2015 American Transplant Congress » Concurrent Session: Alloantibodies and Rejection: Animal Models

Date: Sunday, May 3, 2015

Time: 4:00pm-5:30pm

Location: Room 118-AB

Session Type: Concurrent Session

Meeting: 2015 American Transplant Congress

4:00pm-4:12pm: Antibody-Mediated Rejection of Renal Allografts by CCR5-/- Mice Does Not Require CD8 T Cells

N. Kohei,¹ T. Tanaka,¹ H. Tsuda,¹ N. Dvorina,¹ K. Tanabe,² W. Baldwin,¹ R. Fairchild.¹

4:12pm-4:24pm: Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation

C. Burghuber,^1,2 J. Kwun,¹ E. Page,¹ A. Gibby,¹ F. Leopardi,³ A. Farris,¹ N. Iwakoshi,¹ S. Knechtle.^1,3

4:24pm-4:36pm: CN Inhibition (But Not mTOR Inhibition) of a Novel CD8⁺ T Cell Regulatory Mechanism Results in Higher Alloantibody Posttransplant

J. Zimmerer, S. Elzein, C. Wright, G. Bumgardner.

4:36pm-4:48pm: Toll-Like Receptor 4-Signaling Abrogates Inhibitory Effect of Calcineurin Inhibitor on B-Cells Responding to Blood Group A-Antigens

H. Sakai, Y. Tanaka, H. Ohdan.

4:48pm-5:00pm: Multicenter Validation of a Molecular Diagnostic for Antibody-Mediated Rejection in Formalin-Fixed Paraffin-Embedded Human Renal Allograft Biopsies

B. Adam,¹ B. Afzali,¹ N. Shah,¹ K. Dominy,² R. Gill,¹ L. Hidalgo,¹ P. Campbell,¹ C. Roufosse,² M. Mengel,¹ B. Sis.¹

5:00pm-5:12pm: Marked Suppression of Posttransplant Alloantibody Production and Primed B cell Function In Vivo by mTOR Inhibition Compared to Calcineurin Inhibition

C. Wright, J. Zimmerer, T. Pham, G. Bumgardner.

5:12pm-5:24pm: Passive Administration of Antibodies to Cardiac Myosin Immediately Following Syngenic Cardiac Transplantation Result in Rejection

M. Sharma, M. Gunasekaran, N. Benshoff, W. Liu, A. Gelman, T. Mohanakumar.

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