2015 American Transplant Congress
Frailty and Length of Stay in KT Recipients
BACKGROUND: In KT recipients, length of stay (LOS) is associated with early hospital readmission; yet, predictors of KT LOS are unclear.METHODS: Registry-based predictors of KT…2015 American Transplant Congress
Structural and Functional Basis for Non-HLA Antibody Mediated AT1R Activation
Nephrology and Intensive Care Medicine, Charité University Hospital, Berlin, Germany.
Angiotensin II type receptor (AT1R), a heptahelical protein signals stimuli upon binding of natural peptide ligand angiotensin II (Ang II) and the pathogenic non-HLA IgG…2015 American Transplant Congress
Pharmacogenomic Predictors of Acute Rejection in Kidney Transplant Recipients Identified Using a DNA Biobank Linked to Electronic Medical Records
Purpose: Risk for acute rejection (AR) complicating transplant immunosuppression may be affected by frequent variants in pharmacogenes. Using a DNA biobank linked to electronic medical…2015 American Transplant Congress
The Role of an Intragraft Vascularized Bone Marrow Niche in Establishing Mixed Chimerism and Allograft Acceptance
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD.
Background: Vascularized composite allotransplantation has emerged as a viable treatment option for patients with devastating tissue loss not amenable to traditional reconstructive techniques. Different from…2015 American Transplant Congress
Infusion of Human Factor 7a Restores Circulating Platelets and Prevents TMA in Pig-to-Baboon Liver Xenotransplantation
Background We sought to determine the effects of exogenous administration of human coagulation factors in a pig-to-baboon model of liver xenotransplantation (LXT).Methods LXT was performed…2015 American Transplant Congress
The Immunogenic Perlecan Fragment LG3 Is Released Through Apoptotic Extracellular Vesicles Downstream of Caspase-3 Activation
LG3, a C-terminal fragment of perlecan, has been implicated in aggravation of renal allograft rejection and vascular injury. LG3 is known to be produced at…2015 American Transplant Congress
Combined Anti-IL6R and CTLA4Ig Therapy Attenuates Recall Alloantibody Responses in a Mouse Model of HLA Sensitization
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
[bald]Background[/bald] We previously reported that IL-6 inhibition by anti-IL6R antibody (mMR16-1) or CD28 pathway inhibition using CTLA4Ig (abatacept) reduced recall alloantibody responses in a mouse…2015 American Transplant Congress
Frailty in Patients Being Evaluated for Kidney Transplantation
BACKGROUND: In patients undergoing hemodialysis, frailty prevalence is high and predicts mortality and hospitalization. Little is known about frailty in patients with ESRD who are…2015 American Transplant Congress
Long-Term Outcomes of Transplantation Using Kidneys from Expanded Criteria Donors
BackgroundSince the initial definition of ECD established in 2002, their use worldwide has evolved unequally, resulting in a high discard rate. A better understanding of…2015 American Transplant Congress
Opportunities in Tacrolimus Therapeutic Drug Monitoring
Department of Pharmacy, NewYork-Presbyterian Hospital, NY.
Tacrolimus requires diligent therapeutic drug monitoring (TDM) to maintain appropriate serum concentrations after transplant. To optimize efficacy & minimize toxicity frequent levels are drawn, commonly…
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