ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Refinement of Non-Invasive Diagnostic Criteria to Differentiate Tumor from Bland Portal Vein Thrombosis Before Liver Transplant in Patients With Hepatocellular Carcinoma

    C. Sherman, S. Behr, J. Dodge, J. Roberts, F. Yao, N. Mehta.

    University of California San Francisco, San Francisco, CA.

    Differentiating tumor vs bland portal vein thrombosis (PVT) is essential in determining liver transplant (LT) candidacy for patients with hepatocellular carcinoma (HCC). The primary aim…
  • 2015 American Transplant Congress

    Germinal Centre Autoimmunity Mediates Progression of Allograft Vasculopathy, With Essential Help Provided By T Follicular Cells

    M. Qureshi, R. Motallebzadeh, M. Chhabra, M. Negus, S. Rehakova, E. Bolton, J. Bradley, G. Pettigrew.

    Dept of Surgery, University of Cambridge, Cambridge, United Kingdom.

    Introduction: : In our previous work we have shown that donor CD4 T cells within heart grafts initiate anti-nuclear autoantibody responses. Here we clarify the…
  • 2015 American Transplant Congress

    Vascularized Bone Marrow Plays a Critical Role in Inducing Tolerance of Osteomyocutaneous Allografts

    C.-H. Lin,1 M. Anggelia,1 Y.-L. Wang,1 H.-Y. Cheng,1 W. Lee,2 G. Brandacher.2

    1Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taipei, Taiwan; 2Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

    Background: Vascularized composite allograft (VCA) that includes medullary bone may provide proposed benefits ofvascularized bone marrow transplantation (VBMT), such as a continuous supply of donor…
  • 2015 American Transplant Congress

    1-Year Safety and Efficacy of Eculizumab in Adult aHUS Patients, With or Without a History of Renal Transplant

    C. Legendre,1 J. Kincaid,2 C. Bedrosian,2 C. Loirat.3

    1University Paris Descartes & Hôpital Necker, Paris, France; 2Alexion, Cheshire, CT; 3Assistance Publique–Hôpitaux Paris, Hôpital Robert-Debré, Paris, France.

    Background: Atypical hemolytic-uremic syndrome (aHUS) is a life-threatening, chronic disease of complement-mediated TMA. In aHUS, renal transplantation is associated with post-transplant (TP) TMA and ∼50–70%…
  • 2015 American Transplant Congress

    Impact of Elevated BMI on Allograft Outcomes: A Competing Risks Regression Analysis

    A. Naik, A. Sakhuja, M. Samaniego, P. Shrivastava, D. Cibrik.

    Section of Nephrology, University of Michigan, Ann Arbor, MI.

    INTRODUCTION: Extremes of BMI has been associated with an increased risk of death censored allograft failure. Traditionally the KM product limit estimate has been used…
  • 2015 American Transplant Congress

    The Impact of Acute Rejection on Liver Transplant Survival in the New Millennium

    J. Levitsky,1 S. Forney,2 B. Gillespie,3 R. Merion,2,3 A. Lok,3 G. Levy,4 L. Kulik,1 M. Abecassis,1 A. Shaked.5

    1Northwestern U, Chicago, IL; 2Arbor Research Collaborative for Health, Ann Arbor, MI; 3U Michigan, Ann Arbor, MI; 4U Toronto, Toronto, ON, Canada; 5U Pennsylvania, Philadelphia, PA.

    Background: Based on pre-2000 data, acute rejection (AR) has long been considered clinically less significant in liver transplant (LT) vs. other organ recipients (Charlton et…
  • 2015 American Transplant Congress

    Post-Transplant Lymphoproliferative Disorders Following Alemtuzumab Induction in Kidney Transplantation

    H. Sawhney, R. Charif, J. Galliford, A. Mclean, D. Taube.

    Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, England, United Kingdom.

    Post-Transplant Lymphoproliferative Disorder (PLTD) is a well-recognised serious complication in renal transplant recipients. Induction with lymphocyte depleting agents such as thymoglobulin has been associated with…
  • 2015 American Transplant Congress

    MDSC Derived from iPS Cells Regulate the CD8 T Cell Response In Vivo

    D. Joyce,1 M. Morita,2 X.-K. Li,3 J. Fung,1 S. Qian,1,2 L. Lu.1,2

    1General Surgery, Digestive Disease Institute; 2Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; 3Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.

    Myeloid derived suppressor cells (MDSC) may represent a therapeutic tool for inducing tolerance in transplantation and autoimmune disorders. MDSC propagated from bone marrow (BM) can…
  • 2015 American Transplant Congress

    Deleterious Effects in Kidney Transplant Outcomes With Pre-Organ Procurement Iodine Contrast Exposure

    F. Barrantes,1 S. Stith.2

    1Renal Medicine Associates/Presbyterian Transplant Center, Albuquerque, NM; 2Department of Economics, University of New Mexico, Albuquerque, NM.

    Background: Iodine contrast exposure is well known to cause acute kidney injury. When contrast exposure is added to hemodynamic ischemic injury its adverse effects on…
  • 2015 American Transplant Congress

    Th-17 Alloimune Responses in Renal Allograft Biopsies from Recipients of Kidney Transplants Using Extended Criteria Donors During Acute T-Cell Mediated Rejection

    M. Matignon,1,2 A. Aissat,3 F. Canoui-Poitrine,4 C. Grondin,2 D. Desvaux,5 D. Saadoun,6 P. Lang,1,2 J. Cohen,2 P. Grimbert.1,2

    1Nephrology Transplantation, APHP, Créteil, France; 2U955 Team 21, INSERM, Créteil, France; 3U955 Team 11, INSERM, Créteil, France; 4Public Health, APHP, Créteil, France; 5Anatomopathology, APHP, Créteil, France; 6Internal Medicine, APHP Pitié Salpêtrière, Paris, France.

    Although renal transplantation using expanded criteria donors has become a common practice, immune responses related to immunosenescence in those kidney allografts have not been studied…
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