Am J Transplant, Volume 5, Suppl 3 Archives - Page 23 of 170 - ATC Abstracts

2015 American Transplant Congress
Effects of Late Kidney Graftectomy in Nonhuman Primates (NHPs) Tolerant of Co-Transplanted Heart and Kidney Allografts
M. Tonsho,¹ G. Benichou,¹ R. Smith,² R. Colvin,² J. Madsen.^1,3
¹MGH Transplant Center, Massachusetts General Hospital, Boston, MA; ²Pathology, Massachusetts General Hospital, Boston, MA; ³Cardiac Surgery, Massachusetts General Hospital, Boston, MA.
Co-transplantation of donor kidneys and bone marrow enables the induction of tolerance of allogeneic hearts in NHPs. We have previously demonstrated that the state of…
2015 American Transplant Congress
Rewarming of Cold Preserved Livers Decreases Graft Injury and Kupffer Cell Activation by Normothermic Extracorporeal Liver Perfusion (NELP)
B. Banan,¹ R. Watson,² Y. Lin,¹ J. Jia,¹ Z. Xiao,¹ G. Upadhya,¹ W. Chapman.¹
¹Surgery, Washington University School of Medicine, St Louis, MO; ²Anatomic & Molecular Pathology, Washington University School of Medicine, St Louis, MO.
Normothermic extracorporeal liver perfusion (NELP) is able to decrease ischemia reperfusion injury to the greatest degree when cold ischemic time is minimized. However, given the…
2015 American Transplant Congress
High-Resolution Perfusion Mapping to Detect Heart Transplant Rejection Using Contrast Enhance Ultrasound
K. Fischer,^1,2 S. Ohori,² F. Meral,¹ S. Giannini,² K. Hoffmeister,² H. Athar,² T. Ichimura,² R. Smith,³ M. Giverts,² F. Jolesz,¹ R. Abdi.²
¹Radiology, Brigham and Women's Hospital, Boston; ²Medicine, Brigham and Women's Hospital, Boston; ³Pathology, Massachusetts General Hospital, Boston.
Background: One of the key unmet needs in heart transplantation is an effective and accurate, non-invasive tool to diagnose acute and chronic heart transplant rejection.…
2015 American Transplant Congress
Losartan Benefits Are Mediated Through SIRT1 Activation in Rat Reduced Size Orthotopic Liver Transplantation
E. Pantazi,¹ M. Bejaoui,¹ M. Zaouali,¹ E. Folch-Puy,¹ A. Rolo,^2,3 A. Panisello,¹ C. Palmeira,² J. Rosello-Catafau.¹
¹Experimental Pathology, Institute of Biomedical Research of Barcelona (IIBB-CSIC), Barcelona, Spain; ²Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal; ³Center for Neurosciences and Cell Biology, Department of Zoology, University of Coimbra, Coimbra, Portugal.
Background: Silent Information Regulator 1 (SIRT1) is a histone deacetylase that has been associated with protective mechanisms against IRI, but its role in liver transplantation…
2015 American Transplant Congress
Prediction of Delayed Graft Function By Means of a Web-Based Calculator in Living Related Kidney Transplant: Mexican Single Center Experience
G. Martinez-Mier,¹ E. Soto-Miranda,¹ M. Mendez Lopez,¹ L. Budar Fernandez,¹ M. Trujillo-Martinez,² A. Uscanga-Montesano,² D. Avila y Falfan.²
¹Organ Transplantation, IMSS UMAE189/HRAEV Nefrologia y Trasplantes de Veracruz, Veracruz, Mexico; ²Research, IMSS UMAE 189, Veracruz, Mexico.
Background: Delayed graft function (DGF) is associated with, poor graft survival. Irish validated a model to predict DGF for deceased donor transplants. The model was…
2015 American Transplant Congress
Change in Health-Related Quality of Life Between Evaluation for Kidney Transplantation and Transplantation
M. McAdams-DeMarco, E. King, N. Desai, N. Dagher, B. Lonze, R. Montgomery, D. Segev.
Johns Hopkins, Baltimore.
BACKGROUND: Kidney transplantation (KT) recipients have been found to have higher Health-related quality of life (HRQOL) than patients undergoing other forms of renal replacement therapy.…
2015 American Transplant Congress
Predictors of Deceased Donor Lung Utilization in the United States
L. Edwards,¹ L. Robbins Callahan,¹ J. Rogers,² K. Chan.³
¹United Network for Organ Sharing, Richmond, VA; ²Duke University Medical Center, Durham, NC; ³University of Michigan Health System, Ann Arbor, MI.
Background: Lung utilization rates for deceased donor (DD) are far lower than most solid organs. For DD recovered in 2013, 22% had at least one…
2015 American Transplant Congress
Similar Outcomes Can Be Expected Among HIV (+) Kidney Transplant Recipients (HIV+ Tx) Vs. HIV (-) Kidney Transplant Recipients (HIV- Tx) Receiving Similar Immunosuppression Protocols
L. Panarey,¹ G. Malat,^2,3 A. Sharma,¹ K. Ranganna,¹ D. Reich,² G. Xiao,² A. Doyle.¹
¹Dept of Medicine, Drexel University College of Medicine, Philadelphia; ²Dept of Surgery, Drexel University College of Medicine, Philadelphia; ³Dept of Pharmacy, Hahnemann University Hospital, Philadelphia, PA.
Outcomes among HIV+ Tx continue to improve despite the established risk of rejection and calcineurin-nephrotoxicity. We sought to compare outcomes among HIV+ Tx vs. HIV-…
2015 American Transplant Congress
Donor Selection and Prophylactic IVIg for Induction Immunosuppression Improves Outcomes for HIV+ Kidney Transplant Recipients (HIV+ Tx)
G. Malat,^1,2 L. Panarey,³ A. Sharma,³ K. Ranganna,³ D. Reich,² G. Xiao,² A. Doyle.³
¹Dept of Pharmacy, Hahnemann University Hospital, Philadelphia; ²Dept of Surgery, Drexel University College of Medicine, Philadelphia; ³Dept of Medicine, Drexel University College of Medicine, Philadelphia, PA.
HIV+ Tx recipients are noted to have higher rates of allorecognition through cellular and humoral mediated pathways. Since 2010, our program instituted IVIg use as…
2015 American Transplant Congress
NK-Cell Subset Distribution, Renal Function and Biopsy Findings in Kidney Transplant Recipients With HLA Donor-Specific Antibodies
M. Crespo,¹ D. Redondo,¹ J. Gimeno,² J. Yelamos,³ A. Muntasell,³ A. Faura,¹ M. Pérez-Sáez,¹ M. López-Montañes,⁴ A. Torío,⁵ C. García,⁶ M. Mir,¹ J. Hernandez,⁶ M. López-Botet,^3,4 J. Pascual.¹
¹Nephrology Unit, Hospital del Mar, Barcelona, Spain; ²Servicio de Anatomía Patológica, Hospital del Mar, Barcelona, Spain; ³Servicio de Inmunología, Institut Mar d'Investigacions Mediques, Barcelona, Spain; ⁴Universitat Pompeu Fabra, Barcelona, Spain; ⁵Laboratori de Referencia de Catalunya, Barcelona, Spain; ⁶Immunology Department, Hospital de Alicante, Alicante, Spain.
Background: Detection of post-transplant donor-specific anti-HLA antibodies(DSA) constitutes a risk factor for kidney transplant (KT) loss. NK-cell antibody-dependent cell mediated cytotoxicity(ADCC) has been proposed to…