ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    CMV-Specific CD154+T-Cells and CMV Disease Status After Liver Or Intestine Transplantation (LTx, ITx)

    C. Ashokkumar,1 M. Ningappa,1 G. Mazariegos,1 K. Soltys,1 G. Bond,1 C. Trautz,1 M. Green,2 M. Michaels,2 R. Sindhi.1

    1Transplant Surgery, University of Pittsburgh, Pittsburgh, PA; 2Infectious Diseases, University of Pittsburgh, Pittsburgh, PA.

    Background: Preliminary data suggest that measuring host cellular immunity using CMV-specific IFNg+T-cells can potentially enhance decision making about discontinuation of antiviral therapy and secondary prophylaxis…
  • 2015 American Transplant Congress

    Ex Vivo Lung Perfusion: Revisit to the Optimal Oxygenation Circulating Lungs for Graft Preservation

    K. Noda, S. Haam, J. D'Cunha, J. Luketich, C. Bermudez, N. Shigemura.

    Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

    AimAccumulating evidence supports increasing the role of ex vivo lung perfusion (EVLP). However, there are evidenced limitations as well as the adverse effects of current…
  • 2015 American Transplant Congress

    Precision Diagnosis in Kidney Transplantation

    P. Kadota, D. Perkins.

    Dept of Medicine, Univ of Illinois Chicago, Chicago, IL.

    ObjectiveA major objective in clinical practice, including transplantation, is to develop more focused and “personalized” approaches for both diagnosis and treatment. There have been several…
  • 2015 American Transplant Congress

    Decreased Expression of Mitochondrial Aldehyde Dehydrogenase 2 Induces Liver Injury Via Activation of the MAPK Pathway in Grafts from Brain-Dead Donors

    Z. Zhong,1 S. Ye,1 Y. Xiong,1 X. Fan,1 W. Huang,1 D. Ko,3 Y. Wang,1 Q. Ye.1,2

    1Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; 2The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; 3Massachusetts General Hospital, Department of Urology, Boston, MA.

    Objective: To determine the role of ALDH2 in the injury of liver from brain-dead donors.Methods: Using brain-dead rabbit model, the expression of ALDH2 and apoptosis…
  • 2015 American Transplant Congress

    Transient Lymphopenia Breaks Costimulatory Blockade-Based Transplant Tolerance and Initiates Allograft Rejection

    S. Iida,1 T. Suzuki,2 K. Tanabe,1 A. Valujskikh,3 R. Fairchild,3 R. Abe.2

    1Urology, Tokyo Women's Medical Univ, Tokyo, Japan; 2Immunology, Science University of Tokyo, Chiba, Japan; 3Immunology, Cleveland Clinic, Cleveland, OH.

    【Background and Objective】: Lymphopenia is induced by lymphoablative therapies and chronic viral infections. Lymphopenia is observed in some pathological and physiological processes, including chronic viral…
  • 2015 American Transplant Congress

    Aldosterone Acts Directly On T Cells, and Promotes Production of Inflammatory Cytokines

    J. Bagley, S. Begum, J. Iacomini.

    Department of Developmental, Molecular and Chemical Biolgy, Tufts University Medical School, Boston.

    Aldosterone is a mineralocorticoid hormone involved in the regulation of blood electrolyte concentration, blood pressure and blood volume. The primary receptor for aldosterone is the…
  • 2015 American Transplant Congress

    Serum Osteoprotegerin Levels Positively Correlate With Peripheral Arterial Stiffness in Kidney Transplantation Patients

    M.-C. Lee,1,2 G.-J. Ho,1 Y.-C. Chen,1 B.-G. Hsu.2

    1Department of Surgery, Tzu Chi General Hospital, Hualien, Taiwan; 2Department of Medicine, School of Medicine Tzu Chi University, Hualien, Taiwan; 3Department of Medicine, Tzu Chi General Hospital, Hualien, Taiwan.

    Objective: Recent studies found osteoprotegerin (OPG) is associated with increased pulse wave velocity and may reflect endothelial dysfunction. The aim of this study was to…
  • 2015 American Transplant Congress

    Cultural Domains Affecting Organ Donation in Indian Country

    T. Bongiovanni,1,3,4 J. Rawlings,2 J. Trompeta,3 M. Nunez-Smith.1

    1Dept of Surgery, UCSF, San Francisco; 2Tribal Council, New Haven, CT; 3Robert Wood Johnson Foundation, Yale School of Medicine, New Haven, CT; 4Department of Veterans Affairs, West Haven.

    Background: The prevalence of end-stage renal disease is 3.5 times greater among the >2.5 million Native Americans or Alaskan Natives (NAs) in the US than…
  • 2015 American Transplant Congress

    Correlation Between Level of Biomarkers Measured in Perfusate of Machine-Preserved ECD/DCD Kidneys and Post-Transplant Graft Function

    E. Ablorsu,1 S. Zouwail,2 P. Laftsidis,1 B. Cook,1 L. Szabo.1

    1Cardiff Transplant Unit, University Hospital for Wales, Cardiff, United Kingdom; 2The Medical Biochemistry and Immunology Department, University Hospital for Wales, Cardiff, United Kingdom.

    Background:DCD and ECD kidneys are associated with higher risk of failure compare to SCD kidneys. Therefore we see increasing need to identify sensitive tool to…
  • 2015 American Transplant Congress

    The Impact of FcγRIIA, FcγRIIIA and C1QA Genes Polymorphism On Infectious Complications Following Renal Transplantation

    L. Das, Y. Tanaka, S. Verma, S. Shimizu, K. Ide, H. Ohdan.

    Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.

    AIM- Infectious complication is the leading cause of graft and patient loss after renal transplantation (RT). Under immunosuppressive condition when acquired immunity is suppressed, components…
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