ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    A New Diagnostic and Pronostic Tool for Antibody Mediated Rejection in Kidney Transplantation: Intragraft Donor Specific Anti-HLA Antibodies Detection

    J. Olagne,1,2,3 A. Parissiadis,2 S. Caillard,1 N. Froelich,2 L. Marcellin,3 C. Muller,1 G. Gautier-Vargas,1 P. Perrin,1 L. Braun-Parvez,1 F. Heibel,1 C. Gachet,2 B. Moulin.1

    1Service de Néphrologie - Transplantation, Centre Hospitalier Universitaire, Strasbourg, France; 2Laboratoire d'Histocompatibilité, Etablissement Français du Sang, Strasbourg, France; 3Département de Pathologie, Centre Hospitalier Universitaire, Strasbourg, France.

    INTRODUCTION: Antibody mediated rejection (AMR) is one of the main cause of loss of the kidney transplant. Despite the new BANFF classification, diagnostic difficulties and…
  • 2015 American Transplant Congress

    Incidence of De Novo Donor Specific Antibodies in Kidney Transplant Recipients

    C. Staino, N. Pilch, O. Moussa, K. Boyle, J. Casale, K. Covert, J. Fleming, D. Taber, H. Meadows, C. Mardis, K. Chavin, S. Nadig, J. McGillicuddy, C. Bratton, T. Srinivas, P. Baliga.

    MUSC, Charleston, SC.

    The reported incidence and risk factors for the development of de novo donor specific antibodies (dnDSA) are variable. Although dnDSA is a negative predictor of…
  • 2015 American Transplant Congress

    Low Expanded Criteria Donor Listing Rates by Organ Procurement Organization Is Associated With Increased Differential in Waiting Time for Candidates Willing to Accept Marginal Organs in the US

    D. Keith, A. Nishio Lucar, G. Vranic.

    Medicine, University of Virginia, Charlottesville, VA.

    Organ procurement organization (OPO) listing rates for expanded criteria donor (ECD) kidneys vary greatly across the US. The goal of ECD listing is to shorten…
  • 2015 American Transplant Congress

    Long Term Outcomes With Alemtuzumab Induction Therapy for Deceased and Living Renal Transplant Recipients. A Single Center Experience

    P. Vaitla, U. Patel, A. Cruz, S. Guisti, A. Moiz, C.-S. Catherine, A. Cohen, G. Loss, H. Bohorquez, I. Carmody, T. Reichman, D. Bruce, S. Anders, J. Garces.

    Ochsner Clinic Foundation, New Orleans, LA.

    Background:Antibody induction therapy has been used for induction in up to 80% kidney transplant recipients according to United Network for Organ Sharing. It has been…
  • 2015 American Transplant Congress

    Effect of Everolimus on Cardiovascular Parameters in De Novo Kidney Transplant Recipients: 12-Month Results from the ELEVATE Study

    H. Holdaas,1 M. van der Giet,1 J. de Fijter,1 A. Speziale,2 C. Escrig,2 G. Junge,2 Z. Wang,3 J. Cruzado.1

    1For the ELEVATE Study, Oslo, Norway; 2Novartis, Basel, Switzerland; 3Novartis Corporation, East Hanover, NJ.

    Background: Long-term exposure to calcineurin inhibitors (CNIs) contributes to an unfavorable cardiovascular (CV) risk profile, including inferior renal allograft function and premature graft loss with…
  • 2015 American Transplant Congress

    Interferon-Free Sofosvir/Ribavirin Treatment Achieves Excellent Sustained Viral Response in Post Liver Transplant HCV Recipients

    M. Hamshow, K. Bortecen, R. Layman, A. Winnick, B. Gelb, G. Morgan, L. Teperman.

    Transplant Surgery, NYU Langone Medical Center,The Mary Lea Johnson Richards Organ Transplant Center, New York, NY.

    Purpose: HCV is the leading cause of end-stage liver disease, universally recurring in the post-transplant setting. Studies have shown disappointing results after first generation protease…
  • 2015 American Transplant Congress

    Basiliximab Induction With Delayed Tacrolimus Initiation up to 14 Days Post Liver Transplantation Maintains Excellent Clinical Outcomes While Preserving Renal Function

    J. Werth, W. Ally, D. Maluf, S. Pelletier.

    University of Virginia Health System, Charlottesville, VA.

    Background: Calcineurin inhibitors are frequently delayed to allow for recovery of renal function after transplantation; however, there is a paucity of literature supporting a delay…
  • 2015 American Transplant Congress

    Hospital Characteristics Mediate Variation in Cirrhosis Mortality in Transplant and Non-Transplant Facilities

    A. Mathur,1 A. Chakrabarti,2 K. Sheetz,2 J. Mellinger,3 M. Volk,3 N. Katariya,1 A. Singer,1 W. Hewitt,1 K. Reddy,1 A. Moss.1

    1Surgery, Mayo Clinic Arizona, Phoenix, AZ; 2Surgery, University of Michigan, Ann Arbor, MI; 3Medicine, University of Michigan, Ann Arbor, MI.

    Hospitals vary significantly in cirrhosis mortality. We aimed to determine whether hospital structural characteristics mediate this effect.Methods: We used 2009 data from the HCUP Nationwide…
  • 2015 American Transplant Congress

    Factors Associated With Rehospitalization and High Cost Among Health Plan Members Receiving Kidney Transplants

    E. Lee,1 Y. Zhou,2 B. Suehs,2 B. Franks,1 B. Kassman,1 J. Spalding,1 G. Thal.1

    1Astellas Scientific and Medical Affairs, Northbrook, IL; 2Comprehensive Health Insights, Humana, Louisville, KY.

    PurposeAims were to develop a claims-based algorithm to identify kidney transplant cases and to examine clinical and economic outcomes among health plan members undergoing kidney…
  • 2015 American Transplant Congress

    Effects of Heart and Lung Co-Transplantation Across a Full MHC Barrier in Miniature Swine

    M. Madariaga, P. Spencer, S. Michel, G. La Muraglia II, M. O'Neil, E. Mannon, C. Leblang, I. Rosales, R. Colvin, D. Sachs, J. Allan, J. Madsen.

    Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

    Background: We have previously shown that tolerance of heart allografts across a full MHC barrier can be induced in miniature swine after a 12-day course…
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