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American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Impact of Community Risk on Early Hospital Readmission Following Kidney Transplant

    E. King,1 L. Kucirka,1 M. McAdams-DeMarco,1,2 A. Massie,1,2 J. Schold,3 D. Segev.1,2

    1Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD; 2Epidemiology, Johns Hopkins University, School of Public Health, Baltimore, MD; 3Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.

    Background: Early hospital readmission (EHR) is associated with increased morbidity, mortality, and cost in kidney transplantation (KT). Community risk may be associated with EHR above…
  • 2015 American Transplant Congress

    Robotic Kidney Transplantation With Regional Hypothermia: Results from a Prospective Two-Arm Non-Randomized Controlled Trial (Ideal Phase 2b)

    R. Ahlawat,1 A. Sood,2 P. Ghosh,1 V. Kher,1 M. Bhandari,2 M. Menon.2

    1Institute of Kidney and Urology, Medanta, the Medicity, Gurgaon, Haryana, India; 2Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI.

    ObjectivesMinimally-invasive approaches to kidney transplantation are up-coming. We recently developed and described a novel technique of robotic KT (RKT) using intra corporeal graft cooling. Here,…
  • 2015 American Transplant Congress

    Donor Specific Antibodies (DSA) Increase the Risk for Rejection After Pancreas Transplantation Qithout Negatively Impacting Survival

    M. Marquez, M. Dib, G. Sapisochin, J. Laurence, A. Barbas, F. Bazerbachi, A. Norgate, M. Selzner, P. Greig, I. McGilvray, M. Cattal.

    Multi-Organ Transplant, University Health Network, Toronto, ON, Canada.

    Donor-specific antibodies (DSA) have been associated with increased rejection and lower kidney transplant survival. The impact of DSA on pancreas transplant outcomes in patients with…
  • 2015 American Transplant Congress

    TGFβ Production By B Cells Is Critical for Transplant Tolerance Induction

    J. Kim,1 W. Liu,1,2 L. Liu,1,2 K. Lee,1 R. Stott,1 H. Yeh,1 J. Markmann.1

    1Surgery, Massachusetts General Hospital / Harvard Medical School, Boston, MA; 2Surgery, Chengdu Military General Hospital, Chengdu, Sichuan, China.

    Regulatory B cells (Bregs) have been shown to play a critical role in immune homeostasis and in autoimmunity models. We have recently demonstrated that combined…
  • 2015 American Transplant Congress

    Process Deviation Tracking and Analysis in an Organ Procurement Organization

    B. Schleich,1 S. Yoon,1 M. Khasawneh,1 K. Srihari,1 H. Irving,2 A. Friedman.

    1Systems Science and Industrial Engineering, State University of New York at Binghamton, Binghamton, NY; 2New York Organ Donor Network, New York, NY.

    "It is common practice for Organ Procurement Organizations (OPOs) to report, collect and track issues and problems occurring during the organ donation process. We labeled…
  • 2015 American Transplant Congress

    MicroRNA let-7i Targeting IL-10 Via JAK1-STAT3 Signal Pathway Regulates Dendritic Cells Maturation Subsequently Induces Cardiac Allograft Tolerance

    J. Wu,2,3 X. Jin,1 Y. Sun,2,3 X. Liu,2,3 D. Chi,2,3 B. Yu.2,3

    1Thoracic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China; 2Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; 3Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

    Background: Our previous study demonstrated that microRNA (MiR) let-7i could regulate dendritic cells (DCs) maturation and functional state via targeting SOCS1. In this study, we…
  • 2015 American Transplant Congress

    Development of a Targeted Genetic Renal Disease Panel With NexGen Sequencing for Unbiased Testing of Living Kidney Donors for Genetic Kidney Disease

    C. Thomas,1 Z. Stewart,3 A. Mansilla,2 S. Mason,2 A. Kwitek,2 C. Campbell,2 R. Smith,1,2 R. Smith.1,2

    1Internal Medicine, University of Iowa, Iowa City, IA; 2Institute of Human Genetics, University of Iowa, Iowa City, IA; 3Surgery, University of Iowa, Iowa City, IA.

    Recent studies indicate that living donors biologically related to their transplant recipient may be at higher risk of ESRD compared to unrelated donors, possibly secondary…
  • 2015 American Transplant Congress

    The Extended Toronto Criteria for Transplantation for Hepatocellular Carcinoma. A Validation Study

    G. Sapisochin, N. Goldaracena, J. Laurence, M. Dib, A. Barbas, A. Ghanekar, L. Lilly, E. Renner, M. Selzner, M. Cattral, I. McGilvray, D. Grant, P. Greig.

    Multi-Organ Transplant, Toronto General Hospital. University of Toronto, Toronto, ON, Canada.

    Liver transplant (LT) listing criteria for patients with hepatocellular cancers (HCC) that exceed the Milan criteria are still controversial. At the University of Toronto, we…
  • 2015 American Transplant Congress

    BAFF Binding to T Cell-Expressed BAFF-R Promotes Follicular Helper T Cell Proliferation and GC B Cell Responses

    M. Chen,1 Q. Li,1 W. Stohl,2 S. Zheng,2 X. He,1 Z. Guo.1

    1Organ Transplant Center, 1st affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; 2Division of Rheumatology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA.

    Recent studies have defined a crucial role for the B cell–activating factor belonging to TNF family (BAFF) in promoting germinal center (GC) responses in mouse…
  • 2015 American Transplant Congress

    Concerted T-Cell Activity Against Early and Late BKV-Antigens Is Necessary for Viral Clearance

    B. Weist,1,2 M. Schmueck,2 M. Dziubianau,2 P. Reinke,1,2 N. Babel.1,2

    1Department of Nephrology, Charite Universitaetsmedizin, Berlin, Germany; 2BCRT, Charite Universitaetsmedizin, Berlin, Germany.

    Polyomavirus-BK (BKV) associated nephropathy is a known cause of graft failure. No specific therapy is established so far and viral load monitoring accompanied by adjustment…
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