Am J Transplant, Volume 5, Suppl 3 Archives - Page 91 of 170 - ATC Abstracts

2015 American Transplant Congress
Alloimmune Regulation and Long-Term Allograft Survival Induced by Short-Term Administration of Chinese Medicine Cornus Officinalis and Cuscuta Sinensis Lam
Z. Dai, Y. Zeng, X. Liu, Z. Chuan.
Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong, China.
Achieving long-term allograft survival or tolerance without continuously global immunosuppression is a highly desirable goal. This study is to induce long-term allograft survival without long-term…
2015 American Transplant Congress
Fracture Incidence in Adult Kidney Transplant Recipients
K. Naylor,^1,2 S. Jamal,³ G. Zou,¹ E. McArthur,⁴ N. Lam,^1,2 W. Leslie,⁵ A. Hodsman,² J. Kim,^4,6 G. Knoll,⁷ L.-A. Fraser,¹ J. Adachi,⁸ A. Garg.^1,2,4
¹Western University, London, ON, Canada; ²London Health Sciences Centre, London, ON, Canada; ³Women's College Research Institute, Toronto, Canada; ⁴Institute for Clinical Evaluative Sciences, Toronto, Canada; ⁵University of Manitoba, Winnipeg, Canada; ⁶University Health Network, Toronto, Canada; ⁷Ottawa Hospital Research Institute, Ottawa, Canada; ⁸McMaster University, Hamilton, Canada.
Background: It remains uncertain whether kidney transplant recipients are a high risk group for fracture. We conducted this study to provide a precise estimate of…
2015 American Transplant Congress
Renal Transplantation in Aged Over 60 Years Demonstrates Compatible Clinical Outcomes to Younger Recipients
H. Cho,¹ H. Kim,¹ C. Baeck,¹ H. Yu,¹ D.-J. Han,² M. Jo,³ S.-K. Park.¹
¹Division of Nephrology, Department of Internal Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; ²Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; ³Department of Preventive Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
Introduction: The aim of this study was comparing clinical outcomes of kidney transplantation between aged over 60 years and younger recipientsMethods: From 1993 to 2013,…
2015 American Transplant Congress
Profound Effect of HDAC2 Deletion on Renal Ischemia-Reperfusion Injury Is Intrinsic to the Kidney and Includes Protection Against Cold Ischemia
D. Aufhauser, Jr.,¹ Z. Wang,¹ S. Cheraghlou,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA; ²Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA; ³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Histone/protein deacetylases (HDACs) regulate gene expression by modifying chromatin accessibility and protein acetylation. We have previously found that deletion of HDAC2 protects from renal…
2015 American Transplant Congress
Cellular Mechanism of Enhanced Alloimmunity by Ischemia Reperfusion Injury
Z. Solhjou, M. Uehara, S. Ohori, M. McGrath, J. Azzi, S. Tullius, R. Abdi.
Transplant Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Ischemia reperfusion injury of transplanted organs represents a key pathogenic inflammatory process, which increases their allogenicity; subsequently augmenting the rate of acute and chronic rejection.…
2015 American Transplant Congress
CHBP in Preservation Solution and Autologous Blood Perfusate Ameliorates Ischemia Reperfusion Injury in Isolated Porcine Kidneys
C. Yang,¹ S. Hosgood,² H. Carly,² P. Meeta,² Y. Long,³ T. Zhu,¹ M. Nicholson,² B. Yang.²
¹Urology, Zhongshan Hospital, Fudan University, Shanghai, China; ²Transplant Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, Leicester, China; ³Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Background. There is an imperative need to better preserve isolated organs before transplantation. A non-erythropoiesis cyclic helix B peptide (CHBP) derived from erythropoietin was newly…
2015 American Transplant Congress
Pharmacokinetics of Tacrolimus (TAC) in Elderly Compared to Young Recipients in the First Year After Renal Transplantation. Data from the NEverOLd Trial
E. David-Neto,¹ P. Romano,² A. Triboni,¹ F. Agena,¹ P. Ebner,² F. Ramos,¹ N. Galante,¹ F. Lemos.¹
¹Renal Transplantation Service, Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil; ²Division of Central Laboratory, Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil.
Elderly (≥60years) recipients are nowadays receiving renal transplants more frequently. The pharmacokinetics studies (PK) of immunosuppressive drugs in healthy volunteers, rarely, if ever, include old…
2015 American Transplant Congress
2-Year Results on Renal Function and Safety for Everolimus plus Reduced-Exposure Calcineurin Inhibitor in Living Donor Kidney Transplant Recipients
T. Yagisawa,¹ N. Ishikawa,¹ N. Goto,² I. Nakajima,³ O. Kamisawa,⁴ S. Fuchinoue.³
¹Division of Renal and Transplantation, Jichi Medical University, Shimotsuke, Japan; ²Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ³Surgery, Kidney Center, Tokyo Women's University, Tokyo, Japan; ⁴Medical Division, Novartis Pharma K.K., Tokyo, Japan.
Purpose: The long-term effects of everolimus (EVR) with reduced cyclosporine (rCsA) exposure over 24 months on renal function and safety (viral infection) were assessed in…
2015 American Transplant Congress
Intra-Lymphocyte Concentrations of Mycophenolic Acid Correlate With the Incidence of Early Graft Rejection in Renal Transplant Recipients
Z. Md Dom,² J. Coller,² R. Carroll,³ A. Somogyi,² B. Sallustio.¹
¹Clinical Pharmacology, The Queen Elizabeth Hospital, Adelaide, Australia; ²Discipline of Pharmacology, Univeristy of Adelaide, Adelaide, Australia; ³Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, Australia.
Introduction: Although routine therapeutic drug monitoring of mycophenolic acid (MPA) concentrations in plasma has been recommended to individualize MPA doses in transplant recipients, little is…
2015 American Transplant Congress
Reassessing Tubulitis and Interstitial Infiltrate: Creating a New Probabilistic Definition of TCMR
P. Halloran, I. Salazar, M. Lopez, J. Chang.
Alberta Transplant Applied Genomics Centre, Edmonton, Canada.
Conventional diagnosis of T cell-mediated rejection (TCMR) in kidney transplant biopsies relies on interstitial inflammation (i-lesions), tubulitis (t-lesions), vasculitis (v-lesions) and experience-derived interpretation rules. The…