2015 American Transplant Congress
NKp46 Clusters at the NK Cell Immune Synapse Regulate Specific Effector Functions
1Stanford University, Stanford, CA; 2Ben Gurion University of the Negev, Beer Sheva, Israel.
Natural Killer (NK) cells play an important role in the first-line defense against tumor and virus-infected cells. Studies suggest NK cells have a dichotomous role…2015 American Transplant Congress
Kidney Transplantation Using Kidneys from Donation After Circulatory Death Donors: Results from the UK Experience
Introduction: Kidneys from donation after circulatory-death donors currently make up over 40% of deceased donor kidney transplants in the UK. In addition, 34% of deceased…2015 American Transplant Congress
Independent Prognostic Factors for Survival in Hepatocellular Carcinoma Patients Undergoing Orthotopic Liver Transplantation: UNOS Population Study
Background: The impact of regional differences in bridging locoregional therapy (LRT) use and wait times on overall survival (OS) in hepatocellular carcinoma (HCC) patients undergoing…2015 American Transplant Congress
LFA-1 Is Crucial for Germinal Center Reconstruction After T cell Depletion and IL-21 Biased Antibody-Mediated Rejection
1Surgery, Emory Transplant Center, Atlanta, GA; 2Surgery, Duke University, Durham, NC.
[Background] Lymphocyte depletion prior to transplantation is beneficial in reducing initial maintenance immunosuppression in transplantation. However, despite its excellent efficacy in controlling T cell mediated…2015 American Transplant Congress
Peritransplant Costimulation Blockade and Rapamycin Therapy Induces Permanent Limb Allograft Survival
Aim: Using murine models, we sought to identify the mechanisms of responsible for vascularized composite allotransplant (VCA) rejection, and to thereafter, using clinically relevant peri-transplant…2015 American Transplant Congress
Characteristics and Outcomes of Renal Transplant Recipients With Hemolytic Uremic Syndrome: An OPTN Registry Analysis
Hemolytic uremic syndrome (HUS) accounts for <1% of renal transplants in the US. There is limited data on the characteristics and outcomes of in pediatric…2015 American Transplant Congress
Increased Cytotoxic and Regulatory T Cell and B Cell Associated Gene Transcripts in Transplant Kidney Biopsies With Non-Specific IFTA and Interstitial Inflammation
Background: Patients with non –specific interstitial fibrosis/tubular atrophy (IFTA) have lower graft survival if their biopsies have interstitial inflammation, described as “ i” in Banff…2015 American Transplant Congress
Everolimus and Early Calcineurin Inhibitor Withdrawal Is Associated With Superior Renal Function: 5-Year Follow-Up of the Randomized PROTECT Liver Transplantation Study
PROTECT Study Group, Novartis Pharma GmbH, Germany.
Purpose: At the end of the 12-month (M) PROTECT core study (NCT00378014), de novo liver transplant recipients (LTxR) who switched from a calcineurin inhibitor (CNI)…2015 American Transplant Congress
Epstein Barr Virus Modulates Host Cell MicroRNA-194 to Promote IL-10 Production in B Cell Lymphomas
Surgery/Division of Abdominal Transplant, Stanford University School of Medicine, Stanford, CA.
Epstein Barr virus (EBV) infection is associated with the development of post-transplant lymphoproliferative disorder (PTLD) which can manifest as aggressive B cell lymphomas in transplant…2015 American Transplant Congress
Allogeneic Mature Human Monocyte-Derived Dendritic Cells Generate Superior Alloreactive Regulatory T Cells in an IL-2-Independent Manner
IntroductionExpansion of antigen (Ag)-specific natural occurring regulatory T cells (nTregs) is required to obtain sufficient numbers of cells for cellular immunotherapy. In this study, different…
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