Am J Transplant, Volume 5, Suppl 3 Archives - Page 66 of 170 - ATC Abstracts

2015 American Transplant Congress
Furthering the Link Between Ischemia and Immunity: Development of New Antibody Following Prolonged Delayed Graft Function
A. Gilbert,¹ E. Hall,¹ O. Timofeeva,² M. Awwad,² M. Grafals,¹ P. Weems,¹ D. Li,² S. Rosen-Bronson,² J. Moore,¹ B. Javaid,¹ M. Cooper.¹
¹Department of Surgery, MedStar Georgetown Transplant Institute, Washington, DC; ²Department of Pathology, MedStar Georgetown Transplant Institute, Washington, DC.
Introduction The purpose of this study is to examine the relationship between prolonged ischemia (delayed graft function - DGF) and the development of de novo…
2015 American Transplant Congress
Discard of Kidneys at the Margin: ECD Versus KDPI Era
S. Bae, A. Massie, D. Segev.
Johns Hopkins, Baltimore, MD.
BACKGROUND: Since 3/26/2012, the Kidney Donor Profile Index (KDPI), a percentile score reflecting donor-associated risk, has been provided with all deceased-donor kidney offers. We investigated…
2015 American Transplant Congress
New SRTR Risk-Adjustment Models for Adult Kidney Transplant Outcomes
J. Snyder,¹ N. Salkowski,¹ D. Zaun,¹ H. Xiong,¹ S. Leppke,¹ B. Thompson,¹ D. Segev,^1,2 L. Hunsicker,¹ A. Israni,¹ B. Kasiske.¹
¹Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN; ²Johns Hopkins University, Baltimore, MD.
Following a recommendation of the Consensus Conference on Transplant Program Quality and Surveillance, SRTR implemented a 3-year rolling cycle to rebuild the statistical models used…
2015 American Transplant Congress
Toll-Like Receptor 4-Signaling Abrogates Inhibitory Effect of Calcineurin Inhibitor on B-Cells Responding to Blood Group A-Antigens
H. Sakai, Y. Tanaka, H. Ohdan.
Transplant Unit, Hiroshima University, Hiroshima, Japan.
Aim: Bacterial infection following ABO-incompatible organ-transplantation is associated with refractory Ab-mediated rejection. Here, we investigated the influence of toll-like receptor (TLR)-signaling, via the binding of…
2015 American Transplant Congress
Long Term Outcomes of Tocilizumab Therapy for DSA+ Antibody Mediated Rejection (ABMR) Resistant to IVIG + Rituxan (I+R) Treatment
J. Choi,¹ A. Vo,¹ J. Kahwaji,¹ M. Haas,² N. Reinsmoen,³ D. Puliyanda,¹ A. Peng,¹ R. Villicana,¹ S. Jordan.¹
¹CTC, Cedars Sinai, Los Angeles, CA; ²Pathology, Cedars-Sinai, Los Angeles, CA; ³HLA Laboratory, Cedars-Sinai, Los Angeles, CA.
Intro: Limited options are available for treatment of ABMR in highly-HLA sensitized patients (HS). Treatment options include I+R, PLEX+I+/- R, C5-inhibitor & bortezomib. Approximately 25%…
2015 American Transplant Congress
Rejection Triggers Liver Transplant Tolerance: Involvement of Mesenchyma-Meidated Immune Control Mechanisms
M. Morita, D. Joyce, C. Miller, J. Fung, L. Lu, S. Qian.
Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Successful organ transplantation relies on lifelong immunosuppression, associated with severe side effects. Induction of tolerance is ideal but elusive in clinic. Indeed spontaneous liver transplant…
2015 American Transplant Congress
Sensitization Level at Retransplant Among Non-Sensitized Pediatric Recipients of First Deceased Donor Kidney Transplants Not Affected by DR Mismatch Level
W. Cherikh,¹ A. Wilk,¹ H. McGehee,¹ E. Brewer.²
¹United Network for Organ Sharing, Richmond, VA; ²Baylor Coll Med & Texas Children's Hosp, Houston, TX.
Background. Most pediatric (ped) kidney (KI) recipients (recips) received 1- or 2-DR HLA mistmached (MM) deceased donor (DD) kidneys. The degree of HLA MM between…
2015 American Transplant Congress
DEPTOR Is Expressed in CD4+ T Cells and Modulates Effector Responses and Allograft Rejection
J. Wedel, S. Bruneau, K. Liu, N. Kochupurakkal, M. Laplante, D. Briscoe.
Transplant Research Program, Boston Children's Hospital, Boston, MA.
DEPTOR is an evolutionarily conserved, first-in-kind cell intrinsic factor with potential to regulate the activity of multiple intracellular signaling pathways. However, its biology in T…
2015 American Transplant Congress
Prediction of Acute Antibody Mediated Rejection in Antibody Incompatible Renal Transplantation Using Machine Learning for Wide Data
T. Shaikhina,¹ N. Khovanova,¹ S. Daga,^1,3 N. Krishnan,² D. Lowe,³ D. Mitchell,¹ D. Briggs,² R. Higgins.³
¹University of Warwick, Coventry, United Kingdom; ²NHS Blood and Transplant, Birmingham, United Kingdom; ³University Hospitals Coventry and Warwickshire, Coventry, United Kingdom.
The dynamic field of renal transplantation is characterised by limited access to data, the high cost of equipment and underlying complexity of immunological responses to…
2015 American Transplant Congress
Efficacy of Low Dose Chemoprophylaxis for Coccidioidomycosis Infection in Liver Transplantation Recipients
R. El Ramahi,² S. Habib,¹ S. Rosen,³ S. Farran,³ C. Walker,³ J. Shubeilat,⁴ S. Yost,⁵ O. McCotter,⁶ M. Cassal,⁶ A. Rana,⁷ T. Boyer,¹ T. Zangeneh.²
¹Liver Research Institute, Divisions of Gastroenterology, Hepatology and Transplantation, Department of Medicine, University of Arizona, Tucson, AZ; ²Division of Infectious Disease, Department of Medicine, University of Arizona, Tucson, AZ; ³Internal Medicine Residency Program, Department of Medicine, University of Arizona, Tucson, AZ; ⁴Division of Infectious Disease, Department of Medicine, University of Massachusetts, Worcester, MA; ⁵Division of Transplantation, School of Pharmacy, University of Arizona, Tucson, AZ; ⁶Office of Border Health, Arizona Department of Health Services, Tucson, AZ; ⁷Division of Transplantation, Department of Surgery, University of Arizona, Tucson, AZ.
Introduction:Coccidioidomycosis(CM) infection rate of 6.9% has been reported in solid organ transplantation recipients living in endemic Southwestern U.S.Aim:Assess the risk of CM infection in liver…