Am J Transplant, Volume 5, Suppl 3 Archives - Page 87 of 170 - ATC Abstracts

2015 American Transplant Congress
Early Allograft Dysfunction Causes Inferior Patient and Allograft Survival in Liver Transplantation; an Experience of 1952 Consecutive Liver Transplants
D. Lee, K. Croome, J. Burns, D. Perry, J. Nguyen, H. Crespo, C. Taner.
Transplantation, Mayo Clinic, Jacksonville, FL.
Background: Early allograft dysfunction (EAD) in liver transplantation (LT) is a useful intermediate outcome measure to predict graft loss or mortality. We sought to investigate…
2015 American Transplant Congress
Broader Geographic Sharing of Adolescent Lung Donors Improves Allocation Efficiency
W. Tsuang,¹ J. Pyke,² M. Skeans,² K. Chan,⁴ T. Wozniak,³ A. Israni,² M. Hertz,⁴ B. Kasiske,² M. Valapour,¹ J. Snyder.²
¹Cleveland Clinic, Cleveland, OH; ²SRTR, MMRF, Minneapolis, MN; ³IN University, Indianapolis, IN; ⁴University of MI, Ann Arbor, MI; ⁵University of MN, Minneapolis, MN.
Allocating pediatric donor lungs to pediatric lung transplant (TXP) candidates results in better graft function. However, 87% of adolescent (ADL) donor lungs are allocated to…
2015 American Transplant Congress
Sequential Monitoring and Stability of Ex Vivo-Expanded Autologous and Non-Autologous Regulatory T Cells Following Infusion in Non-Human Primates
H. Zhang,¹ H. Guo,¹ L. Lu,¹ A. Zahorchak,¹ R. Wiswman,² G. Raimondi,¹ D. Cooper,¹ M. Ezzelarab,¹ A. Thomson.¹
¹University of Pittsburgh, pittsburgh, PA; ²University of Wisconsin, Madison.
Ex vivo-expanded cynomolgus monkey CD4+CD25+CD127- regulatory T cells (Treg) maintained Foxp3 demethylation status at the Treg-Specific Demethylation Region (TSDR), and potently suppressed T cell proliferation…
2015 American Transplant Congress
Plasma Levels of Donor-Derived Cell-Free DNA Increase With Rejection and Often Decrease After Treatment in Organ Transplant Recipients
M. Grskovic,¹ J. Beausang,¹ D. Hiller,¹ R. Sit,¹ B. Christie,¹ J. Elechko,¹ R. Woodward,¹ J. Yee,¹ J. Kobashigawa.²
¹CareDx, Inc, Brisbane, CA; ²Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a potential biomarker of acute cellular rejection (ACR) in organ transplant recipients. dd-cfDNA levels in longitudinal plasma samples from…
2015 American Transplant Congress
Outcome of Bortezomib/Plasmapheresis for the Sensitized Patient Awaiting Heart Transplant
J. Patel, N. Reinsmoen, M. Kittleson, D. Dilibero, F. Liou, D. Chang, M. Hamilton, L. Czer, F. Esmailian, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles, CA.
Purpose: Allosensitization of patients (pts) awaiting heart transplantation is a significant challenge as it prolongs the time to transplant, increases wait-list mortality and increases risk…
2015 American Transplant Congress
Aquaporin 4 Blockade Is a Novel Strategy Targeting Ischemia/Reperfusion Injury in Heart Transplantation
K. Ayasoufi,¹ N. Kohei,¹ G. Farr,² P. McGuirk,² M. Pelletier,² R. Fairchild,¹ A. Valujskikh.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Aeromics, LLC, Cleveland, OH.
Aquaporin 4 (AQP4) belongs to the family of small integrin transmembrane proteins that are highly permeable to water. It was recently shown that human and…
2015 American Transplant Congress
Impact of Community Risk on Early Hospital Readmission Following Kidney Transplant
E. King,¹ L. Kucirka,¹ M. McAdams-DeMarco,^1,2 A. Massie,^1,2 J. Schold,³ D. Segev.^1,2
¹Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD; ²Epidemiology, Johns Hopkins University, School of Public Health, Baltimore, MD; ³Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.
Background: Early hospital readmission (EHR) is associated with increased morbidity, mortality, and cost in kidney transplantation (KT). Community risk may be associated with EHR above…
2015 American Transplant Congress
Robotic Kidney Transplantation With Regional Hypothermia: Results from a Prospective Two-Arm Non-Randomized Controlled Trial (Ideal Phase 2b)
R. Ahlawat,¹ A. Sood,² P. Ghosh,¹ V. Kher,¹ M. Bhandari,² M. Menon.²
¹Institute of Kidney and Urology, Medanta, the Medicity, Gurgaon, Haryana, India; ²Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI.
ObjectivesMinimally-invasive approaches to kidney transplantation are up-coming. We recently developed and described a novel technique of robotic KT (RKT) using intra corporeal graft cooling. Here,…
2015 American Transplant Congress
Donor Specific Antibodies (DSA) Increase the Risk for Rejection After Pancreas Transplantation Qithout Negatively Impacting Survival
M. Marquez, M. Dib, G. Sapisochin, J. Laurence, A. Barbas, F. Bazerbachi, A. Norgate, M. Selzner, P. Greig, I. McGilvray, M. Cattal.
Multi-Organ Transplant, University Health Network, Toronto, ON, Canada.
Donor-specific antibodies (DSA) have been associated with increased rejection and lower kidney transplant survival. The impact of DSA on pancreas transplant outcomes in patients with…
2015 American Transplant Congress
TGFβ Production By B Cells Is Critical for Transplant Tolerance Induction
J. Kim,¹ W. Liu,^1,2 L. Liu,^1,2 K. Lee,¹ R. Stott,¹ H. Yeh,¹ J. Markmann.¹
¹Surgery, Massachusetts General Hospital / Harvard Medical School, Boston, MA; ²Surgery, Chengdu Military General Hospital, Chengdu, Sichuan, China.
Regulatory B cells (Bregs) have been shown to play a critical role in immune homeostasis and in autoimmunity models. We have recently demonstrated that combined…