ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    CD4 T Cell Mediated Help Is Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage

    H. Tsuda,1,4 T. Tanaka,2,4 N. Kohei,3,4 D. Kish,4 W. Baldwin,4 A. Valujskikh,4 R. Fairchild.4

    1Advanced Technology for Transplantation, Osaka Univ., Suita, Japan; 2Urology, Sapporo Medical Univ., Sapporo, Japan; 3Urology, Tokyo Women's Medical Univ., Tokyo, Japan; 4Immunology, Cleveland Clinic, Cleveland, OH.

    Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
  • 2015 American Transplant Congress

    Donor-Derived Cell-Free DNA Is Stable in Non-Rejecting Heart Transplant Recipients in the CARGO II Multicenter Trial

    D. Hiller,1 M. Grskovic,1 J. Beausang,1 R. Sit,1 B. Christie,1 J. Elechko,1 R. Woodward,1 J. Yee,1 H. Eisen.2

    1CareDx, Inc, Brisbane, CA; 2Drexel University, University of Philadelphia, Philadelphia, PA.

    Purpose: An elevated fraction of donor-derived cell-free DNA (dd-cfDNA) detected in the venous blood of recipients has been shown to be correlated to rejection of…
  • 2015 American Transplant Congress

    The Significant Association Between the Functional Polymorphism (Rs3761548) of Foxp3 Gene and the Severity of Acute Cellular Rejection in Liver Transplantation

    S. Verma, Y. Tanaka, S. Shimizu, L. Das, H. Ohdan.

    Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.

    Aim- Acute cellular rejection (ACR) accounts for 15-25% of graft failure in living donor liver transplantation (LDLT). T regulatory cells (Treg) play an important role…
  • 2015 American Transplant Congress

    Early Hospital Readmissions After Kidney Transplantation

    M. Lubetzky, M. Ajaimy, L. Kamal, G. DeBoccardo, E. Akalin, L. Kayler.

    Transplantation, Montefiore Medical Center, Bronx, NY.

    Early rehospitalization after kidney transplantation is common and is considered a quality metric. Few studies have examined preventability or specific transplant/discharge factors associated with early…
  • 2015 American Transplant Congress

    Umbilical Vein Catheter Versus Double J Stent for Ureteric Anastomosis in Renal Transplantation: A Single Centre, Open Label, Randomized Trial

    V. Swaroop, A. Pereira, S. Smith, O. Masood, R. Pararajasingam, T. Augustine, H. Riad, S. Mehra, A. Tavakoli.

    Transplant Surgery, Manchester Royal Infirmary, Manchester, United Kingdom.

    Introduction: Double J (DJ) stents are used routinely in renal transplantation to prevent ureteric complications. A recent Cochrane review of literature showed that routine prophylactic…
  • 2015 American Transplant Congress

    10 Year Experience Using a Steroid Free Three Drug Maintenance Immunosuppression Regimen for Pancreas Transplant Alone: Comparison of Induction With Rabbit Antithymocyte Globulin +/- Rituximab

    J. Fridell,1 R. Mangus,1 J. Chen,2 M. Mujtaba,3 T. Taber,3 M. Goble,1 J. Powelson.1

    1Surgery, Indiana University School of Medicine, Indianapolis, IN; 2Pharmacy, Indiana University School of Medicine, Indianapolis, IN; 3Medicine, Indiana University School of Medicine, Indianapolis, IN.

    Graft survival following pancreas transplant alone (PTA) is inferior to other pancreas transplants. Steroid elimination is appealing, but a two drug maintenance strategy may be…
  • 2015 American Transplant Congress

    ALDH Expression in Facilitating Cells Plays a Critical Role in Regulatory T Cell Induction and GVHD Prevention

    H. Xu,1 T. Miller,1 Y. Huang,1 S. Ildstad.1,2

    1Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; 2Regenerex, LLC, Louisville, KY.

    Graft-vs-host disease (GVHD) is a major source of morbidity in hematopoietic stem cell transplantation (HSCT), limiting its application to treat nonmalignant hematopoietic diseases and to…
  • 2015 American Transplant Congress

    Dialysis Facility Kidney Transplant Referral in Georgia: 2005-2012

    S. Pastan,1 J. Gander,1 L. Plantinga,1 L. Sauls,2 E. Gibney,3 L. Mulloy,4 J. Krisher,2 R. Patzer.1

    1Emory University, Atlanta; 2Southeastern Kidney Council, Raleigh, NC; 3Piedmont Hospital, Atlanta, GA; 4Georgia Regents University, Augusta, GA.

    Purpose: Significant variation exists in Standardized Transplantation Ratios (STR) at the dialysis facility level, and GA has the lowest kidney transplant (KTx) rate in the…
  • 2015 American Transplant Congress

    NKp46 Clusters at the NK Cell Immune Synapse Regulate Specific Effector Functions

    U. Hadad,1,2 T. Thauland,1 M. Butte,1 A. Porgador,2 O. Martinez,1 S. Krams.1

    1Stanford University, Stanford, CA; 2Ben Gurion University of the Negev, Beer Sheva, Israel.

    Natural Killer (NK) cells play an important role in the first-line defense against tumor and virus-infected cells. Studies suggest NK cells have a dichotomous role…
  • 2015 American Transplant Congress

    Kidney Transplantation Using Kidneys from Donation After Circulatory Death Donors: Results from the UK Experience

    D. Summers,1,2,3 R. Johnson,2 D. Collett,2 C. Watson,1,3 J. Neuberger,2 G. Pettigrew,1,3 J. Bradley.1,3

    1Department of Surgery, Cambridge University, Cambridge, United Kingdom; 2Organ Donation and Transplantation, NHS Blood and Transplant, Bristol, United Kingdom; 3Cambridge NIHR Biomedical Reseach Centre, Cambridge, United Kingdom.

    Introduction: Kidneys from donation after circulatory-death donors currently make up over 40% of deceased donor kidney transplants in the UK. In addition, 34% of deceased…
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