishop,¹ K. Beard,² R. Gill.²

6:00pm-7:00pm: Donor Sharpin Expression Modulates TNFα Mediated Inflammation and Cardiac Allograft Rejection in Mice.

R. Ang,¹ P. Heeger,² A. Ting.¹

6:00pm-7:00pm: ESAT-6 Inhibits Donor-Specific Memory CD8+ T Cell Generation and Alloimmune Responses.

Z. Dai,¹ H. Dai.²

6:00pm-7:00pm: Eomesodermin Expression by CD8+ Alloreactive T Cells in Human and Nonhuman Primate Allograft Recipients.

A. Perez-Gutierrez, L. Lu, A. Zahorchak, Y. Ono, A. Thomson, M. Ezzelarab.

6:00pm-7:00pm: Evaluation of Conformational Diversity of a Single HLA-I Molecule Coated on Single Antigen Beads: Potential Impact on Organ Allocation?

V. Jucaud, M. Ravindranath, P. Terasaki.

6:00pm-7:00pm: Exosome-Like Vesicles Released in Association with Tissue Injury Trigger Anti-LG3 Production.

M. Dieudé,^1,2,3 J. Turgeon,^1,3 B. Yang,^1,2,3 L. Pomerleau,^1,3 K. Hamelin,^1,3 S. Lan,^1,2,3 S. Qi,^1,3 D. Gingras,^1,3 W. Dhari,¹ A. Rivard,¹ M.-J. Hébert.^1,2,3

6:00pm-7:00pm: Function of Sertoli Cells in Regulating Allogeneic T Cell Differentiation into Treg and Th17 In Vitro.

L. Xie,¹ W. Jiang.²

6:00pm-7:00pm: Heat Shock Protein 90 Inhibitor 17DMAG Is a Potential New Therapeutic Agent Against Acute Allograft Rejection.

T. Maehana,¹ T. Tanaka,¹ H. Kitamura,² N. Masumori.¹

6:00pm-7:00pm: Heterologous Persistent and Latent Viral Infections Do Not Impact Graft Survival.

J. Espinosa,^1,2 M. McRae,¹ J. Wang,¹ A. Kirk.¹

6:00pm-7:00pm: High Concentrations of CXCL9 and CXCL10 Chemokines but Not CXCL8 (IL-8), IL-6, TNF-a or IFN-g in Biopsy Tissue Are Associated with Pathological Staging of Rejection After Kidney Transplantation.

C. Falk,¹ C. Neudörfl,¹ K. Daemen,¹ J. Keil,¹ F. Lehner,² H. Haller,³ J. Schmitz,⁴ C. Blume,⁵ J.-H. Bräsen.⁴

6:00pm-7:00pm: Human PDL1⁺ SLA-DR^–Swine Vascular Endothelial Cells Suppress Pig-Human PBMC Xeno-MLR(Mixed Lymphocyte Reaction) by Inducing Human Regulatory IL-10⁺Tr1(Type 1 Regulatory T Cells) Subset for Suppression of Xenogeneic Reactions.

Q. Shao, Q. Diag.

6:00pm-7:00pm: Imaging Cell Biology In Vivo with Intravital-Microscopy.

T. Ueno,¹ M. Yeung,¹ N. Igarashi,³ T. Yokoyama,² Y. Kihara,² O. Konno,² Y. Nakamura,² H. Iwamoto,² T. Ikeda,³ M. McGrath,¹ M. Sayegh,¹ A. Chandraker.¹

6:00pm-7:00pm: Impact of Mixed Xenogeneic Chimerism on Human B Cell Response to Pig Antigens.

H. Li, S. Shao, P. Vishwasrao, M. Holzl, M. Sykes.

6:00pm-7:00pm: In Vitro Reactivity of CD4⁺ T Cells Subsets from Hosts with Antigen Specific Transplant Tolerance Mediated by CD4⁺CD25⁺T Cells.

B. Hall, C. Robinson, K. Plain, N. Verma, G. Tran, N. Carter, M. Nomura, R. Boyd, S. Hodgkinson.

6:00pm-7:00pm: Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allografts by Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2).

E. Yin,^1,2 M. Uchiyama,^1,3 X. Jin,^1,4 T. Shimokawa,³ H. Yagita,⁵ M. Niimi.¹

6:00pm-7:00pm: Limiting Helper Functions of CD4 T Cells Improves Efficacy of Induction Therapy without Compromising Responses to Third Party Antigens.

K. Ayasoufi, V. Gorbacheva, F. Ran, A. Valujskikh.

6:00pm-7:00pm: Long Term Heterotopic Cardiac Xenograft Survival from Donor Pigs with Six Gene Modifications.

M. Mohiuddin,¹ A. Singh,¹ J. Chan,¹ P. Corcoran,¹ M. Thomas III,² B. Lewis,² D. Ayares,³ K. Horvath.¹

6:00pm-7:00pm: Long-Term Islet Xenograft Survival Requires Effective Control of Early Xenogeneic IL-17 Response and Late Xenogeneic IFN-γ Response.

H. Kang,¹ S. Wang,² X. Zhang,³ A. Singh,⁵ L. Zhang,¹ W. Suarez-Pinzon,⁵ S. Miller,⁴ B. Hering,⁵ X. Luo.^1,3,4

6:00pm-7:00pm: Lysosome Ativity Regulates LG3 Export by Apoptotic Cells.

D. Beillevaire,^1,2,4 J. Turgeon,^1,2,4 E. Boilard,^3,4 M. Dieudé,^1,2,4 M.-J. Hébert.^1,2,4

6:00pm-7:00pm: MHC/HLA-Specific IgE in Allotransplantation.

