ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Robotic Kidney Transplantation in Obese Recipients Can Lead to Superior Outcomes in Terms of Wound Infection and Graft Survival

    I. Tzvetanov, G. D'Amico, G. Georgiev, P. Giulianotti, H. Jeon, R. Garcia-Roca, J. Oberholzer, E. Benedetti.

    Surgery, Division of Transplantation, University of Illinois at Chicago, Chicago, IL.

    IntroductionTraditionally kidney transplantation (KT) in obese recipients has been associated with high rates of surgical site infections (SSI). We hypothesize that robotic kidney transplantation (RKT)…
  • 2015 American Transplant Congress

    Optimal Induction Therapy (IT) in Pancreas After Kidney Transplantation (PAK) According to Type of Kidney (kd) Donor and Patient Risk – A Registry Analysis

    R. Gruessner,1 A. Gruessner.2

    1University of Arizona, Tucson, AZ; 2University of Arizona, Tucson, AZ.

    Purpose: Best IT in PAK recipients (rec) according to type of kd donor (LD vs. DD) and rec risk has not been determined.Methods: Using the…
  • 2015 American Transplant Congress

    Tolerance to Graft A-Antigens Following ABO-Incompatible Heart Transplantation (HTx) in a Blood Group A-Transgenic Mouse Model

    B. Motyka,1 K. Labonte,1 F. Rahman,1 J. Pearcey,1 K. Tao,1 M. Mengel,1 B. Sis,1 P. Cowan,2 L. West.1

    1Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada; 2Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia.

    Purpose: ABOi HTx can be performed safely in infants when ABO antibody (Ab) levels are low or absent. Following ABOi HTx, immune tolerance develops to…
  • 2015 American Transplant Congress

    The Effect of Rituximab Therapy on Regulatory B Cell and Prevention of Chronic Antibody Mediated Rejection in Kidney Transplantation Recipients

    M. Ikemiyagi, R. Ishii, S. Miyairi, T. Hirai, K. Omoto, K. Tanabe.

    Urology, Tokyo Women's Medical University, Tokyo, Japan.

    We previously reported that a single administration of low dose rituximab (RIT) before kidney transplant reduced the incidence rate of chronic antibody mediated rejection (CAMR)…
  • 2015 American Transplant Congress

    Structure/Function Insights Into Treg Biology: Hdac11 Is a Foxp3 Deacetylase Whose Targeting Promotes and Stabilizes Foxp3 Expression and Leads to Long-Term Allograft Survival

    J. Huang,1 L. Wang,1 T. Bhatti,1 A. Samanta,1 S. Dahiya,1 R. Han,1 J. Bergman,2 A. Kozikowski,2 W. Hancock.1

    1CHOP & UPenn, Philadelphia; 2Uni of Illinois at Chicago, Chicago.

    Aim: There are huge scientific, economic and practical advantages in developing pharmacologic approaches to enhance Foxp3+ Treg function in allograft recipients versus simply injecting enormous…
  • 2015 American Transplant Congress

    Preemptive Deceased Donor Transplant With Kidney Donor Profile Index Scores Greater Than 85 Not Associated With a Survival Benefit

    D. Keith, A. Nishio Lucar, G. Vranic.

    University of Virginia, Charlottesville, VA.

    Preemptively listed candidates for kidney transplant are a unique patient population with regard to marginal quality kidney acceptance as they are not yet dialysis dependent.…
  • 2015 American Transplant Congress

    Clinical and Pathologic Predictors of Response to Belatacept Conversion

    S. Patel, H. Morris, D. Cohen, S. Mohan, L. Ratner, R. Crew.

    Columbia Universtiy, New York.

    INTRO: Calcineurin inhibitors have improved kidney transplant and recipient survival, their use has significant nephrotoxicity. Belatacept is a recently approved immunosuppressant that is not nephrotoxic…
  • 2015 American Transplant Congress

    T Cell C5a Receptor (C5aR) Signaling Regulates T Follicular Helper Cell (Tfh) Induction

    D. Verghese, P. Heeger.

    Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY.

    Tfh cells, in part via IL-6 dependent production of IL-21, are specialized providers of B cell help. Extending previous work in which we showed that…
  • 2015 American Transplant Congress

    Immunological Characterization of Full Facial Transplant Recipients

    T. Borges,1 J. Azzi,1 S. Tullius,1 A. Chandraker,1 B. Pomahac,2 N. Najafian,1 L. Riella.1

    1Transplant Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston; 2Plastic Surgery, Boston.

    Background: Despite the skin being considered the most immunogenic of all human tissues, full facial transplantation (FFT) has become a life transforming procedure with encouraging…
  • 2015 American Transplant Congress

    Pre-Transplant Angiotensin Receptor II Type 1 Antibodies (AT1R) and Serum Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) as Predictors of Post Transpalnt FSGS Recurrence

    A. Khalil, T. Tim, A. Sharfuddin, S. Doshi, M. Yaqub, D. Mishler, W. Goggins, M. Mujtaba.

    Indiana University school of Medicine-IU Health Transplant, Indianapolis, IN.

    Approximately 30% of renal transplant patients develop recurrence of FSGS in the first kidney allograft. AT1R is expressed on podocytes; its expression is elevated in…
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