Am J Transplant, Volume 5, Suppl 3 Archives - Page 61 of 170 - ATC Abstracts

2015 American Transplant Congress
Pharmacogenetic Variation in Renal Calcineurin Inhibitor (CNI) Metabolism and the Response of Allograft-Derived Proximal Tubule Cells
N. Knops,^1,2 L. van den Heuvel,² R. Masereeuw,³ H. de Loor,⁴ E. Levtchenko,^1,2 D. Kuypers.^5,4
¹Pediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium; ²Laboratory for Pediatrics, Dept. Development & Regeneration, KU Leuven, Leuven, Belgium; ³Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, Netherlands; ⁴Laboratory of Nephrology, University Hospitals Leuven, Leuven, Belgium; ⁵Nephrology and Solid Organ Transplantation, University Hospital Leuven, Leuven, Belgium.
Background: Multiple studies have demonstrated the importance of genetic variation in CYP3A5 and ABCB1 for calcineurin inhibitor (CNI) disposition and CNI-related nephrotoxicity. Renal CNI metabolism…
2015 American Transplant Congress
Accurate Prediction of High-Resolution HLA-A, -B, -C, -DRB1 and -DQB1 Typing and Low-Resolution HLA-DQA1 Typing by Haplotype Analysis
A. Jaramillo,¹ R. Vaidya,² M. Pando,³ S. Gaitonde.⁴
¹Histocompatibility & Immunogenetics Laboratory, Gift of Hope Organ & Tissue Donor Network, Itasca, IL; ²College of Pharmacy, Roseman University of Health Sciences, South Jordan, UT; ³Department of Laboratory Medicine & Pathology, Mayo Clinic, Phoenix, AZ; ⁴Department of Pathology, University of Illinois, Chicago, IL.
Aim: Allele-specific HLA antibodies are commonly detected by Luminex single antigen bead assays in solid organ transplant recipients. However, high-resolution HLA typing for deceased donors…
2015 American Transplant Congress
Moderate Rejection Episode of Face Transplant After mTOR Conversion to Preserve Renal Function
R. Barth,¹ B. Bojovic,¹ J. Woodall,¹ M. Uluer,¹ C. Drachenberg,¹ C. Shaffer,¹ N. Kelly,¹ E. Rodriguez,² S. Bartlett.¹
¹University of Maryland School of Medicine, Baltimore; ²New York Medical University, New York City.
Face and hand vascularized composite allografts (VCA) have demonstrated durable graft survivals with conventional immunosuppression but with the appearance of renal dysfunction. Management strategies that…
2015 American Transplant Congress
Glomerulosclerosis Patterns Are Non-Uniform Throughout the KDPI Spectrum With Impact on Biopsy Evaluation of Kidneys for Transplant
M. Jendrisak,¹ K. Mulawa,¹ M. Harmon,¹ D. Cimbaluk.²
¹Gift of Hope Organ & Tissue Donor Network, Itasca, IL; ²Rush University, Chicago, IL.
Background: The kidney donor profile index (KDPI) stratifies kidney quality with direct bearing on organ allocation and utilization. Procurement biopsy is commonly performed and factored…
2015 American Transplant Congress
T-Cell Depletion Versus Interleukin-2 Antagonists in a Kidney Transplant Model of Sensitized Rhesus Macaques
C. Burghuber,^1,2 J. Kwun,¹ E. Page,¹ F. Leopardi,³ A. Gibby,¹ A. Farris,¹ N. Iwakoshi,¹ S. Knechtle.¹
¹Emory University, Atlanta, GA; ²Medical University Vienna, Vienna, Austria; ³Duke University, Durham, NC.
[Background] Sensitized patients comprise up to a third of the kidney waiting list. Preformed and newly formed alloantibodies post transplantation (TX) deteriorate graft survival, recall…
2015 American Transplant Congress
Racial Disparities in Access to Kidney Re-Transplantation in the United States
C. Garrett, R. Patzer, R. Zhang, A. Adams.
Surgery, Emory Transplant Center, Atlanta, GA.
Introduction: The number of patients with a failed kidney transplant who are being considered for re-transplantation has steadily increased over the past few years. It…
2015 American Transplant Congress
Utilization and Characteristics of Kidney Donors in the US by OPTN-Defined Increased Risk Donor Status
M. Ison,^1,2 B. Ho,² J. Leventhal,² D. Ladner.²
¹Infectious Diseases, Northwestern University, Chicago; ²Organ Transplantation, Northwestern University, Chicago.
Background: The number of candidates in need of kidney transplantation is far larger than the number of organ donors. To expand the organ pool, there…
2015 American Transplant Congress
Early Hospital Readmission and Distance from Transplant Center
E. King,¹ L. Kucirka,¹ M. McAdams-DeMarco,^1,2 A. Massie,^1,2 D. Segev.^1,2
¹Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD; ²Epidemiology, Johns Hopkins University, School of Public Health, Baltimore, MD.
Background: Early hospital readmission occurs in 31% of kidney transplant (KT) recipients and may be associated with mechanistic factors not previously captured in patient-level risk…
2015 American Transplant Congress
Incidence and Clinical Severity of Hypogammaglobulinemia (Hypo-IgG) in Highly-HLA Sensitized Patients (HS) Undergoing Desensitization (DES)
A. Vo,¹ S. Ge,² A. Petrosyan,² M. Toyoda,² J. Choi,¹ J. Kahwaji,¹ A. Peng,¹ R. Villicana,¹ S. Jordan.¹
¹Kidney Transplant, Cedars-Sinai Medical Center, LA; ²Transplant Immunology Laboratory, Cedars-Sinai Medical Center, LA, CA.
Introduction: Desensitization therapies (DES) have dramatically improved rates of transplantation among HS patients. However, antibody-reduction and B-cell/plasma cell directed therapies could have implications for humoral…
2015 American Transplant Congress
Impact of Baseline and Postoperative Isoagglutinin Titer on Clinical Outcomes in ABO-Incompatible Living Donor Kidney Transplantation
E. Shin,¹ H. Cho,¹ H. Kim,¹ C. Baeck,¹ H. Yu,¹ D. Han,² S.-K. Park.¹
¹Internal Medicine, Asan Medical Center, Seoul, Republic of Korea; ²General Surgery, Asan Medical Center, Seoul, Republic of Korea.
Background : ABO-incompatible (ABO-i) kidney transplantation (KT) has expanded in consequence of the development of desensitization protocol. However, the impact of baseline and postoperative isoagglutinin…