2020 American Transplant Congress » Immunosuppression Preclinical Studies

3:15pm-3:27pm

Notch Signaling Inhibition via Blockade of Delta-Like Ligand 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection

A. J. Matar, B. P. Lovasik, Y. Dong, D. A. Faber, J. Habib, C. A. Breeden, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams

3:27pm-3:39pm

Suppressing Laminin Alpha5 Creates Tolerogenic Niches for Allograft Survival

L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, C. Paluskievicz¹, J. Zhao², R. Abdi², J. S. Bromberg¹

3:39pm-3:51pm

Donor-Derived DCREG Infusion Prolongs Kidney Allograft Survival in Rhesus Monkeys Treated with Co-Stimulation Blockade and Calcineurin Inhibition

Y. Wang, S. Kazuki, L. Lu, A. Zahorchak, H. Dai, A. Ganoza, M. Wijkstrom, A. Humar, M. Ezzelarab, A. Thomson

3:51pm-4:03pm

Early Post-Transplant Infusion of Ex Vivo-Expanded Autologous Polyclonal Regulatory T Cells (Treg) Prolongs Kidney Allograft Survival in Non-Lymphodepleted, CTLA4Ig-Treated Rhesus Monkeys

K. Sasaki, Y. Wang, R. Nakano, L. Lu, J. Hughes, V. Vujevich, A. J. Ganoza, M. Wijkstrom, A. Humar, A. W. Thomson, M. B. Ezzelarab

4:03pm-4:15pm

Selective Dual Co-Stimulatory Blockade of CD28/CD80-86 and PD1-PL2 with a Novel Recombinant Bi-Specific Fusion Protein (Hybri-2) Promotes Successful Humoral Desensitization in a Stringent Sensitized Rat Model

A. Torija, E. Crespo, M. Jarque, N. Bolaños, M. Meneghini, A. Favà, J. Torras, J. Grinyo, O. Bestard

4:15pm-4:27pm

Immunomodulation with FasL Presenting Biomaterials Achieves Long-Term Survival of Allogeneic Islets in the Absence of Chronic Immunosuppression in a Non-Human Primate Model

J. Lei¹, H. Deng¹, T. Chen¹, K. Lee¹, C. Peters¹, Z. Yang¹, K. Deng¹, G. Rickert¹, I. Rosales¹, N. Serifis¹, M. Coronel², M. Hunckler², E. Yolcu³, H. Shirwan³, A. García², J. Markmann¹

4:27pm-4:39pm

Costimulation Blockade-Based Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model

R. Schmitz, Z. W. Fitch, P. M. Schroder, A. Y. Choi, M. Manook, J. Yoon, J. Kwun, S. J. Knechtle