2015 American Transplant Congress
Elevated ST2 Levels Are Associated With Increased Risk of Antibody Mediated Rejection in Heart Transplant Recipients
Objective: Serum ST2, a member of the interleukin (IL) 1 receptor family, is a novel biomarker that reflects cardiac remodeling and fibrosis and is associated…2015 American Transplant Congress
Distinct Blood and Biopsy Meta-Signatures for Acute Rejection Post Kidney Transplant
Acute rejection (AR) is a major cause of allograft dysfunction. Molecular signatures of AR from blood and biopsy have been identified by several independent cohort…2015 American Transplant Congress
Etiology, Incidence and Outcomes of the Highly Sensitized Kidney Transplant Patient
University of Wisconsin, Madison, WI.
Background: Sensitization to HLA antigens is a major barrier to kidney transplantation. We sought to determine the etiology, incidence and outcomes of kidney transplants performed…2015 American Transplant Congress
Reduced Incidence of Cytomegalovirus Infection in Kidney Transplant Recipients Receiving Everolimus
BACKGROUND: CMV infection is associated with inferior long-term kidney transplant outcomes. This study compared the incidence of CMV infection/disease in de novo kidney transplant recipients…2015 American Transplant Congress
Pancreas Transplantation Immunosuppression Induction With Rabbit Antithymocyte Globulin +/- Rituximab and Early Steroid Withdrawal: Experience With >500 Recipients
T-cell depleting antibody induction, often combined with steroid withdrawal, has become standard practice for pancreas transplantation. In this study, outcomes of >500 pancreas transplants using…2015 American Transplant Congress
Donor Specific Expansion of Regulatory T-Cells Was Associated With Allograft Tolerance Induced By Transient Mixed Chimerism in Nonhuman Primates
Transplant Center, Massachusetts General Hospital, Boston, MA.
Background: We have previously reported successful induction of solid organ allograft tolerance in nonhuman primates (NHP) via a mixed chimerism approach. Since these recipients achieved…2015 American Transplant Congress
The Molecular Landscape of Atrophy-Fibrosis in Human Kidney Transplants: The Dominant Role of Acute Parenchymal Injury
University of Alberta, Edmonton, Canada.
We studied the effect of time post-transplant on atrophy-fibrosis (AF) and molecular associations with AF in 703 kidney transplant indication biopsies (bx) 3 days to…2015 American Transplant Congress
Lymphotoxin Controls Treg Interactions With Lymphatic Endothelial Cells and Interstitial Migration In Vivo
University of Maryland, Baltimore, MD.
Introduction: Lymphotoxin (LT) coordinates the development, organization and structure of lymphoid organs, and LTβreceptor (LTβR) is involved in thymocyte migration. However, LT has no described…2015 American Transplant Congress
Protecting Older Patients from Dialysis: The Survival Benefit of Preemptive Transplant With High KDPI Allografts
BACKGROUND: Mortality on dialysis remain markedly elevated in patients over 60 years old. Preemptive kidney transplantation (PreKT) represents a means of avoiding the risks of…2015 American Transplant Congress
Induction of a Costimulation-Susceptible Repertoire: A Case for Depletional Prior to Belatacept
1Surgery, Duke University, Durham, NC; 2Transplant Center, Emory University, Atlanta, GA.
Belatacept offers highly specific costimulation blockade to prevent recipient alloimmune responses with reduced toxicity. However, when applied with nondepletional induction therapy belatacept-based regimens have higher…
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