Am J Transplant, Volume 5, Suppl 3 Archives - Page 43 of 170 - ATC Abstracts

2015 American Transplant Congress
The Preservation Technique Modulates the Immunological Milieu in Lung Transplantation and Affects the Pro-/ Anti-Inflammatory Balance
M. Seyda,¹ B. Wiegmann,³ B. Mueller,² C. Neudoerfl,¹ A. Akhdar,¹ K. Daemen,¹ A. Haverich,^3,4 G. Warnecke,^3,4 C. Falk.^3,5
¹Inst. of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; ²MorphoSys, Munich, Germany; ³Cardiothoracic, Transplantation and Vascular Surgery, Hanover Medical School, Hanover, Germany; ⁴German Center for Lung Research, Gießen, Germany; ⁵German Center for Infection Research, Braunschweig, Germany.
Little is known regarding the influence of different preservation techniques (i.e. cold static storage with Perfadex® or Celsior® solution) on the immunological milieu, especially lung-resident…
2015 American Transplant Congress
Change in Frailty Status Over Time Among In-Center Hemodialysis ESRD Patients in the ACTIVE/ ADIPOSE Study
B. Tao, J. Gander, N. Kutner, S. Pastan, R. Zhang, R. Patzer.
Emory University, Atlanta, GA.
Introduction: Frailty among End Stage Renal Disease (ESRD) is associated with poor health outcomes, including delayed graft function and hospitalization following transplantation. Although frailty is…
2015 American Transplant Congress
Highly Accurate High-Resolution HLA Imputation Using Dense Genotyping Data
B. Keating,¹ Y. Li,¹ T. Guettouche,² K. Olthoff,¹ A. Shaked.¹
¹Surgery (Division of Transplantation), University of Pennsylvania, Philadelphia, PA; ²Genetics, Children's Hospital of Philadelphia, Philadelphia, PA.
HLA similarity between donors (D) and recipients (R) of solid organ transplantation (SOT) plays a central role in determining the risk of rejection or graft-versus-host…
2015 American Transplant Congress
Differentially Expressed Genes in Immunosuppressed Kidney Transplant Recipients
C. Dorr,¹ B. Wu,² W. Guan,² A. Muthusamy,¹ K. Sanghavi,³ P. Jacobson,³ W. Oetting,³ D. Schladt,¹ R. Remmel,³ J. Maltzman,⁵ A. Matas,⁴ For DeKAF Genomics Investigators,¹ A. Israni.¹
¹Medicine, MMRF, HCMC, Minneapolis, MN; ²Biostatistics, University of MN, Minneapolis, MN; ³Pharmacy, University of MN, Minneapolis, MN; ⁴Surgery, University of MN, Minneapolis, MN; ⁵Medicine, University of PA, Philadelphia, PA.
Introduction: In our effort to personalize immunosuppressive therapies we performed RNA sequencing (RNAseq) to identify differentially expressed genes (DEGs) after kidney transplant (tx) and the…
2015 American Transplant Congress
Identification of Genetic Variants Associated With Variation of Tacrolimus Levels in African Americans Using GWAS
W. Oetting,¹ D. Schladt,² W. Guan,¹ A. Israni,² R. Remmel,¹ C. Dorr,² K. Sanghavi,¹ R. Mannon,³ B. Herrera,⁴ A. Matas,¹ D. Salomon,⁵ P. Kwok,⁴ P. Jacobson,¹ for DeKAF Genomics.¹
¹Univ. of Minnesota, Minneapolis; ²Minneapolis Medical Research Foundation, Minneapolis; ³Univ. of Alabama, Birmingham; ⁴Univ. of California, San Francisco; ⁵Scripps Research Center, La Jolla.
African American kidney transplant recipients (AA) have a higher incidence of allograft failure when compared to Caucasians. We have previously reported that tacrolimus troughs (TT)…
2015 American Transplant Congress
Immunological Evaluation of Acellular Extracellular Matrix Upon Transplantation
M. Ketaki,¹ P. Pradeep,¹ N. Nikhil,¹ G. Dellgren,³ H. Suchitra, M. Olausson.²
¹Laboratory for Transplantation Regenerative Medicine, Surgery, Gothenburg University, Gothenburg, Sweden; ²Department of Surgery, SU/Sahlgrenska University Hospital, SE 41345, Gothenburg, Sweden; ³Cardiothoracic Surgery, Transplant Institute, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.
Background : To mitigate the scanty supply of donor organs, porcine tissues can be utilized since, it embrace the potential to accomplish the task of…
2015 American Transplant Congress
Microchimerism-Tolerance “Missing Link”: Exosome Acquisition by Host Dendritic Cells
W. Bracamonte-Baran, E. Jankowska-Gan, Y. Zhou, W. Burlingham.
Surgery, University of Wisconsin, Madison, WI.
Background: widespread maternal microchimerism (MMc) in mice is associated with development of immune regulation, which can be used to predict transplantation tolerance. We recently showed…
2015 American Transplant Congress
Donor Dendritic Cells – Potential New Therapeutic Target in Transplantation
T. Ueno,^1,2,3 M. Yeung,¹ M. McGrath,¹ H. Iwamoto,³ Y. Nakamura,³ O. Konnno,³ Y. Kihara,³ T. Yokoyama,³ S. Ono,³ T. Ikeda,³ S. Kawachi,³ B. Ibrahim,¹ A. Chandraker.¹
¹Renal, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Transplant Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan.
Background: It is clear that T cells play a central role in the process of allograft rejection. However, donor dendritic cells (dDC) are the most…
2015 American Transplant Congress
Educating the Less Prepared: Transplant Knowledge and Decision-Making Differences by Race at Onset of Evaluation
A. Waterman,¹ J. Peipert,¹ S. Brann,² C. Kynard-Amerson,¹ M. Robbins,³ A. Paiva,³ A. Gaber.²
¹David Geffen School of Medicine, UCLA, Los Angeles, CA; ²Methodist J.C. Walter Jr. Transplant Center, Houston, TX; ³University of Rhode Island, Kingston, RI.
Racial minorities have higher rates of kidney failure than Whites but are less likely to receive kidney transplants. This study described each race/ethnic groups' level…
2015 American Transplant Congress
Validating Outcomes Reported to the Organ Procurement and Transplantation Network for Deceased Donor Kidney Recipients
V. Potluri,¹ C. Parikh,² I. Hall,² J. Ficek,² M. Doshi,³ I. Butrymowicz,² F. Weng,⁴ B. Schröppel,⁵ H. Thiessen-Philbrook,⁶ P. Reese.⁷
¹Lankenau Hospital, Philadelphia; ²Yale University School of Medicine, New Haven; ³Wayne State University, Detroit; ⁴Barnabas Health, Livingston, NJ; ⁵University Hospital, Ulm, Germany; ⁶Western University, Ontario, Canada; ⁷University of Pennsylvania, Philadelphia.
Data reported to the Organ Procurement and Transplantation Network (OPTN) is used in kidney transplant research, quality metrics and in policy development, but the accuracy…