2015 American Transplant Congress
Delayed Kidney Transplant in Combined Liver-Kidney Transplantation Improves GFR and Patient Survival
Transplant Division, Department of Surgery, Indiana University, Indianapolis.
Background: Patients requiring combined liver-kidney transplantation (LKTx) are at risk for worse outcomes compared to LTx and KTx alone due to severity of illness and…2015 American Transplant Congress
Liver Allograft Provides Immunoprotection for the Cardiac Allograft in Combined Heart-Liver Transplantation
When transplanted simultaneously, the liver allograft has been thought to have an immunoprotective role on other organs. However, detailed studies on simultaneous heart-liver transplantation (SHLT)…2015 American Transplant Congress
Should Only Active Candidates Define the EPTS Top 20% in the New Kidney Allocation System (KAS)?
1UNOS, Richmond, VA; 2Univ Hosp Case Med Ctr, Cleveland, OH; 3Yale, New Haven, CT.
Background: The 20% of kidney candidates with the highest Estimated Post-Transplant Survival (EPTS) receive priority for a high longevity kidney in the Organ Procurement and…2015 American Transplant Congress
Early Allograft Dysfunction Causes Inferior Patient and Allograft Survival in Liver Transplantation; an Experience of 1952 Consecutive Liver Transplants
Transplantation, Mayo Clinic, Jacksonville, FL.
Background: Early allograft dysfunction (EAD) in liver transplantation (LT) is a useful intermediate outcome measure to predict graft loss or mortality. We sought to investigate…2015 American Transplant Congress
Broader Geographic Sharing of Adolescent Lung Donors Improves Allocation Efficiency
Allocating pediatric donor lungs to pediatric lung transplant (TXP) candidates results in better graft function. However, 87% of adolescent (ADL) donor lungs are allocated to…2015 American Transplant Congress
Sequential Monitoring and Stability of Ex Vivo-Expanded Autologous and Non-Autologous Regulatory T Cells Following Infusion in Non-Human Primates
1University of Pittsburgh, pittsburgh, PA; 2University of Wisconsin, Madison.
Ex vivo-expanded cynomolgus monkey CD4+CD25+CD127- regulatory T cells (Treg) maintained Foxp3 demethylation status at the Treg-Specific Demethylation Region (TSDR), and potently suppressed T cell proliferation…2015 American Transplant Congress
Plasma Levels of Donor-Derived Cell-Free DNA Increase With Rejection and Often Decrease After Treatment in Organ Transplant Recipients
1CareDx, Inc, Brisbane, CA; 2Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a potential biomarker of acute cellular rejection (ACR) in organ transplant recipients. dd-cfDNA levels in longitudinal plasma samples from…2015 American Transplant Congress
Outcome of Bortezomib/Plasmapheresis for the Sensitized Patient Awaiting Heart Transplant
Cedars-Sinai Heart Institute, Los Angeles, CA.
Purpose: Allosensitization of patients (pts) awaiting heart transplantation is a significant challenge as it prolongs the time to transplant, increases wait-list mortality and increases risk…2015 American Transplant Congress
Aquaporin 4 Blockade Is a Novel Strategy Targeting Ischemia/Reperfusion Injury in Heart Transplantation
1Immunology, Cleveland Clinic, Cleveland, OH; 2Aeromics, LLC, Cleveland, OH.
Aquaporin 4 (AQP4) belongs to the family of small integrin transmembrane proteins that are highly permeable to water. It was recently shown that human and…2015 American Transplant Congress
Impact of Community Risk on Early Hospital Readmission Following Kidney Transplant
Background: Early hospital readmission (EHR) is associated with increased morbidity, mortality, and cost in kidney transplantation (KT). Community risk may be associated with EHR above…
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