2015 American Transplant Congress
Cognate Events in Antibody- Vs. T Cell-Mediated Rejection: A Molecular Perspective
AIM: The cognate event in antibody-mediated rejection (ABMR) is NK cell FcR engagement; T cell mediated rejection (TCMR) uses TCR engagement. Understanding the molecular changes…2015 American Transplant Congress
Validation of Predictive Nomograms for Delayed Graft Function in Kidney Transplant Recipients
Multi-Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Background: Delayed graft function (DGF), defined by the need for dialysis within 7 days after transplantation, impacts short and long term graft outcomes. Predictive nomograms…2015 American Transplant Congress
Age-Dependent Decline in Glomerular Filtration Rate: A US Population-Based Study
Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA.
Background and aim: Reduced renal function is nearly a universal complication experienced by organ transplant recipients, in part related to nephrotoxicity of calcineurin inhibitors. With…2015 American Transplant Congress
Utilization of Increased Risk Donors in a Canadian Multi-Organ Transplant Program
Background: Due to a shortage of organ donors and increasing mortality on the wait list, marginal donors, including those at increased risk for blood borne…2015 American Transplant Congress
Low Dose Valganciclovir Is an Effective Prophylaxis Against Cytomegalovirus in High Risk (Donor+/ Recipient-) Kidney Transplants Recipients
Introduction: Universal prophylaxis against Cytomegalovirus (CMV) disease is endorsed in high risk seronegative kidney (K) transplant (TX) recipients of organs from seropositive donors (D+/R-) using…2015 American Transplant Congress
Changes in Donor Specific Antibodies (DSA) First Year After Kidney Transplant (KTX): Implications for Graft Histology and Survival
Introduction. De novo DSA post-KTx is associated with high risk of chronic antibody mediated rejection (cAMR) and reduced graft survival. DSA changes during first year…2015 American Transplant Congress
The Impact of Therapy On the Inflammatory Infiltrate in Renal Allografts With Acute and Chronic Antibody Mediated Rejection
Little is known about the effect of usual treatment for acute and chronic antibody mediated rejection (aAMR and cAMR) on inflammatory cells within the allograft.…2015 American Transplant Congress
First Clinical Data With an Improved C1q-Luminex® Assay
1Nephrology, Charite Hospital, Berlin, Germany; 2HLA Laboratory, Charite Hospital, Berlin, Germany.
Background: Chronic allograft dysfunction remains the main obstacle for long-term success of kidney transplantation. Immunological factors, in particular HLA-antibodies, contribute to long-term allograft loss. Identification…2015 American Transplant Congress
Alemtuzumab in Elderly Renal Transplant Recipients Is Not Associated With a Poor Outcome
Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, United Kingdom.
The use and choice of induction immunosuppression in elderly kidney recipients remains unresolved. Alemtuzumab has been associated with a higher risk of death and graft…2015 American Transplant Congress
Early Use of Anti-Lymphocyte Antibody in Kidney Transplant Recipients With Delayed Graft Function Can Produce Desirable Post-Transplant Results
Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea.
Proper management of delayed graft function (DGF) is essential for successful post-transplant result in deceased donor kidney transplantation. We compared the effect of anti-lymphocyte antibody…
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