Am J Transplant, Volume 5, Suppl 3 Archives - Page 4 of 170 - ATC Abstracts

2015 American Transplant Congress
Extended Life-Supporting Xenogeneic Lung Function With Multi-Transgeneic Donor Pigs and Targeted Drug Treatments
L. Burdorf,¹ E. Rybak,¹ T. Zhang,¹ D. Harris,¹ S. Dahi,¹ N. Kubicki,¹ D. Parsell,¹ E. Sievert,¹ D. Ayares,² A. Azimzadeh,¹ R. Pierson III.¹
¹University of Maryland, Baltimore; ²Revivicor, Blacksburg.
Purpose: Prolonged life-supporting (LS) xenolung function has proven difficult to accomplish. Here we report results from 21 xLTXs in a rigorous, LS pig-to-baboon model, asking…
2015 American Transplant Congress
Th17-Mediated Alloimmune Responses Play a Key Role in Intestinal Allograft Rejection in Humans
A. Kroemer, S. Wanta, J. Diaz, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein.
The Georgetown Transplant Institute, Washington, DC.
The majority of transplanted intestines still falls victim to allograft enteropathy, the underlying mechanisms of which are poorly understood. The purpose of this study was…
2015 American Transplant Congress
Proteasome Activation During Renal Cold Storage and Transplantation: A Novel Pathway for Mitochondrial Destruction?
N. Parajuli, L. MacMillan-Crow.
Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR.
Purpose: Renal cold storage (CS) is considered to be an alloantigen-independent risk factor for long-term transplant outcome. The precise molecular mechanisms responsible for CS-related renal…
2015 American Transplant Congress
Prospects of Differentiating T-Cell Mediated Rejection (TCMR) from BK Virus Nephropathy (BKVN) Using Next Generation Sequencing (NGS) of the T-Cell Receptor (TCR)
G. Zeng, Y. Huang, P. Randhawa.
Pathology, University of Pittsburgh, Pittsburgh, PA.
Histopathology cannot determine whether T-cell infiltrates in renal allograft biopsies recognize donor HLA or BKV antigens. The ability of a T-cell to respond in an…
2015 American Transplant Congress
Post-Transplant Changes in Serum Creatinine and Beta-2 Microglobulin Predict Acute Tubular Necrosis in the Early Post-Transplant Period
P. Liu,¹ A. Djamali,^1,2 D. Kaufman,^2,1 B. Astor.¹
¹Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI; ²Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Purpose: To evaluate the utility of early post-transplant changes in serum creatinine (SCr) and beta-2 microglobulin (B2M) in differentiating acute tubular necrosis (ATN) and other…
2015 American Transplant Congress
Excellent Outcomes of Prophylactic Rituximab Administration With Plasmapheresis in Kidney Transplant Recipients With Focal Segmental Glomerulosclerosis
M. Okumi,¹ Y. Miyauchi,² T. Yagisawa,¹ K. Unagami,¹ D. Toki,¹ K. Omoto,¹ H. Ishida,¹ K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan; ²Urology, Ehime University, Matsuyama, Ehime, Japan.
[Background]The estimated recurrence rate of focal segmental glomerulosclerosis (FSGS) after kidney transplantation is approximately 30%. Relapse occurring immediately after transplantation is refractory to treatment and…
2015 American Transplant Congress
Thymoglobulin Administration During Multi-Visceral and Isolated Small Bowel Procurement Does Not Adversely Affect the Survival of Harvested Organs
G. Jain, T. Burnett, J. Preheim, L. Vargas, W. Grant, A. Langnas, D. Mercer, G. Jain.
Division of Transplantation, Department of Surgery, University of Nebraska Medical Center, Omaha, NE.
Anti-thymocyte globulin administration in donors before intestinal procurement may result in decreased graft versus-host disease (GVHD) due to reduced recipient lymphocyte trafficking after reperfusion. Reluctance…
2015 American Transplant Congress
Late Onset Cluster of Pneumocystis Jirovecii Pneumonia (PJP) in Renal Transplant Patients: Re-Examining Prophylaxis Strategies
G. Sekhon,¹ L. Gunaratnam,¹ H. Iyer,¹ J. Johnson,¹ N. Muirhead,¹ A. Newman,² F. Rehman,¹ M. Weir,¹ M. Silverman,³ A. House,¹ A. Jevnikar,¹ S. Hosseini-Moghaddam.³
¹Division of Nephrology, Department of Medicine, London Health Sciences Centre, Western University, London, ON, Canada; ²Coordinator, Infection Prevention and Control, London Health Sciences Centre, London, ON, Canada; ³Division of Infectious Diseases, Department of Medicine, London Health Sciences Centre, Western University, London, ON, Canada.
PJP may be associated with severe pulmonary involvement in kidney transplant recipients. We have had a long term policy of routine prophylaxis for 1 year…
2015 American Transplant Congress
Microcirculation Inflammation in Early Surveillance Renal Biopsy in Sensitized Patients Did Not Correlate With Graft Outcome
P. Souza,¹ D. Machado,¹ D. David,¹ G. Bezerra,¹ F. Jota de Paula,¹ H. Rodriges,² W. Nahas,¹ E. David Neto,¹ M. Castro.¹
¹Renal Transplant Unit, HC - FMUSP, S Paulo, SP, Brazil; ²Lab de HLA, InCor, S Paulo, SP, Brazil.
Introduction: Microcirculation inflammation (MI) at 3-month renal biopsies and preformed donor-specific antibodies (DSA) are considered predictors of bad outcome in sensitized patients. Earlier biopsies and…
2015 American Transplant Congress
DQB1 Epitope Matching Predicts the Development of De Novo DSA and Antibody Mediated Rejection
M. Willicombe,¹ M. Blow,² P. Brookes,² E. Santos,² D. Taube.¹
¹Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, United Kingdom; ²H&I, Hammersmith Hospital, London, United Kingdom.
HLA DQ antibodies are the commonest de novo [DN] DSA specificity seen post renal transplantation. Their presence is associated with antibody mediated injury and allograft…