Am J Transplant, Volume 5, Suppl 3 Archives - Page 46 of 170 - ATC Abstracts

2015 American Transplant Congress
Small RNA Sequencing-Enabled Discovery of Circulating Extracellular MicroRNAs as Noninvasive Biomarkers of Liver Allograft Status
H. Yang,¹ T. Muthukumar,¹ K. Akat,² D. Briskin,² T. Tuschl,² M. Suthanthiran.¹
¹Weill Cornell Medical Center, New York; ²Rockefeller University, New York.
MicroRNAs are ideal candidates as blood-based biomarkers. Comprehensive profiling of microRNAs is challenging. We overcame the existing challenges by developing robust protocols for isolation of…
2015 American Transplant Congress
Patients With Severe and Morbid Obesity Benefit from Deceased Donor Kidney Transplant
A. Nishio Lucar,¹ J. Ma,² G. Vranic,¹ D. Keith.¹
¹Medicine, University of Virginia, Charlottesville, VA; ²Biostatistics, University of Virginia, Charlottesville, VA.
More than one in three Americans are obese yet obesity is considered a relative and sometimes absolute contraindication to kidney transplant. Previous studies suggest that…
2015 American Transplant Congress
Reasons for Match Offer Refusals and Efforts to Reduce Them in the OPTN/UNOS Kidney Paired Donation Pilot Program (KPDPP)
R. Leishman,¹ D. Stewart,¹ A. Kucheryavaya,¹ L. Robbins Callahan,¹ T. Sandholm,² M. Aeder.³
¹UNOS, Richmond, VA; ²Carnegie Mellon Univ, Pittsburgh, PA; ³Univ Hosp Case Med Ctr, Cleveland, OH.
Background: The OPTN/UNOS KPDPP has been finding 2-way, 3-way, and chain exchanges since Oct 2010. Though the number of pairs entered, matches found, and transplants…
2015 American Transplant Congress
Changes in Acceptances Patterns Under Share 35
K. Washburn, E. Edwards, A. Harper.
University of Texas HSC, San Antonio, TX; UNOS, Richmond, VA.
The Share 35 policy was implemented June 2013 with intent of directing to livers to the sickest patients with the highest mortality and presumably shortest…
2015 American Transplant Congress
Closing the Knowledge Gap: The Successful Launch of an Interactive Website Dedicated to Information on Living Kidney Donor Transplantation
D. Slaats,¹ W. Zuidema,¹ J. van de Wetering,¹ D. Hesselink,¹ T. Terkivatan,² M. Betjes.¹
¹Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands; ²Surgery, Division of Transplant Surgery, Erasmus MC, Rotterdam, Netherlands.
Introduction. The internet is increasingly used to find reliable information about living kidney donation (LKD) and transplantation (LKT). Therefore, an easily accessible, interactive website was…
2015 American Transplant Congress
MicroRNA (miR) 144 Dysregulates TGFβ Signaling Cascade and Contributes to Development of BOS Following Human Lung Transplantation
Z. Xu,¹ S. Ramachandran,¹ D. Nayak,¹ M. Gunasekaran,¹ E. Trulock,¹ R. Hachem,¹ D. Kreisel,¹ T. Mohanakumar.¹
¹Surgery, Washington Univ Sch Med, St. Louis, MO; ²Medicine, Washington Univ Sch Med, St. Louis, MO.
Background: Bronchiolitis Obliterans Syndrome (BOS) is characterized by a fibroproliferative cascade that is not amenable to current treatment regimens and remains the major impediment for…
2015 American Transplant Congress
Immunological Aspects of Iron Overload in Heart and Kidney Transplantation
T. Resch,¹ S. Ebner,¹ P. Ritschl,¹ M. Ashraf,¹ C. Fabritius,¹ A. Brunner,² V. Nguyen,¹ J. Günther,¹ J. Pratschke,³ K. Kotsch.¹
¹Department of Surgery, Medical University Innsbruck, Innsbruck, Austria; ²Department of Pathology, Medical University Innsbruck, Innsbruck, Austria; ³Department of Surgery, Charité, Berlin, Germany.
Background: Clinical data suggest that iron (Fe) overload deleteriously affects graft survival after heart (HTX) and kidney transplantation (KTX) but possible immunologic mechanisms underlying this…
2015 American Transplant Congress
Incidence and Outcomes of Polyomavirus Infection in 639 Kidney Transplant Recipients: Are High Immunological Risk Characteristics More Relevant Than Specific Induction Or Maintenance Immunosuppressive Regimens?
E. Favi,¹ L. Harris,² J. Worsfold,² R. Cacciola,¹ C. Puliatti,¹ C. Sammartino,¹ R. Sivaprakasam.¹
¹Transplantation, Royal London Hospital, London, United Kingdom; ²Barts and The London School of Medicine and Dentistry, London, United Kingdom.
Introduction. Polyomavirus-associated nephropathy (PVAN) is now recognized as an important cause of graft dysfunction and early kidney transplant loss. Over-immunosuppression is the main risk factor…
2015 American Transplant Congress
A Clinical Signature Surrogate of Histological Lesions to Avoid Unnecessary One Year Surveillance Biopsy After Renal Transplantation
E. Dantan, K. Renaudin, S. Brouard, A. Huneau, C. Paul, M. Giral.
Biostatitics, Nantes University, Nantes, France; Anatomo Pathology, University Hospital, Nantes, France; Immunology, Inserm UMR1064, Nantes, France; Biostatistics, Nantes University, Nantes, France; Immunology, Inserm UMR1064, Nantes, France; Nephrology, University Hospital, Nantes, France.
Introduction:Surveillance biopsy remains debated after renal transplantation since the histological diagnostic do not lead to clear therapeutic recommendations. The main objective for this study was…
2015 American Transplant Congress
An Investigation of 12 Cases of Membranous Nephropathy of the Donor Origin Accidentally Detected by 0-h Renal Biopsy During Kidney Transplantation
K. Unagami,¹ D. Toki,¹ M. Okumi,¹ H. Ishigooka,¹ K. Tsujimura,¹ T. Kanzawa,¹ K. Omoto,¹ H. Ishida,¹ K. Nitta,² K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan; ²Nephrology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.
Membranous Nephropathy (MN) is a type of glomerulonephritis characterized by thickening of the glomerular basement membrane with immunoglobulin deposition. Proteinuria is a primary symptom, and…