Am J Transplant, Volume 5, Suppl 3 Archives - Page 97 of 170 - ATC Abstracts

2015 American Transplant Congress
Microvascular Inflammation in Early Protocol Biopsies of Renal Allografts in Cases of Chronic Active Antibody-Mediated Rejection
T. Tsuji,¹ M. Yanai,¹ H. Itami,¹ Y. Ishii,¹ M. Akimoto,¹ N. Fukuzawa,² H. Harada,² Y. Fukasawa.¹
¹Demartment of Pathology, Sapporo City General Hospital, Sapporo, Japan; ²Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan.
Aim:Chronic active antibody-mediated rejection (chronic ABMR) is one important cause of late-stage renal allograft loss. However, few reports have used protocol biopsy to observe changes…
2015 American Transplant Congress
Determinants and Sequelae of Hepatic Artery Thrombosis After Liver Transplantation: A Registry Study of Recipient Diagnosis and Coagulopathy
J. Garonzik Wang,¹ M. Doyle,¹ K. Collins,¹ J. Lowell,¹ Y. Lin,¹ S. Shenoy,¹ J. Wellen,¹ W. Chapman,¹ D. Segev.²
¹Washington University, Barnes Jewish Hospital, Saint Louis, MO; ²Johns Hopkins University, Johns Hopkins Hospital, Baltimore, MD.
Hepatic artery thrombosis (HAT) is a dreaded complication following liver transplantation. Despite improvements in technique and procurement, HAT still occurs in approximately 2-5% of recipients.…
2015 American Transplant Congress
Results of Broader Sharing of Young Pediatric Donor Lungs and Priority Allocation System for Young Pediatric Lung Candidates
W. Cherikh,¹ A. Wilk,¹ L. Edwards,¹ G. Visner,² Y. Cheng,¹ S. Sweet.³
¹United Network for Organ Sharing, Richmond, VA; ²Boston Children's Hospital, Boston, MA; ³Washington Univ, St. Louis, MO.
Background. Two major changes for allocation of young pediatric (ped) lung (LU) donors and young ped candidates were implemented on 9/12/10. LUs from 0-11 year…
2015 American Transplant Congress
Iron Deficiency Impairs Regulatory T Cell Induction
R. Danger,¹ E. Bonaccorsi-Riani,¹ E. Kodela,¹ H. Collins,² R. Hider,³ M. Martínez-Llordella,¹ A. Sánchez-Fueyo.¹
¹Department of Liver Sciences, Faculty of Life Sciences & Medicine, MRC Transplant Centre, King's College London, London, United Kingdom; ²Department of Immunology, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom; ³Institute of Pharmaceutical Science, King's College London, London, United Kingdom.
In a recent clinical trial of immunosuppression withdrawal in adult liver transplant recipients, operational tolerance was associated with development of a transient lymphocyte infiltration rich…
2015 American Transplant Congress
Induction With ATG Is Not Associated With Increased Infections After Kidney Transplant Among HIV Positive Patients: Results of a National Study
L. Kucirka,¹ C. Durand,¹ S. Bae,¹ J. Locke,² D. Segev.¹
¹JHU, Baltimore; ²UAB, Birmingham.
Anti-thymocyte globulin (ATG) is widely used for induction, particularly for those at high risk for rejection. HIV+ kidney transplant (KT) recipients have 3 fold higher…
2015 American Transplant Congress
The Use of Eculizumab to Treat the Highly Sensitized Patient Awaiting Heart Transplant
J. Patel, D. Dilibero, M. Kittleson, S. Sana, F. Liou, D. Chang, A. Hage, L. Czer, A. Trento, N. Reinsmoen, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles, CA.
Purpose: Highly sensitized patients (pts) awaiting heart transplantation remain a significant challenge due to prolonged often prohibitive wait times for suitable organs and increased rejection…
2015 American Transplant Congress
Kidney Double Negative TCR αβ + Cells: Newly Described Intra-Renal Kidney Lymphocytes That Respond to Ischemia Reperfusion in Mice
M. Martina,¹ S. Bandapalle,² S. Noel,² A. Saxena,¹ A. Hamad,¹ H. Rabb.²
¹Pathology, Johns Hopkins University, Baltimore, MD; ²Medicine, Johns Hopkins University, Baltimore, MD.
Background TCRαβ+CD4-CD8- double negative (DN) T cells with immunoregulatory function are a significant component of T cells residing in the kidney. The exact role of…
2015 American Transplant Congress
Metrics of Global Health Status Signal Early Hospital Readmission Risk After Kidney Transplantation
M. Harhay,¹ A. Hill,² W. Wang,² O. Even-Shoshan,² A. Mussell,¹ J. Karlawish,³ R. Bloom,¹ H. Feldman,¹ J. Silber,² P. Reese.¹
¹Medicine, Division of Nephrology, University of Pennsylvania, Philadelphia, PA; ²Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; ³Medicine, Division of Geriatrics, University of Pennsylvania, Philadelphia, PA.
Background: Early (≤30 days) hospital readmission (EHR) after kidney transplantation (KT) is common, with diverse causes that likely include poor pre-KT health status. Transplant providers…
2015 American Transplant Congress
Hydrogen Sulfide Restores Protective Capacity of University of Wisconsin Solution During Normothermic Preservation
J. Grewal,¹ I. Lobb,¹ M. Whiteman,³ A. Sener.^1,2
¹Microbiology & Immunology, University of Western Ontario, London, ON, Canada; ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ³Experimental Therapeutics, University of Exeter Medical School, Exeter, England, United Kingdom.
Organ preservation solution is crucial in mitigating effects of ischemia reperfusion injury (IRI) associated with transplantation. Although University of Wisconsin (UW) solution is ideally suited…
2015 American Transplant Congress
A Common Gene Signature Across Multiple Studies Identifies Biomarkers and Functional Regulation in Tolerance to Renal Allograft
D. Baron,^1,2,3 G. Ramstein,⁴ M. Chesneau,^1,2,3 Y. Echasseriau,^1,2,3 A. Pallier,^1,2,3 C. Paul,^1,2,3 N. Degauque,^1,2,3 M. Hernandez-Fuentes,⁵ A. Sanchez-Fueyo,⁶ K. Newell,⁷ M. Giral,^1,2,3 J.-P. Soulillou,^1,2,3 R. Houlgatte,^8,9 S. Brouard.^1,2,3
¹UMR 1064 - CRTI, INSERM, Nantes, Loire Atlantique (44), France; ²ITUN, CHU de Nantes, Nantes, Loire Atlantique (44), France; ³Faculté de Médecine, Université de Nantes, Nantes, Loire Atlantique (44), France; ⁴UMR 6241 - LINA, Université de Nantes, Nantes, Loire Atlantique (44), France; ⁵MRC Centre for Transplantation, King's College London, London, United Kingdom; ⁶Institute of Liver Studies, King's College Hospital, London, United Kingdom; ⁷Department of Surgery, Emory University, Atlanta, GA; ⁸U954 - LNGERE, INSERM, Nancy, France; ⁹DRCI, CHU de Nancy, Nancy, France.
Patients tolerant to a kidney graft display a specific blood transcriptional pattern but reported results from five distinct studies hardly overlapped, raising the question of…