Am J Transplant, Volume 5, Suppl 3 Archives - Page 60 of 170 - ATC Abstracts

2015 American Transplant Congress
Quantifying Risk of ESRD in Live Kidney Donors
A. Massie, A. Muzaale, X. Luo, D. Segev.
Johns Hopkins, Baltimore.
Among live kidney donors higher overall risk of ESRD has been shown in African-Americans and men. However, individual risk of ESRD has not been quantified.METHODS:…
2015 American Transplant Congress
Correlates and Consequences of Gout Among Living Kidney Donors
N. Lam,¹ A. Garg,¹ D. Segev,² M. Schnitzler,³ H. Xiao,³ D. Axelrod,⁴ J. Tuttle-Newhall,³ D. Brennan,⁵ B. Kasiske,⁶ K. Lentine.³
¹Western Uni., London, Canada; ²John Hopkins Uni., Baltimore; ³Saint Louis Uni., St. Louis; ⁴Dartmouth Hitchcock Medical Center, Hanover; ⁵Washington Uni., St. Louis; ⁶Uni. of Minnesota, Minneapolis.
Background: Currently, the demographic correlates and consequences of gout in living kidney donors are understudied.Methods: We examined a novel database that linked national U.S. identifiers…
2015 American Transplant Congress
Comparison of the Clinical Outcome and Surgical Invasiveness for Living Donor Nephrectomy Between Conventional Laparoscopic Surgery and Single-Port Surgery
M. Saito, S. Satoh, R. Yamamoto, H. Tsuruta, S. Akihama, T. Inoue, S. Narita, N. Tsuchiya, T. Habuchi.
Urology, Akita University Graduate School of Medicine, Akita, Japan.
INTRODUCTION AND OBJECTIVES:Single-port surgery (SPS) for living donor nephrectomy (LDN) is challenging. Whether SPS is less invasive compared to conventional laparoscopic surgery (CLS) using several…
2015 American Transplant Congress
Extracorporeal Life Support: A Rescue Therapy in a Lung Transplantation Program
P. Mohite, D. Gacia-Saez, B. Zych, N. Patil, M. Zeriouh, A. Koch, A.-F. Popov, A. Reed, M. Carby, F. DeRobertis, T. Bahrami, M. Amrani, S. Penn, S. Silver, S. Soresi, A. Simon.
Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, London, Middlesex, United Kingdom.
Purpose: Extracorporeal Life Support (ECLS) is increasingly used as a bridge to lung transplantation (LTx) as well as in the management of severe primary graft…
2015 American Transplant Congress
Change in Physical Function Following Kidney Transplantation
E. Lorenz, A. Cheville, B. Kotajarvi, F. Cosio, N. LeBrasseur.
Mayo Clinic, Rochester, MN.
Introduction: Improved physical function is associated with increased survival in the general population. Little is known about whether physical function improves following kidney transplant. The…
2015 American Transplant Congress
Differences in Reactivity of HLA-Specific Antibodies May Be Explained By Differences in Their Affinities for Selected Epitopes on HLA Proteins
S. Daga,^1,2 D. Lowe,⁶ R. Buchli,⁵ J. Collard,⁵ A. Mulder,⁸ C. McMurtrey,^4,5 H. Moyse,⁷ N. Evans,⁷ N. Krishnan,² W. Hildebrand,^4,5 F. Claas,⁸ D. Briggs,³ D. Zehnder,^1,2 D. Mitchell,¹ R. Higgins.^1,2
¹Clinical Sciences Research Laboratories, University of Warwick, Coventry, United Kingdom; ²Renal Unit, University Hospital, Coventry and Warwickshire NHS Trust, Coventry, United Kingdom; ³Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Birmingham, United Kingdom; ⁴University of Oklahoma Health Science Center, Oklahoma City; ⁵Pure Protein LLC, Oklahoma City; ⁶Department of Histocompatibility and Immunogenetics, Royal Liverpool University Hospital, Liverpool, United Kingdom; ⁷School of Engineering, University of Warwick, Coventry, United Kingdom; ⁸Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
Affinity of IgG immunoglobulins for antigen varies and matures within the evolution of immune responses. Affinity is likely to be different for different epitope-antibody interactions…
2015 American Transplant Congress
Gene Expression of Kidney Biopsies Reveals Common Mechanisms of Rejection and a Cluster of Co-Expressed Genes Predictive of Long-term Outcomes
B. Modena,¹ S. Kurian,¹ J. Friedewald,² F. Harrison,¹ T. Gelbart,¹ S. Head,¹ M. Abecassis,² D. Salomon.¹
¹The Scripps Research Institute, La Jolla; ²Northwestern University, Chicago.
Purpose: Acute rejection (AR) still affects 8-14% of kidney transplants and rates of 10-year graft loss remain unchanged in part due to chronic rejection (CR).…
2015 American Transplant Congress
The Role of Skin-Specific Immunobiology and Major Histocompatibility Complex Sharing in Vascularized Composite Allograft Tolerance
D. Leonard, K. Shanmugarajah, H. Powell, A. Albritton, C. Mallard, D. Sachs, C. Cetrulo, Jr., J. Kurtz.
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA.
Background: We have developed a reproducible model for induction of tolerance of all components of VCAs across haploidentical MHC barriers in miniature swine. The purpose…
2015 American Transplant Congress
Immunomodulatory Strategies Directed Towards Tolerance of Vascularized Composite Allografts
M. Madariaga, K. Shanmugarajah, S. Michel, V. Villani, G. La Muraglia II, R. Torabi, D. Leonard, M. Randolph, R. Colvin, K. Yamada, J. Madsen, C. Cetrulo, Jr., D. Sachs.
Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Background: Achieving tolerance of vascularized composite allografts (VCAs) would improve the risk-to-benefit ratio in patients who undergo this life-enhancing transplant. Kidney co-transplantation along with a…
2015 American Transplant Congress
Tissue Engineering Human Kidneys for Costimulation Blockade
L. Brasile,¹ N. Henry,¹ A. Meyer,¹ B. Stubenitsky.²
¹BREONICS, Inc., Watervliet, NY; ²Surgery, University of Utrecht, Utrecht, Netherlands.
Methods for preserving organs have employed hypothermic conditions. At these temperatures metabolism is 4% of normal. Tissue engineering of organs cannot be done without significant…