Am J Transplant, Volume 5, Suppl 3 Archives - Page 50 of 170 - ATC Abstracts

2015 American Transplant Congress
Variants Associated With Tacrolimus Troughs in European American Kidney Transplant Recipients: A Genome Wide Association Study
P. Jacobson,¹ M. Miller,² D. Schladt,³ A. Israni,³ K. Sanghavi,¹ C. Dorr,³ R. Remmel,¹ W. Guan,⁴ A. Matas,⁵ W. Oetting.¹
¹College of Pharmacy, University of MN, Minneapolis, MN; ²Department of Psychology, University of MN, Minneapolis, MN; ³Department of Nephrology and Chronic Disease Research Group, Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; ⁴Department of Biostatistics, University of MN, Minneapolis, MN; ⁵Department of Surgery, University of MN, Minneapolis, MN.
Tacrolimus (tac) is dependent on CYP3A4/5 for metabolism. Variability in the metabolism is influenced by CYP3A5*3 alleles. This variant and clinical factors explain around 50%…
2015 American Transplant Congress
Molecular Testing for Microcirculation Injury Enhances the Assessment of Antibody-Mediated Rejection in Human Cardiac Allograft Biopsies
B. Afzali,¹ E. Chapman,¹ B. Adam,¹ F. Riesgo Gil,² D. Kim,² L. Hidalgo,¹ P. Campbell,¹ B. Sis,¹ M. Mengel.¹
¹Dept. of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ²Div. of Cardiology, University of Alberta, Edmonton, AB, Canada.
BACKGROUND: Despite continuous attempts to refine diagnostic consensus, accurate assessment of Antibody-mediated rejection (AMR) is an ongoing unmet need. The microcirculation represents the primary target…
2015 American Transplant Congress
Characteristics of IgGs Produced in Neu5Gc and α1-3 Gal Double Knock-Out Pigs
A. Salama,^1,2 S. Conchon,¹ A. Perota,³ B. Martinet,¹ J.-P. Judor,¹ G. Evanno,¹ S. Le-Bas Bernardet,¹ L. Le Berre,¹ J. Hervouet,¹ D. Minault,¹ J.-P. Concordet,⁴ E. Dugast,¹ B. Vanhove,¹ J. Abadie,⁵ N. Gaide,⁵ I. Lagutina,³ R. Duchi,³ G. Lazzari,³ D. Sachs,⁶ O. Gauthier,⁷ S. Brouard,¹ E. Cozzi,⁸ G. Blancho,¹ H. Perreault,⁹ J.-M. Bach,¹⁰ C. Galli,^3,11 J.-P. Soulillou.¹
¹INSERM UMR 1064, ITUN, CHU de Nantes, Nantes University, Nantes, France; ²Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France; ³Avantea, Laboratory of Reproductive Technologies, Cremona, Italy; ⁴INSERM U565, CNRS UMR7196, MNHN USM503, Paris, France; ⁵AMaROC, ONIRIS, Nantes, France; ⁶Massachusetts General Hospital, Transplantation Biology Research Center, Boston, MA; ⁷Centre de Recherche et d'Investigation Préclinique, ONIRIS, Nantes, France; ⁸Padua General Hospital and Consortium for Research in Organ Transplantation, Padua, Italy; ⁹Chemistry Department, University of Manitoba, Winnipeg, Canada; ¹⁰IECM, EA4644 University/ONIRIS USC1383 INRA, ONIRIS, Nantes, France; ¹¹Dept. of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
Xenotransplantation offers a large number of potential applications, including solid organs, pancreatic islets, acellular tissues such as heart valves and skin grafts, and new bioreagents…
2015 American Transplant Congress
Does Pulmonary Rehabilitation Impact Frailty?
C. Kennedy,¹ P. Novotny,² N. LeBrasseur,³ R. Wise,⁴ F. Sciurba,⁵ R. Benzo.¹
¹Pulmonary and Critical Care, Mayo Clinic, Rochester, MN; ²Health Sciences Research-Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN; ³Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN; ⁴Pulmonary and Critical Care, Johns Hopkins, Baltimore, MD; ⁵Pulmonary, Allergy and Critical Care, University of Pittsburgh, Pittsburgh, PA.
