Am J Transplant, Volume 5, Suppl 3 Archives - Page 43 of 170 - ATC Abstracts

2015 American Transplant Congress
Anti-CD122 + Costimulation Blockade Prolongs Allograft Survival
D. Mathews,¹ L. Higginbotham,¹ Y. Dong,¹ C. Breeden,¹ C. Larsen,¹ J. Tso,² A. Adams.¹
¹Emory Transplant Center, Emory University, Atlanta, GA; ²JN Bioscience, Mountanview, CA.
Introduction: Effective T cell activation and effector function requires (1) cognate antigen recognition (2) appropriate costimulation and (3) successful cytokine signaling. Recently approved strategies to…
2015 American Transplant Congress
Feasibility of Regulatory T Cell Cryopreservation and Banking for Clinical Therapeutic Applications
K. Gołąb,¹ O. Savari,¹ S. Ramachandran,¹ Z. Tekin,¹ M. Tibudan,¹ J. Millis,¹ P. Trzonkowski,² P. Witkowski.¹
¹Surgery, University of Chicago, Chicago, IL; ²Immunology, Medical University of Gdansk, Gdansk, Poland.
Feasibility of clinical application of regulatory T cells (Tregs) in clinical transplantation would be improved if Tregs or pre-enriched cells for Treg isolation could be…
2015 American Transplant Congress
Pre-Operative Assessment of Body Composition in Adult Multivisceral Transplant Candidates
R. Cruz, H. Sogawa, G. Bond, K. Soltys, R. Sindhi, G. Mazariegos, A. Humar, A. DiMartini.
Department of Surgery, Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
Body Mass Index is commonly used, but is likely to be an inexact measurement of nutritional status. For this reason, we examined whether body composition…
2015 American Transplant Congress
Clinical Outcome of Patients With De Novo C1q Binding Donor-Specific HLA Antibodies After Renal Transplantation
J. Bamoulid,¹ A. Roodenburg,² O. Staeck,¹ C. Schoenemann,² N. Lachmann,² K. Budde.¹
¹Nephrology, Charite Hospital-University of Medicine, Berlin, Germany; ²HLA Laboratory, Charite Hospital-University of Medicine, Berlin, Germany.
A. Not all de novo donor-specific HLA antibodies (dnDSA) are causing immediate graft loss. The importance of complement-binding DSA was recently shown with a commercial…
2015 American Transplant Congress
Age-Specific Graft Failure Rates in Pediatric Heart Transplant Recipients
B. Foster,¹ M. Dahhou,¹ X. Zhang,¹ V. Dharnidharka,² V. Ng,³ J. Conway.⁴
¹Pediatrics, Research Institute of the McGill Univ. Health Centre, Montreal, QC, Canada; ²Pediatrics, Washington Univ., St. Louis, MO; ³Pediatrics, Hospital for Sick Children, Toronto, ON, Canada; ⁴Pediatrics, Stollery Children's Hospital, Edmonton, AB, Canada.
Graft failure risk has been shown to peak during emerging adulthood (18-25 y) among kidney transplant recipients. The association between age and graft failure risk…
2015 American Transplant Congress
Improving Latent Tuberculosis Diagnosis Before Kidney Transplantation in a Developing Country
G. Meinerz,^1,2 C. da Silva,^1,2 E. Keitel,^1,2 A. Pasqualotto,³ J. Goldani,^1,2 C. Zeni,^1,4 F. Vacilotto,^1,4 N. Prado,^1,4 A. Monteiro,^2,3 D. Seelig,¹ F. Klaus,¹ J. Andrade,¹ V. Garcia.¹
¹Nephrology and Kidney Transplantation, Irmandade Santa Casa de Misericordia de Porto Alegre - ISCMPA, Porto Alegre, Rio Grande do Sul, Brazil; ²Programa de Pós-Graduação em Patologia, Universidade Federal de Ciencias da Saude de Porto Alegre - UFCSPA, Porto Alegre, Rio Grande do Sul, Brazil; ³Laboratorio de Biologia Molecular, Irmandade Santa Casa de Misericordia de Porto Alegre - ISCMPA, Porto Alegre, Rio Grande do Sul, Brazil; ⁴Programa de Residência em Nefrologia, Universidade Federal de Ciencias da Saude de Porto Alegre - UFCSPA, Porto Alegre, Rio Grande do Sul, Brazil.
Introduction: Tuberculosis has shown to be a great challenge in kidney transplantation, specially in developing countries due to the difficulties in diagnosis and treatment, leading…
2015 American Transplant Congress
Mesenchymal Stem Cells Prevent Cold Ischemia-Reperfusion Injury in Lung Transplants
H. Wang,^1,2 W. Tian,¹ Y. Liu,³ X. Dai,¹ G. Li,³ T. Liu,^1,2 Z. Zhang,^1,2 C. Du.⁴
¹Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China; ²Tianjin General Surgery Institute, Tianjin, China; ³Department of Biology, Tianjin Medical University, Tianjin, China; ⁴Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, Canada.
Background: Cold ischemia-reperfusion injury (IRI) is a major cause of graft failure in lung transplantation. Despite therapeutic benefits of mesenchymal stem cells (MSCs) in attenuating…
2015 American Transplant Congress
Human Gingival Tissue-Derived Mesenchymal Stem Cells Reduce Murine Acute GVHD Via Killing of Effector CD8+ Cells Through CD39/Adenosine A1R and A2BR Pathways
J. Gu, L. Ling.
Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Human gingival tissue-derived mesenchymal stem cells (GMSCs) are a convenient source of MSCs that have been shown to treat autoimmune disease. Here we use human…
2015 American Transplant Congress
Ischemia-Induced Endoplasmic Reticulum Stress Regulates Autophagy to Determine the Severity of Liver Ischemia Reperfusion Injury
H. Zhou,^1,2 J. Zhu,¹ S. Yue,¹ R. Busuttil,¹ J. Kupiec-Weglinski,¹ Y. Zhai.¹
¹The Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA; ²Liver Transplant Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Both endoplasmic reticulum (ER) stress and autophagy have been implicated in the pathogenesis of ischemia and reperfusion injury (IRI). As essential cellular stress responses against…
2015 American Transplant Congress
Enhancing Kidney Function Following DCD Donation With Thrombolytic Therapy: A Preliminary Report of a Multicenter Prospective Quasi-Blinded Randomized Trial
K. Woodside,¹ D. Goldfarb,² J. Rabets,² E. Sanchez,¹ D. Lebovitz,³ J. Schulak,¹ J. Fung,² B. Eghtesad.²
¹Transplant Institute, University Hospitals Case Medical Center, Cleveland, OH; ²Transplant Center, Cleveland Clinic, Cleveland, OH; ³LIfebanc, Cleveland, OH.
Kidneys from donors following cardiac death (DCD) are at risk for inferior outcomes, possibly due to microthrombi and additional warm ischemia. We describe an organ…