Am J Transplant, Volume 5, Suppl 3 Archives - Page 156 of 170 - ATC Abstracts

2015 American Transplant Congress
Epstein Barr Virus Modulates Host Cell MicroRNA-194 to Promote IL-10 Production in B Cell Lymphomas
A. Harris-Arnold, S. Schaffert, O. Hatton, C. Esquivel, S. Krams, O. Martinez.
Surgery/Division of Abdominal Transplant, Stanford University School of Medicine, Stanford, CA.
Epstein Barr virus (EBV) infection is associated with the development of post-transplant lymphoproliferative disorder (PTLD) which can manifest as aggressive B cell lymphomas in transplant…
2015 American Transplant Congress
Allogeneic Mature Human Monocyte-Derived Dendritic Cells Generate Superior Alloreactive Regulatory T Cells in an IL-2-Independent Manner
N. Litjens,¹ K. Boer,¹ J. Zuijderwijk,¹ M. Klepper,¹ A. Peeters,¹ E. Prens,² W. Verschoor,¹ R. Kraaijeveld,¹ Z. Ozgur,³ M. van den Hout-van Vroonhoven,³ W. van IJcken,³ C. Baan,¹ M. Betjes.¹
¹Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands; ²Dermatology and Rheumatology, Erasmus Medical Center, Rotterdam, Netherlands; ³Erasmus Center for Biomics, Erasmus Medical Center, Rotterdam, Netherlands.
IntroductionExpansion of antigen (Ag)-specific natural occurring regulatory T cells (nTregs) is required to obtain sufficient numbers of cells for cellular immunotherapy. In this study, different…
2015 American Transplant Congress
Impact of Delayed Graft Function and Number of Dialysis Sessions on Graft Outcome After Kidney Transplantation
L. Lehner, A. Hohberger, L. Marschke, K. Zhang, F. Halleck, D. Khadzhynov, O. Staeck, M. Dürr, D. Schmidt, L. Liefeldt, K. Budde.
Dep.of Nephrology Charité Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany.
IntroductionDelayed graft function (DGF), defined as dialysis within the first week after kidney transplantation, is a common and known risk factor for impaired renal graft…
2015 American Transplant Congress
T-Cell Mediated Vascular Rejection Can Be Identified By the Combined Measurement of Five Specific microRNAs in Blood
M. Matz,¹ K. Fabritius,¹ C. Lorkowski,¹ M. Dürr,¹ J. Gaedeke,¹ P. Durek,² J. Grün,² A. Goestemeyer,¹ F. Bachmann,¹ K. Wu,¹ B. Rudolph,¹ U. Weber,¹ C. Haftmann,² N. Unterwalder,³ N. Lachmann,¹ A. Radbruch,² H.-H. Neumayer,¹ M.-F. Mashreghi,² K. Budde.¹
¹University Medicine Charité, Berlin, Germany; ²German Rheumatism Research Centre, Berlin, Germany; ³Labor Berlin GmbH, Berlin, Germany.
MicroRNAs hold important roles in the regulation of gene expression. Their function has been correlated with kidney disease and they might represent a new class…
2015 American Transplant Congress
Excellent Outcomes With Deceased Donor Kidney Transplants With a Terminal Creatinine >= 3
L. Matsuoka,¹ E. Alicuben,¹ K. Woo,¹ H. Shidban,¹ Y. Qazi,² M. Smogorzewski,² S. Alexopoulos.¹
¹Department of Surgery, USC Keck School of Medicine, Los Angeles, CA; ²Department of Nephrology, USC Keck School of Medicine, Los Angeles, CA.
Purpose: Kidneys from deceased donors with elevated creatinine are frequently discarded due to concerns about poor post-transplant outcomes. In this study we sought to determine…
2015 American Transplant Congress
Liver Allograft Utilization Within the United States: 2003-2013
J. Renz,¹ G. Diaz,¹ L. Ratner,² H. Yersiz,³ M. Millis,¹ J. Matthews.¹
¹Department of Surgery, University of Chicago, Chicago, IL; ²Department of Anesthesia/Critical Care, University of Chicago, Chicago, IL; ³Department of Surgery, Columbia University, New York, NY; ⁴Department of Surgery, University of California Los Angeles, Los Angeles, CA.
Objectives: 1) Evaluate liver allograft availability, utilization, and failure probability utilizing the liver donor risk index(LDRI) 2) Correlate allograft utilization with waitlist mortality and incidence…
2015 American Transplant Congress
Hypothermic Machine Preservation Reduces Inflammatory, Hypoxic and Apoptotic Injuries in Human Liver Transplantation
J. Guarrera, C. Bae, S. Henry.
Center for Liver Disease and Transplantation, Columbia University Medical Center, New York, NY.
Introduction: Hypothermic machine perfusion (HMP) is in its infancy in Liver Transplantation. We analyzed all molecular samples from our cumulative clinical experience at Columbia University.Methods:…
2015 American Transplant Congress
Interim Results of a Phase 1 Trial of Treg Adoptive Cell Transfer (TRACT) in Living Donor Kidney Transplant Recipients
J. Leventhal,¹ A. LeFever,² A. Skaro,¹ L. Gallon,¹ J. Mathew,¹ D. Stare,¹ I. Konieczna,¹ J. He,¹ G. Johnson.³
¹Northwestern University, Chicago; ²Northwestern Memorial Hospital, Chicago; ³TRACT Therapeutics Inc., Chicago.
Therapeutic cell transfer using regulatory T cells (Tregs) in transplant recipients may reduce the need for drug based immunosuppression (IS) and improve long term graft…
2015 American Transplant Congress
Glucose Chemical Exchange Saturation Transfer MRI of Acute Renal Allograft Rejection
D. Kentrup,¹ A. Busch,² H. Pawelski,¹ V. Hoerr,^2,3 S. Reuter.¹
¹Department of Medicine D, University Hospital Münster, Münster, Germany; ²Department of Clinical Radiology, University Hospital Münster, Münster, Germany; ³Institute of Medical Microbiology, Jena University Hospital, Jena, Germany.
Purpose: During acute rejection episodes large amounts of immune cells infiltrate renal grafts, leading to inflammation accompanied by an increased glucose metabolism.Given these circumstances we…
2015 American Transplant Congress
Evaluation of the Use of Leflunomide for the Prevention of BK Nephropathy in Renal Transplant Recipients- A Single Center Experience
S. Jonchhe, E. Hollinger, S. Jensik, O. Olaitan, A. Hodowanec, M. Hertl, S. Fayek, E. Chan, C. Pullum, N. Alvey.
Rush University Medical Center, Chicago, IL.
Objective: The purpose of this study was to compare the efficacy of leflunomide in combination with reduced immunosuppression versus reduction of immunosuppression alone for the…