ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Effect of Induction in Renal Transplant Recipients Aged 70 and Over

    M. Lubetzky, M. Ajaimy, L. Kamal, G. DeBoccardo, E. Akalin.

    Transplantation, Montefiore Medical Center, Bronx, NY.

    While there is a significant survival advantage to transplanting patients 70 years of age and older versus staying on dialysis, it is unclear whether sensitized…
  • 2015 American Transplant Congress

    Pre-Transplant Weight Change and New-Onset Diabetes After Kidney Transplantation

    E. Huang, B. Abdalla, M. Andre, S. Bunnapradist.

    Dept of Medicine, UCLA School of Medicine, Los Angeles, CA.

    Background:We studied the association between pre-transplant weight change and new-onset diabetes after kidney transplant (NODAT).Methods:Using OPTN/UNOS data with follow-up to October, 2012, all adult (age>18…
  • 2015 American Transplant Congress

    High Tolerability With Sofosbuvir-Based Direct-Acting Antiviral Therapy in Liver Transplant Recipients With Recurrent Hepatitis C

    B. Osborne,1 A. Modi,1 M. Gautam,1 N. Murray,1 I. Gonzalez,2 J. McAfee,2 S. Gonzalez.1

    1Hepatology, Baylor Simmons Transplant Institute, Fort Worth, TX; 2Hepatology, Liver Consultants of Texas, Fort Worth, TX.

    Background: Reports on efficacy, safety, and tolerability of sofobuvir-based antiviral regimens in liver transplant recipients with recurrent hepatitis C are limited. Methods: We performed a…
  • 2015 American Transplant Congress

    Everolimus-Based Immunosuppression Is Associated With a Reduced Risk of New-Onset Malignancies After Liver Transplantation

    P. De Simone,1 P. Carrai,1 L. Coletti,1 D. Ghinolfi,1 D. Campani,2 F. Filipponi.1

    1Hepatobiliary Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy; 2Pathology, University of Pisa Medical School Hospital, Pisa, Italy.

    Background and aim: The inhibitor of the mammalian target of rapamycin (mTOR) everolimus (EVR) has shown anti-proliferative effects in experimental and clinical models. We investigated…
  • 2015 American Transplant Congress

    The Impact of Baseline and Follow-Up Social Adaptability Index Scores on Outcomes in Kidney Transplantation

    D. Taber, M. Hamedi, M. Gebregziabher, T. Srinivas, K. Chavin, L. Egede, P. Baliga.

    MUSC, Charleston, SC.

    Globally, socioeconomic status (SES) is a significant determinant of health outcomes, with the social adaptability index (SAI) representing a quantifiable and validated surrogate of SES.…
  • 2015 American Transplant Congress

    microRNA-494 Promotes Cyclosporine-Induced Nephrotoxicity and Epithelial to Mesenchymal Transition By Inhibiting PTEN

    J. Yuan,1 C. Benway,1,2 J. Bagley,1 J. Iacomini.1,2

    1Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA; 2Sackler School of Biomedical Sciences Programs in Immunology and Genetics, Tufts University School of Medicine, Boston, MA.

    Purpose: A major complication associated with cyclosporine (CsA) treatment is nephrotoxicity. MicroRNAs (miRs) have been shown to play an important role in various pathological conditions,…
  • 2015 American Transplant Congress

    Glycogen Synthase Kinase 3β Inhibition Promotes Human iTreg Differentiation and Suppressive Function

    Y. Xia, H. Zhuo, Y. Lu, L. Deng, R. Jiang, L. Zhang, L. Pu, X. Wang.

    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

    Induced regulatory T cells (iTregs) are essential to maintain immunological tolerance, immune homeostasis, and prevention of autoimmunity. Some studies suggest that glycogen synthase kinase 3β…
  • 2015 American Transplant Congress

    Long-Term Persistence of Innate Lymphoid Cells in the Gut After Intestinal Transplantation

    J. Weiner, J. Zuber, B. Shonts, S. Yang, M. Martinez, T. Kato, M. Sykes.

    Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.

    Introduction: Little is known about innate lymphoid cell (ILC) populations in the human gut, and the turnover of these cells and their subsets after transplantation…
  • 2015 American Transplant Congress

    Gene Expression Monitoring in Pediatric Heart Transplant Recipients

    C. Sutton,1 R. Butts,2 A. Burnette,3 A. Savage,2 W. Uber,1 A. Haney.1

    1Pharmacy, Medical University of South Carolina, Charleston, SC; 2Pediatric Cardiology, Medical University of South Carolina, Charleston, SC; 3Pediatric Heart Transplant, Medical University of South Carolina, Charleston, SC.

    Allomap® gene expression testing is a non-invasive screening tool approved for use in heart transplant recipients age 15 and older. Experience with Allomap® in pediatric…
  • 2015 American Transplant Congress

    Prevalence and Outcomes of Heart Transplantation in Children With Intellectual Disability

    A. Wightman,1 H. Bartlett,1 Q. Zhao,2 J. Smith.3

    1Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI; 2Biostatistics, University of Wisconsin School of Medicine and Public Health, Madison, WI; 3Pediatrics, University of Washington School of Medicine, Seattle, WA.

    Background:Heart transplantation in children with intellectual disability (ID) is a controversial issue. Previous research on this population has been limited to small case reports.Objective:To describe…
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