ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Pediatric Liver Transplantation for Metabolic Diseases: Analysis of Children's Hospital of Pittsburgh (CHP) and United Network for Organ Sharing (UNOS) Databases

    A. Ganoza, B. Shneider, R. Sindhi, K. Soltys, G. Bond, G. Vockley, Q. Sun, G. Mazariegos.

    Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

    Purpose: To analyze long term patient survival outcomes after primary LTx for metabolic disease in children <21 years at CHP (1981-2014) and the multi-center UNOS…
  • 2015 American Transplant Congress

    A Single Center Study of the Implementation Costs of the New Kidney Allocation System

    C. Bostic, T. Stern, S. Niederhaus, J. Bromberg, D. Leeser.

    Transplantation, University of Maryland Medical Center, Baltimore, MD.

    Background: Changes to the Kidney Allocation System (KAS) required transplant programs to utilize resources to prepare for its implementation. A complex strategy was developed which…
  • 2015 American Transplant Congress

    Passive Administration of Antibodies to Cardiac Myosin Immediately Following Syngenic Cardiac Transplantation Result in Rejection

    M. Sharma, M. Gunasekaran, N. Benshoff, W. Liu, A. Gelman, T. Mohanakumar.

    Surgery, Washington Univ Sch of Med, St. Louis, MO.

    Introduction: Auto-immune responses to cardiac myosin, a heart specific protein has been proposed to be a target auto-antigen resulting in cardiac allograft vasculopathy following transplantation.…
  • 2015 American Transplant Congress

    Renal Tubular Dysfunction Following Donor Nephrectomy and Its Impact On Residual Kidney Function

    Z. Ahmed,1 C. Rooney,3 C. Turner,2 N. Dalton,2 N. Kessaris,1 N. Mamode.1

    1Renal and Pancreatic Transplantation, Guy's Hospital, London, United Kingdom; 2Wellchild Laboratory, St Thomas' Hospital, London, United Kingdom; 3Faculty of Medicine, King's College London, London, United Kingdom.

    Background: Recent publications have described an increasing incidence of end stage renal disease amongst kidney donors. This highlights the paucity of knowledge which exists in…
  • 2015 American Transplant Congress

    Engagement of the Vasopressin Receptor On Hepatocytes Protects Liver from Ischemia-Reperfusion Injury Via the WNT-β-Catenin-SGK1-FOXO Pathway

    X. Liu,1 T. Billiar,2 R. Tao.1

    1Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China; 2Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

    The synthetic vasopressin analogue, terlipressin, has been extensively used in the management of certain complications associated with end-stage liver diseases (ESLDs), however concerns have been…
  • 2015 American Transplant Congress

    Long-Term Efficacy and Safety of an EVR- Vs. an MMF-Based Regimen After Pediatric Kidney Transplantation (KTX): A Case-Control Study Within the CERTAIN Registry

    L. Pape,1 T. Ahlenstiel-Grunow,1 B. Hoecker,2 M. Bald,3 K. Kruppka,2 B. Toenshoff,2 L. Brunkhorst.1

    1Pediatric Nephrology, Hannover Medical School, Hannover, NDS, Germany; 2Pediatric Nephrology, University Children's Hospital, Heidelberg, BW, Germany; 3Pediatric Nephrology, Olgahospital, Stuttgart, BW, Germany.

    Background: Only short-term trials using everolimus (EVR) in children after KTX have been published. Hereby we present 4 year data on low-dose ciclosporin A (CsA),…
  • 2015 American Transplant Congress

    Allograft Class II MHC and CD40 Expression Are Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage

    T. Tanaka,1,2 H. Tsuda,1,3 N. Kohei,1,4 D. Kish,1 W. Baldwin,1 A. Valujskikh,1 R. Fairchild.1

    1Immunology, Cleveland Clinic, Cleveland, OH; 2Urology, Sapporo Medical University, Sapporo, Japan; 3Urology, Osaka University, Osaka, Japan; 4Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.

    Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
  • 2015 American Transplant Congress

    Assessment of Circulating HLA-Specific Alloreactive Memory B Cells Reveals Surreptitious Immunized Kidney Transplant Recipients at High Risk of Antibody-Mediated Rejection

    M. Lúcia,1 S. Luque,1 E. Crespo,1 J. Cruzado,1,2 E. Melilli,2 J. Martorell,3 J. Torras,1,2 S. Gil-Vernet,2 J. Grinyo,1,2 O. Bestard.1,2

    1Renal transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Catalunya, Spain; 2Experimental Nephrology Laboratory, IDIBELL, Barcelona, Catalunya, Spain; 3Histocompatibility Unit, Immunology Department, Hospital Clinic, Barcelona, Catalunya, Spain.

    Even though current bead-based multiplex techniques enable an accurate assessment of circulating HLA-specific antibodies, a more comprehensive study of the humoral alloimmune response through the…
  • 2015 American Transplant Congress

    Predicting Graft Loss in a Population of Kidney Transplant Patients Diagnosed With ABMR/TG

    J. Reeve,1 P. Halloran.1

    1Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; 2Medicine, University of Alberta, Edmonton, AB, Canada.

    ABMR is the main cause of late graft loss in kidney transplants. Our goal was to determine the variables most strongly predictive of graft loss…
  • 2015 American Transplant Congress

    Long-Term Excellent Results of ABO-Incompatible Kidney Transplantations at Multicenter Japanese Case Series

    K. Tanabe,1 H. Ishida,1 K. Masutani,2 Y. Okabe,3 M. Okumi,1 H. Kitada,2 T. Shimizu,4 H. Shirakawa.5

    1Urology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan; 2Kyushu University, Fukuoka, Japan; 3Surgery, Harasanshin Hospital, Fukuoka, Japan; 4Urology, Todachuo General Hospital, Toda, Saitama, Japan; 5Urology, Ohkubo Hospital, Shinjuku, Tokyo, Japan.

    [Background]Although kidney transplantation (KT) is the most reassuring treatment for patients with ESRD, shortage of organ donation in Japan is crucial. This issue has forced…
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