ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Murine Veno-Arterial Extracorporeal Membrane Oxygenation (mVA-ECMO): A Novel Tool to Study the Molecular Biology of Mechanical Circulatory Support

    A. Schenk,1 J. Fallon,1 M. Farrell,1 R. Halter,2 J. Yun.3

    1Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH; 2Thayer School of Engineering, Dartmouth College, Hanover, NH; 3Cardiothoracic Surgery, Yale New-Haven Hospital, New Haven, CT.

    PURPOSE: In recent years, clinical use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has grown. Extracorporeal circulation is an essential component of heart and lung transplantation,…
  • 2015 American Transplant Congress

    Effects of the Allo-Immune Response On Nerve Regeneration in Vascularized Composite Allotranplantation

    S. Tuffaha,1 J. Budihardjo,1 P. Afrooz,2 K. Sarhane,1 R. Jindal,2 D. Cooney,1 G. Brandacher,1 W. Lee.1

    1Plastic and Reconstructive Surgery, Johns Hopkins Medical Institutions, Baltimore, MD; 2Plastic and Reconstructive Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

    Purpose: Unlike solid organ transplantation, VCA relies on adequate nerve regeneration for graft function. There is a lack of understanding regarding how the alloimmune response…
  • 2015 American Transplant Congress

    Effects of Immunosuppressives On Porcine Renal Microvascular Endothelial Cell–Activated Human T Cell Proliferation: A Cellular Model of Kidney Xenotransplantation In Vitro

    Z.-Y. Wang, M. Tector, S. Nagai, J. Butler, R. Blankenship, S. Downey, J. Estrada, P. Li, A. Tector.

    Surgery, Indiana University School of Medicine, Indianapolis, IN.

    Background: The creation of genetically-modified pigs has brought us closer than ever to clinical xenotransplantation. However, the optimal immunosuppressive doses still need to be established…
  • 2015 American Transplant Congress

    Presence of Donor Leukocytes and Donor MHC-Cross-Dressed Recipient Cells and Its Relationship to Direct T Cell Alloresponses After Allotransplantation

    J. Marino,1 P. Crosby Bertorini,1 M. Uehara,2 J. Paster,1 S. Mordecai,3 W.-H. Liu,1 L. Liu,1 R. Abdi,2 G. Tocco,1 J. Kim,1 J. Markmann,1 G. Benichou.1

    1Surgery Department, Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA; 2Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA; 3Department of Pathology, Flow and Imaging Cytometry Core, Massachusetts General Hospital, Boston, MA.

    We have studied the kinetics of donor cell trafficking from the graft to recipient's lymphoid organs and its correlation to the direct T cell alloresponse…
  • 2015 American Transplant Congress

    mTOR Inhibitors Reduce the Endothelial Transmigration of Leukocytes After Ischemia

    I. Werner, A. Hernandez-Sierra, F. Guo, A. Moritz, A. Beiras-Fernandez.

    Department of Thoracic and Cardiovascular Surgery, University Hospital Frankfurt, Frankfurt am Main, Germany.

    ObjectivemTOR inhibitors Everolimus and Sirolimus are currently used as maintenance immunosuppressive agents to prevent rejection of solid transplanted organs. Episodes of transplant rejection and graft…
  • 2015 American Transplant Congress

    Local Expansion in DCD Kidney Transplant Activity Improves Waiting List Outcomes and Addresses Inequities of Access to Transplantation

    B. Mirshekar-Syahkal,1 L. Bradbury,2 P. Sun,1 M. Aly,1 M. Berry,1 J. Norris,1 J. Bradley,1 G. Pettigrew.1

    1Cambridge University, Cambridge, United Kingdom; 2NHSBT, Bristol, United Kingdom.

    Introduction: Following expansion in our circulatory death (DCD) transplant program, our center now performs twice as many DCD as brain-death (DBD) kidney transplants. Here, we…
  • 2015 American Transplant Congress

    Unknown Urological Pathologies in Renal Allografts from Deceased Donors. Should Image Evaluation Be Routinely Performed?

    K. Yamaçake, W. Nahas, I. Antonopoulos, H. Kanashiro, R. Kato, A. Bull, R. Falci, A. Piovesan.

    Division of Urology, Renal Transplantation Unit, University of Sao Paulo, Sao Paulo, Brazil.

    Purpose: In an effort to increase the overall donor pool, the use of extended-criteria kidneys has been routine in the majority of transplant centers. It…
  • 2015 American Transplant Congress

    Belatacept in a Community Hospital Adult Kidney Transplant Program

    D. Nikolaenko, Q. Chaudhry, H. Smith, C. Shadur.

    Iowa Methodist Medical Center, Des Moines, IA.

    PURPOSE:This is a retrospective look (08/2011-11/2014) on data collected from patients transplanted at Iowa Methodist Transplant Center.METHODS:All patients were EBV positive. They were induced with…
  • 2015 American Transplant Congress

    Epidemiology of Early Post Liver Transplant (LT) Infections 2008-12: Time to Reconsider Perioperative Prophylaxis Regimen?

    K. Doucette, M. Charles, M. Al Dabbagh, J. Preiksaitis.

    Department of Medicine, University of Alberta, Edmonton, AB, Canada.

    Background: The most common pathogens seen in early post LT intraabdominal and bloodstream infection are enterococci, staphylococci and aerobic gram negative bacilli and perioperative prophylaxis…
  • 2015 American Transplant Congress

    Utilizing CDC High Risk Donors to Improve Outcomes in Liver Transplantation

    V. Fleetwood, J. Lusciks, M. Hertl, E. Chan.

    General Surgery, Division of Transplant Surgery, Rush University Medical Center, Chicago, IL.

    Introduction: An under-utilized demographic in liver transplantation is the CDC high-risk donor (HRD). These individuals, considered at higher risk of blood-borne diseases, contribute approximately 9%…
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