ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Non-Inferior Outcomes of Third and Fourth Renal Transplant. An Analysis of Our Experience

    H. Sharma, P. Yiannollou, O. Masood, G. Giffruda, R. Dhanda, D. Van Dellen, T. Campbell, R. Pararajasingam, T. Augustine, A. Tavakoli, B. Forgacs.

    Transplant Surgery, Manchester Royal Infirmary, Manchester, United Kingdom.

    INTRODUCTIONOutcome of third and subsequent renal transplants have not been associated with favorable outcomes. We analyze our experience in patients with three or more kidney-transplants…
  • 2015 American Transplant Congress

    Renal Dysfunction After Liver Transplantation in Recipients With Pre-Transplant Normal Renal Function

    S. Lee,2 J. Lee,1 M. Kim,1 B. Kim,3 D. Joo,1 G. Choi,1 J. Choi,1 S. Kim.1

    1Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea; 2Surgery, Ajou University School of Medicine, Suwon, Republic of Korea; 3Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

    Background. Renal dysfunction is a severe complication associated with adverse outcomes after liver transplantation (LT). The aim of our study is to identify the incidence…
  • 2015 American Transplant Congress

    Patients With Spontaneous Bacterial Peritonitis (SBP) Experience Survival Benefit After Live Donor Liver Transplantation (LDLT)

    M. Simpson, A. Qamar, F. Gordon, J. Pomposelli, M. Akoad, R. Jenkins, W. Lewis, A. Tien, E. Pomfret.

    Transplantation and Hepatobiliary Diseases, Lahey Hospital and Medical Center, Burlington, MA.

    Background: SBP is a life threatening complication of end stage liver disease. Reports indicate a 40-50% one year mortality rate in patients who experience SBP…
  • 2015 American Transplant Congress

    Husband to Wife Renal Transplants Are Associated With a Higher Risk of Early Antibody Mediated Rejection and Transplant Glomerulopathy

    H. Sawhney, M. Willicombe, P. Brookes, E. Santos, D. Taube.

    Renal and Transplant Centre, Hammersmith Hospital, Imperial Healthcare NHS Trust, London, England, United Kingdom.

    Patients with a low level preformed donor specific antibodies [DSA] with a negative FCXM/CDC cross match are at high risk of antibody mediated rejection [AMR]…
  • 2015 American Transplant Congress

    Laparoscopic Donor Nephrectomy of Multiple Renal Artery Kidneys: Single Center Experience

    A. AlShahrani, M. AlBuagmi, I. AlOraifi, M. Tawfeeq.

    Multi-Organ Transplant Center, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

    Introduction:Laparoscopic donor nephrectomy (LDN) is the preferred procedure to procure kidneys from most living donors (LDs). However, transplant surgeons might shy away from LDN when…
  • 2015 American Transplant Congress

    Lung Biopsy Findings in Pediatric Lung Transplant Patients With Restrictive Physiology

    J. Blatter,1 F. White,2 A. Faro,1 P. Michelson,1 U. Boston,3 P. Eghtesady,3 S. Sweet.1

    1Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO; 2Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO; 3Department of Cardiothoracic Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO.

    Background: Long-term survival in pediatric lung transplantation is limited by bronchiolitis obliterans (BO), but varieties of chronic lung allograft dysfunction (CLAD) are poorly understood. Restrictive…
  • 2015 American Transplant Congress

    Kidney Transplant Outcomes in Recipients Older Than 70: A Single Center Experience

    M. Yaqub, A. Sharfuddin, M. Mujtaba, D. Mishler, T. Taber, W. Goggins, N. Kassis Akl.

    Indiana University Health, Indianapolis, IN.

    Age is no longer considered a contraindication to renal transplantation. To date, little is known in regards to the grafts and patients outcomes in elderly…
  • 2015 American Transplant Congress

    Measuring Affinity of Polyclonal HLA-Specific Antibodies in Highly Sensitised Cases Can Serve as an Additional Biomarker to Guide Direct Transplantation

    S. Daga,1,2 D. Lowe,6 R. Buchli,3 J. Collard,3 A. Mulder,8 C. McMurtrey,3,4 H. Moyse,7 N. Evans,7 N. Krishnan,2 W. Hildebrand,3,4 F. Claas,8 D. Briggs,5 D. Zehnder,1,2 D. Mithcell,1 R. Higgins.1,2

    1Clinical Sciences Research Laboratories, University of Warwick, Coventry, United Kingdom; 2Renal Unit, University Hospital, Coventry and Warwickshire NHS Trust, Coventry, United Kingdom; 3Pure Protein LLC, Oklahoma; 4University of Oklahoma Health Science Center, Oklahoma City; 5Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Birmingham, United Kingdom; 6Department of Histocompatibility and Immunogenetics, Royal Liverpool University Hospital, Liverpool, United Kingdom; 7School of Engineering, University of Warwick, Coventry, United Kingdom; 8Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.

    Significant numbers of patients on transplant waiting lists in the UK are sensitised (43%). Direct transplantation across these HLA-specific antibodies using risk stratification strategies are…
  • 2015 American Transplant Congress

    Variants Associated With Tacrolimus Troughs in European American Kidney Transplant Recipients: A Genome Wide Association Study

    P. Jacobson,1 M. Miller,2 D. Schladt,3 A. Israni,3 K. Sanghavi,1 C. Dorr,3 R. Remmel,1 W. Guan,4 A. Matas,5 W. Oetting.1

    1College of Pharmacy, University of MN, Minneapolis, MN; 2Department of Psychology, University of MN, Minneapolis, MN; 3Department of Nephrology and Chronic Disease Research Group, Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; 4Department of Biostatistics, University of MN, Minneapolis, MN; 5Department of Surgery, University of MN, Minneapolis, MN.

    Tacrolimus (tac) is dependent on CYP3A4/5 for metabolism. Variability in the metabolism is influenced by CYP3A5*3 alleles. This variant and clinical factors explain around 50%…
  • 2015 American Transplant Congress

    Molecular Testing for Microcirculation Injury Enhances the Assessment of Antibody-Mediated Rejection in Human Cardiac Allograft Biopsies

    B. Afzali,1 E. Chapman,1 B. Adam,1 F. Riesgo Gil,2 D. Kim,2 L. Hidalgo,1 P. Campbell,1 B. Sis,1 M. Mengel.1

    1Dept. of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; 2Div. of Cardiology, University of Alberta, Edmonton, AB, Canada.

    BACKGROUND: Despite continuous attempts to refine diagnostic consensus, accurate assessment of Antibody-mediated rejection (AMR) is an ongoing unmet need. The microcirculation represents the primary target…
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