2015 American Transplant Congress
Absence of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and 2 Modifies Adaptive Immune Responses
Background:The NOD family of intracellular pattern recognition receptors (PRRs) plays a key role in immune responses to microbial and danger signals. This family of proteins…2015 American Transplant Congress
Risk Factors Influencing Mammography Screening During Kidney Transplant Evaluation
Transplant Institute, University Hospitals & Case Western Reserve University, Cleveland, OH.
INTRO:Transplant centers typically require mammography (MMG) for women ≥ 40 as part of the evaluation process. The American Cancer Society recommends annual mammograms for the…2015 American Transplant Congress
Attenuating Racial Disparities in Kidney Transplantation Through the Use of Potent Immunosuppression Regimens
Medical University of South Carolina, Charleston, SC.
African-American (AA) kidney transplant (KTX) recipients have higher rates of graft loss, which may be partially attributed to higher immunologic risk. The aim of this…2015 American Transplant Congress
The Liver X Receptor Alpha (LXRα) Knockout Protect Liver Against Ischemia-Reperfusin Injury in Mice
Background: Liver X Receptor Alpha (LXRα) is a transcription factor crucial for cholesterol, fatty acid, and glucose homeostasis. We hypothesize that LXRαKO may promote hepatocellular…2015 American Transplant Congress
The Effects of Periostin on Renal Fibrosis After Ischemia-Reperfusion Injury Via p38 MAPK Pathway
Ischemia-reperfusion injury during the transplantation procedure is associated with poor long-term allograft outcomes, such as rejection and fibrosis. Periostin, a matricellular protein, has been reported…2015 American Transplant Congress
Type III Phosphodiesterase (PDE3) Inhibitor Improves Survival Rate After Ischemia Reperfusion Injury of the Liver in Rats
BackgroundPDE3 inhibitor (Cilostazol) has long been used as a potent inhibitor of platelet aggregation and thrombosis. Recently, there have been a report on the protective…2015 American Transplant Congress
Influence of CYP3A5 and ABCB1 Genotypes on Pharmacokinetics of Immediate and Prolonged Release Tacrolimus Preparations
Background. Tacrolimus is available in two formulations, immediate-release, (Prograf®) and prolonged -release formulation of tacrolimus (Advagraf®). Tacrolimus has a narrow therapeutic index with wide variation…2015 American Transplant Congress
Calcineurin Inhibitors (CNI) Minimization Associated With Mammalian Target of Rapamycin Inhibitors (i-mTOR) to Improve Renal Function in Renal Grafts from Uncontrolled Donation After Cardiac Death Donors (UDCDD)
INTRODUCTION: Ischemia injury in kidneys grafts from UDCDD could produce a poor renal function. Minimized blood levels of CNI associated with i-mTOR therapy could avoid…2015 American Transplant Congress
Significance of an Isolated Elevated PRA in Renal Transplantation
Houston Methodist Hospital, Houston, TX.
Transplant centers have traditionally discerned a patient's immunologic risk based on peak panel reactive antibody (PRA) levels. However, in a given patient, pre-transplant PRA may…2015 American Transplant Congress
Alpha-Fetoprotein as a Modifier of Anatomic Criteria for Transplantation of HCC Patients
Background:The current listing criteria (Milan, UCSF) for Orthotropic Liver Transplants (OLT) in hepatocellular carcinoma (HCC) patients emphasize the anatomic features of the tumor such as…
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