A. Farkas,¹ U. Baranyi,¹ L. Unger,¹ B. Mahr,¹ K. Hock,¹ N. Pilat,¹ H. Regele,² M. Wahrmann,³ G. Böhmig,³ R. Valenta,⁴ T. Wekerle.¹

6:00pm-7:00pm: MicroRNA let-7i Regulates Dendritic Cells Maturation Targeting Interleukin-10 via JAK1-STAT3 Signal Pathway Subsequently Induces Prolonged Cardiac Allograft Survival in Rats.

X. Jin,¹ Y. Sun,² X. Liu,² J. Wang,¹ S. Xu,¹ L. Yao,¹ Z. Zhao,³ L. Jiang,⁴ Q. Wu,⁵ J. Wu.²

6:00pm-7:00pm: Multiplex Profiling of Plasma Proteins After Xenogenic Lung Exposure.

A. Azimzadeh,¹ N. Cheng,¹ X. Cheng,¹ E. Schwartz,¹ L. Burdorf,¹ S. Dahi,¹ N. Kubicki,¹ D. Parsell,¹ T. Zhang,¹ D. Cooper,² C. Phelps,³ D. Ayares,³ R. Pierson III.¹

6:00pm-7:00pm: Neonatal Tolerance to Blood Group A-Antigen in a Mouse Model of ABO-Incompatible Heart Transplantation (ABOi HTx).

B. Motyka,¹ B. Lamarche,¹ K. Labonte,¹ S. Wang,¹ J. Pearcey,¹ K. Tao,¹ M. Mengel,¹ B. Sis,¹ P. Cowan,² L. West.¹

6:00pm-7:00pm: Porcine Islets Engineered with SA-FasL Protein Induces Robust Tolerance in Mice through CD4⁺CD25⁺FoxP3⁺ Treg Cells.

K. Woodward,¹ H. Zhao,¹ H. Shirwan,¹ F. Wang,¹ M. Graham,² B. Hering,² E. Yolcu.¹

6:00pm-7:00pm: Profiling of T Cell Subsets in a Primate Cardiac Transplant Model.

N. O'Neill, T. Zhang, G. Braileanu, W. Sun, X. Cheng, C. Evans, R. Pierson, A. Azimzadeh.

6:00pm-7:00pm: Rapamycin Prolongs Cardiac Allograft Survival in a Mouse Model by Inducing Myeloid-Derived Suppressor Cells.

T. Nakamura, K. Masuda, T. Matsuyama, H. Ushigome, N. Yoshimura.

6:00pm-7:00pm: Recapitulating Peripheral T Cell Development in Neonatal Mice to Induce Transplant Tolerance.

R. Bascom, K. Tao, L. West.

6:00pm-7:00pm: Sepsis Prolongs Allograft Survival Compared with Non-Septic Infection in a Murine Model of Skin Transplantation and Pseudomonas aeruginosa Pneumonia.

L. Margoles, S. Laurie, C. Coopersmith, M. Ford.

6:00pm-7:00pm: Successful Human-to-NonHuman Primate Pancreatic Islet Intraportal Xenotransplantation Using a Human Allo-Based Immunosuppression Regimen and Its Potential Pre-Clinical Application.

J. McGarrigle,¹ M. Bochenek,¹ E. Marchese,¹ A. Khan,¹ D. Gutierrez,^1,2 A. Mikalauskaite,¹ B. McCracken,¹ M. Reedy,¹ M. Omami,¹ C.-C. Yeh,¹ M. Spaggiari,¹ M. Nourmohammadzadeh,^1,2 D. Isa,¹ S. Ghani,¹ L.-J. Wang,¹ J. Mendoza-Elias,^1,2 Y. Wang,¹ J. Oberholzer.^1,2

6:00pm-7:00pm: Th17 Development Is Critical for Airway Epithelial Injury After Transplantation.

J. Xu, Y. Zhang, L. Wang, X. Li, R. Chen, R. Zhang, Y. Ding.

6:00pm-7:00pm: The Impact of a Novel Dual Adenosine Triphosphate-Competitive mTOR Inhibitor (TORKinib) on Alloimmunity and Transplant Survival.

D. Fantus,¹ Y. Ono,¹ S. Yokota,¹ C. Komatsu,¹ H. Turnquist,^1,2 A. Thomson.^1,2

6:00pm-7:00pm: The Increase of Serum MiR-142-3p Level in Acute Cardiac Rejection as a Reflection of Exosome-Mediated Genetic Exchange Between T Cells and Endothelial Cells.

I. Dewi,¹ Z. Hollander,² B. McManus,² O. Gidlöf,¹ J. Öhman.¹

6:00pm-7:00pm: Treg-Rich Organized Lymphoid Structures (TOLS) in Spontaneously Accepted Mouse Kidney Allografts.

C. Yang,¹ E. Farkash,² D. Ndishabandi,¹ R. White,¹ B. Jiang,¹ I. Aljabban,¹ P. Russell,¹ J. Madsen,¹ R. Colvin,¹ A. Alessandrini.¹

6:00pm-7:00pm: Vascular Endothelial Cell Activation by Mitochondria Links Innate and Adaptive Immune Responses to Allograft Injury.

F. Feng, H. Xu, L. Lin, A. Kirk, T. Brennan.

6:00pm-7:00pm: iNKT Cell Activation Under Co-Stimulatory Blockade Establishes Mixed Chimerism Through Thymic Regulatory T Cell Activation.

T. Hirai,¹ Y. Ishii,² R. Ishii,¹ S. Miyairi,¹ M. Ikemiyagi,¹ M. Okumi,¹ K. Tanabe.¹

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