2015 American Transplant Congress
Pediatric Liver Transplantation for Metabolic Diseases: Analysis of Children's Hospital of Pittsburgh (CHP) and United Network for Organ Sharing (UNOS) Databases
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Purpose: To analyze long term patient survival outcomes after primary LTx for metabolic disease in children <21 years at CHP (1981-2014) and the multi-center UNOS…2015 American Transplant Congress
A Single Center Study of the Implementation Costs of the New Kidney Allocation System
Transplantation, University of Maryland Medical Center, Baltimore, MD.
Background: Changes to the Kidney Allocation System (KAS) required transplant programs to utilize resources to prepare for its implementation. A complex strategy was developed which…2015 American Transplant Congress
Passive Administration of Antibodies to Cardiac Myosin Immediately Following Syngenic Cardiac Transplantation Result in Rejection
Surgery, Washington Univ Sch of Med, St. Louis, MO.
Introduction: Auto-immune responses to cardiac myosin, a heart specific protein has been proposed to be a target auto-antigen resulting in cardiac allograft vasculopathy following transplantation.…2015 American Transplant Congress
Renal Tubular Dysfunction Following Donor Nephrectomy and Its Impact On Residual Kidney Function
Background: Recent publications have described an increasing incidence of end stage renal disease amongst kidney donors. This highlights the paucity of knowledge which exists in…2015 American Transplant Congress
Engagement of the Vasopressin Receptor On Hepatocytes Protects Liver from Ischemia-Reperfusion Injury Via the WNT-β-Catenin-SGK1-FOXO Pathway
The synthetic vasopressin analogue, terlipressin, has been extensively used in the management of certain complications associated with end-stage liver diseases (ESLDs), however concerns have been…2015 American Transplant Congress
Long-Term Efficacy and Safety of an EVR- Vs. an MMF-Based Regimen After Pediatric Kidney Transplantation (KTX): A Case-Control Study Within the CERTAIN Registry
Background: Only short-term trials using everolimus (EVR) in children after KTX have been published. Hereby we present 4 year data on low-dose ciclosporin A (CsA),…2015 American Transplant Congress
VLA-4 Blockade Inhibits Endogenous Memory CD8 T Cell-Mediated Rejection of Cardiac Allografts
Endogenous memory CD8 T cells infiltrate cardiac allografts within 24 hours of reperfusion and are activated to proliferate and produce IFN-γ in response to donor…2015 American Transplant Congress
Clinical Relevance of C3d-Binding Donor-Specific Antibodies in Late Kidney Allograft Failure
Background: The objective of this study was to investigate the prognostic value of C3d-binding donor-specific antibodies (DSA) in determining late kidney allograft failure.Methods: 1048 patients…2015 American Transplant Congress
Serum Proteins Are Significantly Upregulated in Patients With Clinical Antibody-Mediated Rejection
Background: Antibody-mediated rejection (ABMR) is a major pathway associated with late graft loss. Although serum de novo donor-specific HLA antibodies are frequently observed in ABMR,…2015 American Transplant Congress
Long-Term Analysis of a Placebo-Controlled Trial of C1-INH for Prevention of Antibody-Mediated Rejection
Kidney Transplant, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Desensitization (DES) strategies focus primarily on antibody reduction using IVIG, rituximab ± PLEX to prevent DSA-induced antibody-mediated rejection (ABMR) and rebound B-cell activity. Recently,…
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