ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    A New Diagnostic Tool for Antibody Mediated Rejection in Heart and Lung Transplantation: Intragraft Donor Specific Anti-HLA Antibodies Detection

    J. Olagne,1,2,3 A. Parissiadis,2 N. Froelich,2 S. Caillard,1 M.-P. Chenard,3 E. Epailly,4 H. Kremer,4 T. Degot,5 S. Hirschi,5 R. Kessler,5 B. Moulin.1

    1Service de Néphrologie - Transplantation, Centre Hospitalier Universitaire, Strasbourg, France; 2Laboratoire d'Histocompatibilité, Etablissement Français du Sang, Strasbourg, Alsace, France; 3Département de Pathologie, Centre Hospitalier Universitaire, Strasbourg, France; 4Service de Cardiologie, Centre Hospitalier Universitaire, Strasbourg, France; 5Service de Pneumologie, Centre Hospitalier Universitaire, Strasbourg, France.

    INTRODUCTION: Antibody mediated rejection (AMR) is one of the causes of dysfunction and graft loss. The limited histological features, with a weak sensibility of c4d,…
  • 2015 American Transplant Congress

    Immunomodulatory Effects of Neuropilin-2 On T Cells

    H. Nakayama,1,2 N. Kochupurakkal,1 S. Bruneau,1 D. Bielenberg,2 M. Klagsbrun,2 D. Briscoe.1

    1Transplant Research Program, Boston Children's Hospital, Boston, MA; 2Vascular Biology Program, Boston Children's Hospital, Boston, MA.

    Axonal guidance molecules are expressed within the immune system and elicit anti-inflammatory effects with potential to target auto- and alloimmunity. The neuropilin (NRP) family receptors…
  • 2015 American Transplant Congress

    Hepatocyte-Related miR-193a-3p Is Over-Expressed in Allograft Biopsy from Liver Tolerant Recipients

    R. Danger, J. Lozano, E. Bonaccorsi-Riani, E. Kodela, R. Mas-Malavila, M.-C. Londono, M. Martinez, A. Rimola, M. Martinez-Llordella, A. Sanchez-Fueyo.

    Department of Liver Sciences, Faculty of Life Sciences & Medicine, MRC Transplant Centre, King's College London, London, United Kingdom; Liver Unit and Bioinformatic Platform, IDIBAPS, University of Barcelona and Hospital Clinic Barcelona, Barcelona, Spain.

    While liver transplantation is the treatment of choice for end-stage liver diseases, its success is compromised by the need to administer life-long immunosuppression, which negatively…
  • 2015 American Transplant Congress

    Epidemiology and Outcomes of Non Tuberculous Mycobacterial (NTM) Infections in Solid Organ Transplant (SOT) Recipients

    I. George, C. Santos, M. Olsen, T. Bailey.

    Infectious Diseases, Washington University School of Medicine, St. Louis, MO.

    Background: NTM are uncommon causes of infection in SOT recipients but may cause significant morbidity and mortality.Methods: A retrospective cohort of all patients who underwent…
  • 2015 American Transplant Congress

    Tandem P-Selectin Glycoprotein Ligand-Immunoglobulin (TSGL-Ig) Protects Liver Endothelial Cells Against Prolonged Cold Preservation Injury in Mouse Liver Transplantation

    C. Zhang,1 H. Ji,1 Y. Liu,1 X. Shen,1 F. Gao,1 R. Busuttil,1 G. Shaw,2 J. Kupiec-Weglinski.1

    1Dept of Surgery, Dumont-UCLA Liver Transplant Center, Los Angeles, CA; 2Quell Pharma Inc., Half Moon Bay, CA.

    Background: Liver endothelial cell (LEC) damage is central in the pathogenesis of hepatic ischemia-reperfusion injury (IRI). LEC detachment/progressed denudation are typical during cold storage and…
  • 2015 American Transplant Congress

    Patient and Process-Level Factors Associated With Kidney Transplant Readmissions

    K. Covert, J. Fleming, C. Staino, J. Casale, K. Boyle, N. Pilch, H. Meadows, C. Mardis, J. McGillicuddy, C. Bratton, T. Srinivas, K. Chavin, P. Baliga, D. Taber.

    MUSC, Charleston, SC.

    Readmissions following kidney transplantation (KTX) are common, with complex etiologies. There is a lack of research exploring the potential of optimizing post-transplant processes to reduce…
  • 2015 American Transplant Congress

    Clinical and Radiological Predictors of Transplant Renal Artery Stenosis (TRAS)

    H. Wadei,1 D. Hodge,2 L. White,2 A. Ayub,3 N. Aslam,3 T. Gonwa,1 G. Frey,4 D. Sella,4 M. Mai.1

    1Transplant, Mayo Clinic, Jacksonville, FL; 2Biomedical Statistics, Mayo Clinic, Jacksonville, FL; 3Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL; 4Diagnostic Radiology, Mayo Clinic, Jacksonville, FL.

    Elevated peak systolic velocity (PSV) on Doppler ultrasound at the transplant renal artery (TRA) does not always correlate with true transplant renal artery stenosis (TRAS)…
  • 2015 American Transplant Congress

    Non-Chimeric HLA-Identical Renal Transplant Tolerance: Regulatory Immunophenotypic/Genomic Biomarkers

    J. Leventhal,1 J. Mathew,1 D. Salomon,2 S. Kurian,2 J. Friedewald,1 L. Gallon,1 I. Konieczna,1 A. Tambur,1 J. Levitsky,1 Y. Kanwar,1 C. Jie,1 M. Abecassis,1 J. Miller.1

    1CTC, Northwestern University, Chicago, IL; 2Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA.

    Background. We previously described 3-year results of a non-chimeric tolerance protocol in HLA-identical living donor renal transplant (RT) recipients and now report on longer term,…
  • 2015 American Transplant Congress

    Controlling Alloreactive B Cell Responses in Sensitized Recipients With CTLA-4Ig

    J. Chen,1 Q. Wang,1 D. Yin,1 V. Vu,1 R. Sciammas,2 A. Chong.1

    1Depart of Surgery, University of Chicago, Chicago; 2Immunobiology Transplant Center, Houston Methodist Research Institute, Houston.

    Sensitized recipients are defined by the presence of pre-transplant donor-specific antibodies and have significantly poorer graft outcomes compared to unsensitized recipients despite efforts to desensitize.…
  • 2015 American Transplant Congress

    Effect of Patient Functional Status on the Associations Between Kidney Transplant Waitlisting, Race, and U.S. Region

    L. Plantinga, R. Patzer, S. Pastan, C. Bowling.

    Emory University, Atlanta.

    Background: Black race and Southeastern residence at the start of end-stage renal disease (ESRD) are associated with reduced access to the U.S. kidney transplant waitlist,…
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