Purpose: Frailty is an emerging risk factor for morbidity and mortality in advanced lung disease and lung transplantation. Interventions to reduce frailty in this population…
2015 American Transplant Congress
Activation and Sequestration of Platelets During Xenogeneic GalTKO.hCD46 Pig Lung Perfusion Is Primarily Mediated By GPIb, GPIIb/IIIa, and VWF
L. Burdorf,¹ A. Riner,¹ A. Shah,¹ E. Schwartz,¹ K. Quinn,¹ E. Kang,¹ E. Sievert,¹ E. Rybak,¹ D. Harris,¹ T. Zhang,¹ D. Parsell,¹ X. Cheng,¹ G. Braileanu,¹ S. De Meyer,² I. Salles,² H. Deckmyn,² C. Phelps,³ D. Ayares,³ R. Pierson III,¹ A. Azimzadeh.¹
¹Surgery, University of Maryland, Baltimore, MD; ²Laboratory for Thrombosis Research, IRF-Ls, Kulak KU Leuven, Leuven, Belgium; ³Revivicor, Inc., Blacksburg, VA.
Background: Xenogeneic pig lung perfusion with human blood leads to the initiation of rejection mechanisms that are associated with the immediate sequestration of circulating platelets.…
2015 American Transplant Congress
Estimated Prevalence of HIV in Kidney Transplant Candidates
A. Shaffer, X. Luo, L. Kucirka, A. Cash, A. Massie, C. Durand, D. Segev.
Surgery, Johns Hopkins University, Baltimore, MD.
The passage of the HOPE Act in November 2013 mandated research into HIV+ to HIV+ organ transplantation. To date, the prevalence of HIV in the…
2015 American Transplant Congress
Causes of Poor Renal Function of Kidney Transplants from Uncontrolled Donation After Cardiac Death Donors (UDCDD)
M. Molina, E. González, E. Gutiérrez, E. Morales, E. Hernández, A. Sevillano, N. Polanco, J. Cabrera, M. Praga, A. Andres.
Nephrology, Hospital 12 de Octubre, Madrid, Spain.
INTRODUCTION: Kidneys grafts from UDCDD have higher ischemia injury. It develops in higher primary non function, lower graft survival and worst renal function compared to…
2015 American Transplant Congress
Incidence and Risk Factors for Emergency Department Visits Following Kidney Transplantation
N. Elfadawy,^1,2 E. Poggio,¹ D. Goldfarb,¹ L. Buccini,¹ S. Flechner,¹ J. Schold.¹
¹Cleveland Clinic, Cleveland, OH; ²Medical Research Institute - Alexandria University, Alexandria, Egypt.
Emergency department (ED) visits contribute substantially to healthcare costs, transition-of-care errors and add to patient burden. There are approximately 135 million ED visits annually in…
2015 American Transplant Congress
Implementation of Pre-Transplant Infectious Disease Risk Assessment: Sustained Success With Rapid-Cycle Improvement
L. Danziger-Isakov, S. Blum, D. Dahale, B. Morrow, R. Rengering, D. Schoborg, S. Stark, E. Wells, A. Lorts, U. Kotagal, J. Bucuvalas.
Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Pre-transplant infectious disease risk assessment can identify and mitigate potential risk for transplant candidates to improve post-transplant outcomes. We aimed to improve pre-transplant ID risk…
2015 American Transplant Congress
The Use of Bortezomib for Desensitization in ABO Incompatible and Positive Crossmatch Kidney Transplant
J. Benken,¹ S. Akkina,² E. Benedetti.³
¹Pharmacy Practice, Univ. of IL-Chicago, Chicago, IL; ²Dept. of Medicine, Nephrology, Univ. of IL-Chicago, Chicago, IL; ³Dept. of Surgery, Univ. of IL-Chicago, Chicago, IL.
Introduction:ABO incompatible (ABOi) and positive crossmatch (PXM) living donor kidney transplantation is a life-saving alternative to dialysis. A variety of protocols exist utilizing plasmapheresis (PP)…