2022 American Transplant Congress » Ischemia Reperfusion

3:30pm-3:40pm

Final Report of the Use of α-Lipoic Acid in Liver Transplantation to Prevent Ischemia Reperfusion Injury

P. C. Casciato¹, N. Ambrosi², F. Caro², L. Oliveira¹, F. Zalazar¹, A. Garmendia¹, M. Bonifacio¹, M. Padilla¹, J. Paladini¹, J. Di Menno¹, J. Pekjol¹, E. de Santibañes¹, M. de Santibañes¹, G. Adrian¹, C. Incardona¹, E. Chuluyan²

3:40pm-3:50pm

Pretransplant Rifaximin Treatment Improves Liver Transplant Outcomes in Mice and Humans

H. Kojima, S. Kageyama, T. Ito, D. Noguchi, H. Hirao, K. Kadono, K. J. Dery, F. Kaldas, J. Kupiec-Weglinski

3:50pm-4:00pm

CEACAM1 Splice Isoforms Are Regulated by Hypoxia Inducible Factors 1 alpha (HIF-1a) to Protect Against Ischemic Injury in Mouse and Human Liver Transplantation

K. J. Dery¹, H. Kojima¹, K. Kadono², H. Hirao¹, J. Kupiec-Weglinski³

4:00pm-4:10pm

Abnormal Kidney T Cell Metabolism During Ischemia Reperfusion Injury Can Be Modified to Improve Organ Structure and Function

K. Lee, E. A. Thompson, C. H. Patel, S. Gharaie, J. T. Kurzhagen, S. Noel, P. M. Pierorazio, B. S. Slusher, H. Rabb

4:10pm-4:20pm

Novel Immune Checkpoint Molecule TIGIT Mediates Experimental Kidney Ischemia Reperfusion Injury

S. Noel, K. Lee, S. Gharaie, J. T. Kurzhagen, H. Rabb

4:20pm-4:30pm

Ikaros-SIRT1 Signaling Axis Regulates Macrophage Pyroptosis and Ischemia-Reperfusion Injury (IRI) in Mouse and Human Liver Transplantation

K. Kadono¹, H. Hirao¹, H. Kojima¹, K. J. Dery¹, X. Li², J. Kupiec-Weglinski¹

4:30pm-4:40pm

Evolution of Donor-Derived Cell-Free DNA During the First Week After Surgery Predicts Renal Function Recovery After Kidney Transplantation

D. Cucchiari¹, E. Cuadrado¹, E. Gonzalez¹, J. Puig¹, M. Ramirez-Bajo¹, P. Ventura-Aguiar¹, I. Revuelta², B. Bayès¹, F. Diekmann¹

4:40pm-4:50pm

Disulfide HMGB1 Reprograms Macrophages to Induce Alloimmunity via TLR4 and TLR9 Pathways Following Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation

A. Q. Terry¹, R. A. Sosa¹, F. Kaldas², R. Busuttil³, D. Gjertson¹, J. Kupiec-Weglinski¹, E. Reed¹

4:50pm-5:00pm

Combined Genome Wide and Single Nuclei Transcriptomics in Posttransplant Acute Kidney Injury Identifies Early Proinflammatory/Profibrogenic Cell Origin

J. McDaniels¹, T. Rousselle¹, E. Bardhi¹, A. Shetty¹, E. Akalin², D. Maluf¹, V. Mas¹