2015 American Transplant Congress
Toll-Like Receptor 4-Signaling Abrogates Inhibitory Effect of Calcineurin Inhibitor on B-Cells Responding to Blood Group A-Antigens
Transplant Unit, Hiroshima University, Hiroshima, Japan.
Aim: Bacterial infection following ABO-incompatible organ-transplantation is associated with refractory Ab-mediated rejection. Here, we investigated the influence of toll-like receptor (TLR)-signaling, via the binding of…2015 American Transplant Congress
Long Term Outcomes of Tocilizumab Therapy for DSA+ Antibody Mediated Rejection (ABMR) Resistant to IVIG + Rituxan (I+R) Treatment
Intro: Limited options are available for treatment of ABMR in highly-HLA sensitized patients (HS). Treatment options include I+R, PLEX+I+/- R, C5-inhibitor & bortezomib. Approximately 25%…2015 American Transplant Congress
Rejection Triggers Liver Transplant Tolerance: Involvement of Mesenchyma-Meidated Immune Control Mechanisms
Successful organ transplantation relies on lifelong immunosuppression, associated with severe side effects. Induction of tolerance is ideal but elusive in clinic. Indeed spontaneous liver transplant…2015 American Transplant Congress
Sensitization Level at Retransplant Among Non-Sensitized Pediatric Recipients of First Deceased Donor Kidney Transplants Not Affected by DR Mismatch Level
Background. Most pediatric (ped) kidney (KI) recipients (recips) received 1- or 2-DR HLA mistmached (MM) deceased donor (DD) kidneys. The degree of HLA MM between…2015 American Transplant Congress
DEPTOR Is Expressed in CD4+ T Cells and Modulates Effector Responses and Allograft Rejection
Transplant Research Program, Boston Children's Hospital, Boston, MA.
DEPTOR is an evolutionarily conserved, first-in-kind cell intrinsic factor with potential to regulate the activity of multiple intracellular signaling pathways. However, its biology in T…2015 American Transplant Congress
Prediction of Acute Antibody Mediated Rejection in Antibody Incompatible Renal Transplantation Using Machine Learning for Wide Data
The dynamic field of renal transplantation is characterised by limited access to data, the high cost of equipment and underlying complexity of immunological responses to…2015 American Transplant Congress
Efficacy of Low Dose Chemoprophylaxis for Coccidioidomycosis Infection in Liver Transplantation Recipients
Introduction:Coccidioidomycosis(CM) infection rate of 6.9% has been reported in solid organ transplantation recipients living in endemic Southwestern U.S.Aim:Assess the risk of CM infection in liver…2015 American Transplant Congress
MicroRNAs in Kidney Graft Preservation Fluid as Novel Biomarkers for Delayed Graft Function
Transplant Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
Introduction: Delayed graft function is a common complication after deceased donor kidney transplantation (KT), which affects both short and long-term outcome. Currently available biomarkers in…2015 American Transplant Congress
Early Conversion to Everolimus in De Novo Kidney Transplant Recipients: 12-Month Results from the ELEVATE Study
For the ELEVATE Study, Leiden, Netherlands.
Purpose: Long-term exposure to calcineurin inhibitors (CNIs) contributes to unfavorable long-term outcomes, including inferior renal function and premature graft loss with vascular lesions, glomerulosclerosis and…2015 American Transplant Congress
The Impact of the New Antivirals Sofosfuvir/Ledipasvir on Liver Transplantation for Hepatitis C Cirrhosis
The approval of potent antiviral therapy (AVT) with sofosfuvir/ledipasvir (sof/ldv) for hepatitis C (HCV) dramatically increased cure rates (SVR) to nearly 100%. A recent prospective…
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