Am J Transplant, Volume 5, Suppl 3 Archives - Page 97 of 170 - ATC Abstracts

2015 American Transplant Congress
Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allografts by Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2)
E. Yin,^1,2 M. Uchiyama,^1,3,4 X. Jin,^1,5 T. Shimokawa,³ H. Yagita,⁴ M. Niimi.¹
¹Department of Surgery, Teikyo University, Tokyo, Japan; ²Department of Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; ³Department of Cardiovascular Surgery, Teikyo University, Tokyo, Japan; ⁴Department of Immunology, Juntendo University Hospital, Tokyo, Japan; ⁵Department of Cardiovascular and Thoracic Surgery, The 4th Affiliated Hospital of Harbin Medical University, Harbin, China.
Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA) and Programmed death (PD)-1 had been suggested to have immunomodulatory activity. This study investigated the…
2015 American Transplant Congress
Inhibition of T Cell Metabolism Reveals a New Approach to Preventing Graft Rejection
C.-F. Lee,^1,2 Y.-C. Lo,² G. Furtmüller,³ B. Oh,³ V. Andrade-Oliveira,² A. Thomas,⁴ G. Brandacher,³ J. Powell.²
¹Department of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital-Linkou Branch, Taoyuan, Taiwan; ²Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD; ³Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ⁴Brain Science Institute, Neurotranslational Program Johns Hopkins University School of Medicine, Baltimore, ND.
Upon antigen recognition and co-stimulation, T cells up-regulate the metabolic machinery necessary to proliferate and sustain effector function. Hallmarks of this response include a switch…
2015 American Transplant Congress
Low Vitamin D Exposure Is Associated With Higher Risk of Infection in Renal Transplant Recipients
L. Sacha,¹ H. Kalluri,² A. Ingemi,³ H. Johnson,⁴ D. Landsittel,⁵ M. Shullo,⁴ R. Venkataramanan.^2,6
¹Department of Pharmacy, Saint Barnabas Medical Center, Livingston, NJ; ²Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA; ³Department of Pharmacy, Sentara Norfolk General Hospital, Norfolk, VA; ⁴Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, PA; ⁵Department of Medicine, University of Pittsburgh, Pittsburgh, PA; ⁶Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA.
PURPOSE: Vitamin D has multiple vital functions within the immune system. This study aims to assess the relationship between vitamin D exposure and the incidence…
2015 American Transplant Congress
Divergence in Risk Factors for Graft Loss and Death Across Race May Mediate Kidney Transplant Outcome Disparity
M. Posadas Salas,¹ D. Taber,² M. Kamel,¹ M. Kadian,¹ M. Salazar,¹ P. Mohan,¹ T. Srinivas.¹
¹Department of Medicine, Medical University of South Carolina, Charleston, SC; ²Department of Surgery, Medical University of South Carolina, Charleston, SC.
Differences in outcomes between African American and non-African American kidney transplant recipients may reflect disparate access to health care. Minimizing this disparity demands a deeper…
2015 American Transplant Congress
Effect of Distinct Immunosuppressive Protocols On the Profile of Cytokines Expression in Renal Transplant Recipients of Extended Criteria Donor Kidneys
C. Montoro Mazeti,¹ C. Zangrossi Dezotti,¹ I. Fernandes-Charpiot,^1,2 H. Caldas,¹ M. Baptista,^1,2 M. Abbud Filho.^1,2,3
¹Laboratory of Immunology and Experimental Transplantation, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, SP, Brazil; ²Department of Medicine, Division of Nephrology, Sao Jose do Rio Preto Medical School, Sao Jose do Rio Preto, SP, Brazil; ³Urology and Nephrology Institute, Urology and Nephrology Institute, Sao Jose do Rio Preto, SP, Brazil.
Background: Transplant recipients (RTx) of kidneys classified as extended criteria (ECD) seems to have worst outcomes when compared with RTx of standard kidneys (SCD) and…
2015 American Transplant Congress
Hepatic Stellate Cells Inhibit T Cells Through Active TGFβ1 from a Cell-Surface-Bound Latent TGFβ1/GARP Complex
Y. Li, B.-G. Kim, S. Qian, J. Letterio, J. Fung, L. Lu, F. Lin.
Immunology, Lerner Research Institute, Cleveland Clinic; 2Pediatric Hematology-Oncology, Case Western Reserve University; 3General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Nonparenchymal cells appear to be critical to maintain the immunoprivileged status of liver as whole liver allografts are well-tolerated in mice, but allo-hepatocytes are rapidly…
2015 American Transplant Congress
Phenotype of Renal Tubular Cell Death During Delayed Graft Function
S. Jain,¹ R. Plenter,¹ T. Nydam,¹ C. Ruller,¹ C. Edelstein,^1,2 A. Jani.^1,2
¹University of Colorado, Aurora, CO; ²Veterans Affairs Medical Center, Denver, CO.
Background: Delayed graft function (DGF) independently predicts reduced 5 yr kidney transplant survival. Treatments of DGF are lacking. Cold ischemia (CI) is a significant risk…
2015 American Transplant Congress
Calcineurin-Inhibitor Conversion to mTOR Inhibitor in Renal Transplant Recipients Leads to Worse Long Term Clinical Outcomes
A. Alvarado,¹ A. Shetty,¹ O. Traitanon,¹ J. Leventhal,¹ V. Mas,² D. Chhabra,³ J. Matthews,¹ L. Gallon.¹
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²University of Virgina, Charlottesville, Va; ³Advocate Christ Medical Center, Chicago, IL.
We previously reported the short-term feasibility of Calcineurin-Inhibitor (CNI) elimination in kidney transplant recipients. We now report the long-term clinical impact on renal allograft function…
2015 American Transplant Congress
NFAT Regulated Cytokine Gene Expression for Immune Monitoring in Kidney Transplant Recipients
V. Tatapudi, A. Webber, C. Leung, F. Vincenti.
Div. of Nephrology, Dept. of Medicine, University of California, San Francisco Medical Center, San Francisco, CA.
Purpose of Study:To demonstrate that profiling kidney transplant recipients (KTR) on Tacrolimus (Tac) based immunosuppression based on quantitative analysis of NFAT (nuclear factor of activated…
2015 American Transplant Congress
12-Month Athena Study: Everolimus Vs. Standard Regimen in De Novo Renal Transplant Recipients
C. Sommerer,¹ B. Suwelack,¹ D. Dragun,¹ I. Hauser,¹ P. Schenker,¹ D. Bäumer,² B. Nashan,¹ F. Thaiss.¹
¹Athena Study Group, Germany; ²Novartis, Pharma, Germany.
Background: Post-kidney transplant (KTx) long-term and full dose/standard calcineurin inhibitor (CNI) use is associated with an increased risk for malignancies, cardiovascular disease, and renal failure.…