Am J Transplant, Volume 5, Suppl 3 Archives - Page 78 of 170 - ATC Abstracts

2015 American Transplant Congress
Immunomodulation of Human T Cells by a Novel RALG Preparation With Higher Specificity Toward Activating T Cells
K. Samy, H. Xu, A. Kirk.
Surgery, Duke University Medical Center, Durham, NC.
Current induction therapy using thymoglobulin (ATG) results in nonspecific T cell depletion. We have generated a polyclonal rabbit anti-human leukocyte globulin (RALG) by immunizing rabbits…
2015 American Transplant Congress
Thymic Transplantation to Determine Mechanisms of Thymic Involution: Insulin-Like Growth Factor 1 Receptor and Forkhead Box Protein N1 in the Thymus Play a Role in Maintaining the Juvenile Thymus
K. Yamada, M. Tasaki, M. Sekijima, A. Kawai, V. Villani, T. Tanabe, I. Hanekamp, A. Shimizu, D. Sachs.
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boton, MA.
Thymic involution has long been associated with age-related changes of the immune system, although the cause remains unclear. We have extensively studied the role of…
2015 American Transplant Congress
Immunodeficiency Assessment in Pediatric Intestinal Failure Patients
J. Garcia,¹ T. Beduschi,¹ C. Biaggi,² E. Perez,² A. Tekin,¹ M. McGetrick,³ L. Cubley,¹ P. Ruiz,¹ J. Fan,¹ S. Nishida,¹ G. Selvaggi,¹ R. Vianna.¹
¹Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL; ²Pediatrics, University of Miami Miller School of Medicine, Miami, FL; ³University of Miami Miller School of Medicine, Miami, FL.
Intestinal failure (IF) is a clinical condition for which intestinal transplantation may be indicated. Patients without enteral autonomy have an increased risk of malnutrition which…
2015 American Transplant Congress
Clinical and Immunologic Risk Factors Associated With Donor-Specific Antibody (DSA) Formation Following Renal Transplantation
C. Johnson,¹ S. Park,¹ J. Schiller.²
¹Department of Surgery, Medical College of Wisconsin, Milwaukee, WI; ²Blood Center of Wisconsin, Milwaukee, WI.
Background: De novo DSA formation is emerging as an important risk factor for adverse graft outcomes following renal transplantation. Specific pretransplant risk factors for DSA…
2015 American Transplant Congress
Evaluation of Medication Regimen Complexity Over Time Following Heart Re-Transplantation
B. Bryant,¹ A. Libby,¹ R. Page,¹ J. Lindenfeld,² C. Aquilante.¹
¹University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO; ²University of Colorado School of Medicine, Aurora, CO.
Medication regimen complexity (MRC) includes many characteristics of a drug regimen. Previously, we showed that MRC is high and persists over time after primary heart…
2015 American Transplant Congress
Interleukin-17A Induced Human Mesenchymal Stem Cells Are Superior Modulators of Immunological Function
K. Sivanathan,^1,2,3 D. Rojas-Canales,^1,2 S. Grey,⁵ C. Hope,^1,2 R. Carroll,^1,4 S. Gronthos,^3,6 P. Coates.^1,2,3,4
¹Centre for Clinical and Experimental Transplantation, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ²School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; ³Centre for Stem Cell Research, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia; ⁴Central Northern Adelaide Renal Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ⁵Transplantation Immunology Group, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia; ⁶Mesenchymal Stem Cell Laboratory, School of Medical Sciences, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Interferon-gamma preactivated mesenchymal stem cells (MSC-γ) are highly immunosuppressive but immunogenic in vivo due to their inherent expression of major histocompatibility (MHC) molecules. We modified…
2015 American Transplant Congress
Marrow Mesenchymal Stem Cells Attenuate Immune Rejection in Murine Lung Allograft
X. Zhang,¹ Y. Gong,² K. Jiang,² C. Wang,² T. Xia,² J. Li,² J. Wang,² J. Nie.²
¹Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China; ²Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
Objectives:The inherent immunosuppressive properties and low immunogenicity of mesenchymal stems cells (MSCs) suggested their therapeutic potential in transplantation. In this study we investigated if systematic…
2015 American Transplant Congress
Delivery of Heme Oxygenase-1-Cell Penetrating Peptide (HO-1-CPP) Into Hepatocytes, Kupffer and Islet Cells in In Vitro and Ex Vivo Models of Cold Ischemia
A. Venkatachalam,¹ C. Wood,¹ Q. Hu,¹ I. Alwayn.²
¹Surgery, Dalhousie University, Halifax, NS, Canada; ²Surgery, Pathology, Microbiology & Immunology, Surgical Lead Multi Organ Transplant Program, QEII Health Sciences Center, Dalhousie University, Halifax, NS, Canada.
In an attempt to increase the number of donor organs available to transplantation extended criteria donor (ECD) organs are more frequently considered. Unfortunately, ECD organs…
2015 American Transplant Congress
Remote Ischemic Perconditioning Induces Protection Against Hepatic Ischemia/Reperfusion Injury in Rats Via Downregualtion of Bax and Cleaved Caspase-3 Expression
H. Ahn, M. Park, S. Joo, B. Kim.
Department of Surgery, Kyung Hee University, Seoul, Korea.
Purpose: The aim of this study was to determine whether remote ischemic preconditioning (rPeC) method can protect the hepatic IR injury in rat or not…
2015 American Transplant Congress
Mitochondrial Feedback Mechanisms in Kidney Cell Senescence
K. De Vusser,¹ K. Hochstenbach,² E. Winckelmans,² E. Lerut,³ D. Kuypers,¹ T. Nawrot,² M. Naesens.¹
¹Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium; ²Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium; ³Department of Pathology, University Hospitals Leuven, Leuven, Belgium.
BackgroundProgressive DNA damage (telomere attrition) is considered one of the key instigators of ageing. Different models for ageing where DNA damage leads to accelerated senescence…