Am J Transplant, Volume 5, Suppl 3 Archives - Page 31 of 170 - ATC Abstracts

2015 American Transplant Congress
OX40 Gene: A Potential Target for the Care of Chronic T-Cell Mediated Rejection (TCMR)
F. Schena,¹ C. Curci,¹ F. Sallustio,¹ M. Trpevski,¹ G. De Palma,¹ M. Fiorentino,² M. Rossini,² M. Quaglia,³ E. Bozzola,³ S. Zanini,⁴ L. Furian,⁴ A. Toscano,⁵ E. Gallo,⁶ L. Gesualdo,² P. Stratta,³ P. Rigotti,⁴ F. Citterio,⁵ L. Biancone.⁶
¹C.A.R.S.O. Consortium, Valenzano, Italy; ²University of Bari, Bari, Italy; ³A.O.U. Maggiore della Carità, Novara, Italy; ⁴University of Padova, Padua, Italy; ⁵Cattolica Sacro Cuore University, Rome, Italy; ⁶University of Torino, Turine, Italy.
Introduction:TCMR is characterized by the reduction of vessel lumen with marked intimal thickening, fibrous hyperplasia and a strong component of leukocyte infiltrate. Aim of our…
2015 American Transplant Congress
Characterization of a Nude Mouse Model of Allosensitization Conditioned by Adoptive Transfer of Follicular T Helper Cells
I. Kim, N.-N. Chai, S. Jordan, A. Klein, G. Wu.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Follicular T helper (Tfh) cells play a critical role in follicular B cell activation and maturation during antibody responses to allograft. Here we report…
2015 American Transplant Congress
Temporal Increase in the Incidence of Post-Transplantation Lymphoproliferative Disorder in Adult Renal Transplant Recipients: Analysis of 2 US Insurance Administrative Claims Databases
T. Kou, H.-U. Meier-Kriesche, J. Preston, A. Gomez.
Bristol-Myers Squibb Company, Princeton, NJ.
Purpose: Post-transplant lymphoproliferative disorder (PTLD) is a serious complication after kidney transplant. In a prior analysis using Medicare claims database from 1995 to 2003, the…
2015 American Transplant Congress
HLA-DR Matching Improves Immunologic Outcomes in Elderly Kidney Transplant Recipients
F. Halleck, D. Khadzhynov, L. Liefeldt, P. Glander, J. Bamoulid, S. Kreimer, L. Lehner, K. Budde, O. Staeck.
Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany.
BACKGROUND: The Eurotransplant senior program (ESP) neglects HLA matching for elderly (>65y) KTR. Only few data exist regarding the influence of HLA-DR-matching on immunologic outcomes.PATIENTS…
2015 American Transplant Congress
The Role of Inflammasome Components in Renal Tubular Epithelial Cell Injury
S. Kasimsetty, A. Shigeoka, D. McKay.
Medicine, UCSD, La Jolla, CA.
Background:Inflammasomes are multiprotein complexes of pattern recognition receptors (PRRs) recognized as key triggers of cellular injury. TLRs provide the first signal for induction of the…
2015 American Transplant Congress
Diabetes Exacerbates Liver Ischemia and Reperfusion Injury By Activating the AGE-RAGE Pathway in Kupffer Cells
S. Yue, J. Zhu, J. Rao, J. Kupiec-Weglinski, R. Busuttil, Y. Zhai.
Surgery, UCLA, Los Angeles, CA.
Although pre-transplant diabetes has been documented as a risk factor for mortality post-liver transplant, the underlying mechanism remains obscure. In a murine liver partial warm…
2015 American Transplant Congress
NK Cells of Kidney Transplant Recipients Show a Reduced Capacity to Produce Cytokines But Retain Their Cytotoxic Capacity
U. Hoffmann,¹ C. Neudoerfl,¹ K. Daemen,¹ J. Keil,¹ C. Blume,^2,3 F. Lehner,⁴ H. Haller,² C. Falk.^1,5
¹Inst. of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; ²Dept. of Nephrology and Hypertension, Hanover Medical School, Hanover, Germany; ³Inst. of Technical Chemistry, Leibniz University Hanover, Hanover, Germany; ⁴Dept. of General, Visceral, and Transplantation Surgery, Hanover Medical School, Hanover, Germany; ⁵German Center for Infection Research, Braunschweig, Germany.
The role of NK cells in either graft rejection or tolerance induction is still discussed controversially. In order to clarify the effect of long-term immunosuppression…
2015 American Transplant Congress
Pharmacokinetics of Everolimus (EVL) in Elderly Recipients Under Low-Tacrolimus(TAC)/Everolimus in the First Year After Renal Transplantation. Data from the NEverOLd Trial
E. David-Neto,¹ P. Romano,² F. Agena,¹ P. Ebner,² A. Triboni,¹ F. Ramos,¹ N. Galante,¹ F. Lemos.¹
¹Renal Transplantation Service, Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil; ²Division of Central Laboratory, Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil.
Elderly ( >60 years) recipients are being renal transplanted more frequently. The pharmacokinetics studies (PK) of immunosuppressive drugs in healthy volunteers, rarely, if ever, include…
2015 American Transplant Congress
mTOR-Based CNI Minimization Vs Withdrawal in African American Kidney Transplant Recipients
J. Fleming,¹ D. Taber,² N. Pilch,¹ H. Meadows,¹ C. Mardis,¹ J. McGillicuddy,² S. Nadig,² K. Chavin,² P. Baliga,² C. Bratton.²
¹Pharmacy, Medical University of South Carolina, Charleston, SC; ²Surgery, Medical University of South Carolina, Charleston, SC.
The purpose of this study was to compare mTOR-based CNI withdrawal vs. minimization in African American (AA) kidney transplant (KTx) recipients.METHODS: This was a single-center,…
2015 American Transplant Congress
A Noninvasive Diagnostic Test of Renal Allograft Rejection Using Urinary-Cell mRNA: A Comparison of Droplet Digital and Real-Time PCR
J.-W. Seo, H. Moon, A. Lee, Y.-W. Choi, Y. Kim, J.-Y. Moon, S.-H. Lee.
Division of Nephrology, Department on Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Background: The diagnosis of acute rejection in kidney transplantation is still standardized by an invasive renal biopsy. Noninvasive tests and biomarkers that can replace the…