Am J Transplant, Volume 5, Suppl 3 Archives - Page 81 of 170 - ATC Abstracts

2015 American Transplant Congress
Does DSA Market Competition Influence OPO Performance?
J. Adler,¹ H. Yeh,¹ J. Markmann,¹ L. Nguyen,² D. Axelrod.³
¹Surgery, Massachusetts General Hospital, Boston, MA; ²Surgery, Brigham and Women's Hospital, Boston, MA; ³Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH.
INTRODUCTION: Increased market competition within a Donor Service Area (DSA) is associated with a greater number of liver and kidney transplants, but its effect on…
2015 American Transplant Congress
Living Donor Characteristics Associated With Changes in Post-Donation GFR
E. Poggio,¹ D. Mandelbrot,⁴ P. Reese,⁵ D. Goldfarb,³ S. Flechner,³ J. Schold.²
¹Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH; ²Qualitative Health Sciences, Cleveland Clinic, Cleveland, OH; ³Urology, Cleveland Clinic, Cleveland, OH; ⁴Division of Medicine, University of Wisconsin, Madison, WI; ⁵Nephrology, University of Pennsylvania, Philadelphia, PA.
Living donor transplantation is the preferred modality for treatment of ESRD because it confers excellent outcomes for recipients and poses reasonable risks to most donors.…
2015 American Transplant Congress
Galectin-9 Protects Mouse Liver Transplants Against Ischemia-Reperfusion Injury
H. Ji, Y. Liu, Y. Zhang, X. Shen, F. Gao, R. Busuttil, J. Kupiec-Weglinski.
Dept of Surgery, Dumont-UCLA Liver Transplant Center, Los Angeles, CA.
Background:Although Galecin 9 (Gal-9) negatively regulates Th1-type alloimmunity by binding to T-cell Immunoglobulin Mucin-3 (TIM-3) on activated Th1 cells, its role in liver ischemia-reperfusion injury…
2015 American Transplant Congress
Activated T Regulatory Cells Escape Death by Increasing Cytoplasmic Serine Protease Inhibitor 6 (SPI6)
A. Radwan, M. Uehara, P. Lukyanchykov, L. Riella, A. Chandraker, R. Abdi, J. Azzi.
Renal/ Transplantation Research Center, Brigham and Women's Hospital, Boston, MA.
Regulatory T cells (Tregs) can employ a granzyme B (GrB)-dependent mechanism to mediate suppression of effector cells by inducing their apoptosis. In this study we…
2015 American Transplant Congress
Th17 Mediates Inflammatory Responses After Lung Transplantation
J. Xu,¹ L. Wang,¹ Q. Chen,² S. Xia,¹ X. Li,¹ H. Li,² Y. Ding.^1,3
¹Department of Immunology, Capital Medical University, Beijing, China; ²Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; ³Department of Respiratory Diseases, Capital Medical University, Beijing, China.
Background: Long-term outcomes after lung transplantation are markedly worse than for other organs. The mechanisms that determine lung transplant rejection are not clear. The role…
2015 American Transplant Congress
Elevated ST2 Levels Are Associated With Increased Risk of Antibody Mediated Rejection in Heart Transplant Recipients
A. Grupper,¹ S. Kushwaha,¹ O. Abou Ezzeddine,¹ J. Geske,² W. Kremers,² B. Edwards,¹ N. Pereira.¹
¹Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN; ²Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
Objective: Serum ST2, a member of the interleukin (IL) 1 receptor family, is a novel biomarker that reflects cardiac remodeling and fibrosis and is associated…
2015 American Transplant Congress
Distinct Blood and Biopsy Meta-Signatures for Acute Rejection Post Kidney Transplant
W. Zhang,¹ Z. Yi,¹ Z. Li,¹ M. Menon,¹ L. Li,¹ C. Xi,¹ I. Greene,¹ C. Wei,¹ L. Gallon,² M. Samaniego,³ A. Djamali,⁴ S. Alexander,⁵ B. Schroppel,¹ B. Nankivell,⁵ J. Chapman,⁵ I. Rosales,⁶ R. Neal Smith,⁶ R. Colvin,⁶ P. O'Connell,⁵ P. Heeger,¹ B. Murphy.¹
¹Icahn School of Medicine at Mount Sinai, New York; ²North Western University, Chicago; ³University of Michigan, Michigan; ⁴University of Wisconsin, Madison; ⁵The University of Sydney, Sydney, Austria; ⁶Massachusetts General Hospital, Boston.
Acute rejection (AR) is a major cause of allograft dysfunction. Molecular signatures of AR from blood and biopsy have been identified by several independent cohort…
2015 American Transplant Congress
Etiology, Incidence and Outcomes of the Highly Sensitized Kidney Transplant Patient
R. Redfield, T. Zens, J. Scalea, M. Rizzari, D. Mandelbrot, D. Kaufman, A. Djamali.
University of Wisconsin, Madison, WI.
Background: Sensitization to HLA antigens is a major barrier to kidney transplantation. We sought to determine the etiology, incidence and outcomes of kidney transplants performed…
2015 American Transplant Congress
Reduced Incidence of Cytomegalovirus Infection in Kidney Transplant Recipients Receiving Everolimus
H. Tedesco-Silva,¹ C. Felipe,¹ A. Ferreira,¹ M. Cristelli,¹ T. Sandes- Freitas,¹ N. Oliveira,¹ W. Aguiar,² G. Bassos,¹ M. Franco,³ M. Gerbase- Lima,⁴ E. Campos,⁴ J. Medina-Pestana.¹
¹Nephrology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ²Urology, Hospital do Rim UNIFESP, Sao Paulo, Brazil; ³Pathology, UNIFESP, Sao Paulo, Brazil; ⁴Immunogenetic, AFIP, Sao Paulo, Brazil.
BACKGROUND: CMV infection is associated with inferior long-term kidney transplant outcomes. This study compared the incidence of CMV infection/disease in de novo kidney transplant recipients…
2015 American Transplant Congress
Pancreas Transplantation Immunosuppression Induction With Rabbit Antithymocyte Globulin +/- Rituximab and Early Steroid Withdrawal: Experience With >500 Recipients
J. Fridell,¹ R. Mangus,¹ J. Chen,² M. Mujtaba,³ T. Taber,³ M. Goble,¹ J. Powelson.¹
¹Surgery, Indiana University School of Medicine, Indianapolis, IN; ²Pharmacy, Indiana University School of Medicine, Indianapolis, IN; ³Medicine, Indiana University School of Medicine, Indianapolis, IN.
T-cell depleting antibody induction, often combined with steroid withdrawal, has become standard practice for pancreas transplantation. In this study, outcomes of >500 pancreas transplants using…