ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    2-Year Results on Renal Function and Safety for Everolimus plus Reduced-Exposure Calcineurin Inhibitor in Living Donor Kidney Transplant Recipients

    T. Yagisawa,1 N. Ishikawa,1 N. Goto,2 I. Nakajima,3 O. Kamisawa,4 S. Fuchinoue.3

    1Division of Renal and Transplantation, Jichi Medical University, Shimotsuke, Japan; 2Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; 3Surgery, Kidney Center, Tokyo Women's University, Tokyo, Japan; 4Medical Division, Novartis Pharma K.K., Tokyo, Japan.

    Purpose: The long-term effects of everolimus (EVR) with reduced cyclosporine (rCsA) exposure over 24 months on renal function and safety (viral infection) were assessed in…
  • 2015 American Transplant Congress

    Intra-Lymphocyte Concentrations of Mycophenolic Acid Correlate With the Incidence of Early Graft Rejection in Renal Transplant Recipients

    Z. Md Dom,2 J. Coller,2 R. Carroll,3 A. Somogyi,2 B. Sallustio.1

    1Clinical Pharmacology, The Queen Elizabeth Hospital, Adelaide, Australia; 2Discipline of Pharmacology, Univeristy of Adelaide, Adelaide, Australia; 3Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, Australia.

    Introduction: Although routine therapeutic drug monitoring of mycophenolic acid (MPA) concentrations in plasma has been recommended to individualize MPA doses in transplant recipients, little is…
  • 2015 American Transplant Congress

    Reassessing Tubulitis and Interstitial Infiltrate: Creating a New Probabilistic Definition of TCMR

    P. Halloran, I. Salazar, M. Lopez, J. Chang.

    Alberta Transplant Applied Genomics Centre, Edmonton, Canada.

    Conventional diagnosis of T cell-mediated rejection (TCMR) in kidney transplant biopsies relies on interstitial inflammation (i-lesions), tubulitis (t-lesions), vasculitis (v-lesions) and experience-derived interpretation rules. The…
  • 2015 American Transplant Congress

    Long-Term Survival Outcomes of Liver Transplantation for Klatskin Tumour: A Comparative Study With Radical Resection Surgery

    A. Hu, X. Zhu, X. He.

    Department of general Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    Background and aim: Besides radical resection (RR), Liver transplantation (LT) is another suggested surgical modality for hilar cholangiocarcinoma (Klatskin tumour, KT) especially for patients whose…
  • 2015 American Transplant Congress

    The Epidemiology of Surgical Site Infections Among Pediatric Liver Transplant Recipients

    D. Banach,1 A. Munoz-Abraham,2 L. Dembry,1 M. Rodriguez-Davalos.2

    1Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT; 2Yale-New Haven Transplantation Center, Yale-New Haven Hospital, New Haven, CT.

    Background: Surgical site infections (SSI) are a significant cause of morbidity among adult liver transplant (LT) recipients. Data on SSI epidemiology and SSI-associated outcomes among…
  • 2015 American Transplant Congress

    Vitamin D Deficiency and Hypertension in Pediatric Kidney Transplant Patients: Could We Be Doing More?

    K. Twombley,2 O. Moussa.1

    1Pathology, Medical University of South Carolina, Charleston; 2Pediatrics, Medical University of South Carolina, Charleston, SC.

    Introduction and Objective: 50-80% of pediatric kidney transplant patients have hypertension (HTN). HTN is a known risk factor for decreased allograft function and survival in…
  • 2015 American Transplant Congress

    Dermatology Is an Essential Part of Transplant Care: Report of a Two-Year Experience from a Transplant Dermatology Center

    E. Pritchett,1 B. Miller,1 A. Colasacco,1 G. Malat,2 A. Doyle,2 S. Guy,3 C. Cusack,1 C. Chung,1 M. Abdelmalek.1

    1Department of Dermatology, Drexel University College of Medicine, Philadelphia; 2Departent of Medicine, Drexel University College of Medicine, Philadelphia; 3Department of Surgery, Drexel University College of Medicine, Philadelphia.

    Background: It is well-documented that patients who have undergone organ transplantation have a higher incidence of new skin cancers and that this risk is magnified…
  • 2015 American Transplant Congress

    Correlation of Longitudinal Gene-Expression Profiling Score to Cytomegalovirus Infection: Results from the Outcomes AlloMap® Registry

    M. Kanwar,1 J. Yee,2 G. Ewald,3 S. Murali,1 J. Teuteberg.4

    1Allegheny Singer Research Institute, Pittsburgh, PA; 2CareDx, Inc., Brisbane, CA; 3Washington University, St. Louis, MO; 4University of Pittsburgh Medical Center, Pittsburgh, PA.

    Purpose: Cytomegalovirus (CMV) infection has been implicated in the pathogenesis of allograft rejection, which is reflected by high gene-expression profiling (GEP) scores. In the IMAGE…
  • 2015 American Transplant Congress

    Safety and Outcome of Ganciclovir-Resistant CMV Treated With Foscarnet: A Single Center Retrospective Study

    B. Pierce,4 C. Richardson,4 K. Cunningham,4 C. D'Agostino,4 C. Tseng,4 J. Brown,4 C. O'Brien,4 B. Ho,1,3,5 M. Ison.1,2,3

    1Department of Medicine, Northwestern Medicine, Chicago, IL; 2Division of Infectious Diseases, Northwestern Medicine, Chicago, IL; 3Division of Organ Transplantation, Northwestern Medicine, Chicago, IL; 4Pharmacy, Northwestern Medicine, Chicago, IL; 5Transplant Nephrology, Northwestern Medicine, Chicago, IL.

    Background: Infection with cytomegalovirus (CMV) is an important cause of morbidity and mortality following solid organ transplantation (SOT). Resistance can rarely develop via mutations in…
  • 2015 American Transplant Congress

    A Cross-Organ Tissue Gene Expression Immune Signature Predates Chronicity

    Y. Ng, O. Bestard, T. Sigdel, S.-C. Hsieh, T. Tran, M. Sarwal.

    Transplantation Surgery, UC San Francisco, San Francisco, CA.

    Purpose Meta-analysis of 796 microarrays led to the discovery of 11 over-expressed genes (BASP1, CD6, CXCL9, CXCL10, INPP5D, ISG20, LCK, NKG7, PSMB9, RUNX3, and TAP1)…
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