Am J Transplant, Volume 5, Suppl 3 Archives - Page 143 of 170 - ATC Abstracts

2015 American Transplant Congress
Improving ABMR Diagnostics Through Advanced Anti-HLA Antibody Screening Techniques
R. Ponsirenas,^1,2 H. Cazarote,^1,2 S. Shimakura,³ J. Valdameri,¹ F. Contieri,⁴ C. von Glehn,^1,2 M. Susin.^1,2
¹Transplant Immunology Laboratory, Pontifícia Universidade Católica do Paraná, Curitiba, Parana, Brazil; ²Medicine School, Pontifícia Universidade Católica do Paraná, Curitiba, Parana, Brazil; ³Departament of Statistics, Universidade Federal do Parana, Curitiba, Parana, Brazil; ⁴Kidney Transplant Unit, Hospital Evangélico de Curitiba, Curitiba, Parana, Brazil.
The identification of low-level antibodies by single antigen bead methodology has brought advancements in risk evaluation of kidney transplants recipients. However, the use of the…
2015 American Transplant Congress
Kidney Transplantation (KTx) With Positive Crossmatch (XM) but No Donor Specific Antibody (DSA)
J. Verbesey, O. Timofeeva, L. Dong, B. Javaid, G. Monica, A. Gilbert, J. Moore, P. Weems, S. Ghasemian, S. Rosen-Bronson, M. Cooper.
MedStar Georgetown Transplant Institute, Washington, DC.
Purpose: Prior to KTx, a XM is performed between the intended recipient and donor. This XM can be positive despite no DSA. It can be…
2015 American Transplant Congress
Novel Flow Cytometry Method for Detecting Complement-Fixing Blood Group IgG Antibody in ABO-Incompatible Renal Transplantation
T. Ishizuka,¹ M. Yasuo,¹ Y. Ishida,¹ H. Miura,¹ K. Iwadoh,² T. Murakami,² K. Kitajima,² I. Nakajima,² S. Fuchinoue.²
¹Transplant Immunology, Tokyo Women's Medical University, Shinjuku ward, Tokyo, Japan; ²Surgery III, Tokyo Women's Medical University, Shinjuku ward, Tokyo, Japan.
【Background】We experienced a hyperacute rejection (HAR) in ABO-incompatible renal transplantation (ABO-I RTx) on POD 0. We hypothesized that complement-fixing IgG anti-A/B blood group antibody (anti-A/B…
2015 American Transplant Congress
Immune-Mediated Injury in Kidney Transplant Recipients Treated With Alemtuzumab Induction and a Steroid Avoidance Protocol
R. Sapir-Pichhadze, T. Mahbub, C. Saw, D. Baran.
McGill University Health Centre, Montreal, Canada.
Study purpose: We evaluated short-term clinical and immunological outcomes of kidney transplant recipients who received alemtuzumab induction and a steroid-avoidance protocol.Methods: This is a retrospective…
2015 American Transplant Congress
Clinical Consequences of Immune-Mediated Allograft Arteriosclerosis: A Population Based Study
A. Loupy, Vernerey, Viglietti, Aubert, Duong van Huyen, Bruneval, Empana, Suberbielle, Glotz, Jouven, Legendre, Lefaucheur.
Paris Translational Research Center for organ Transplantation, Paris, France.
BACKGROUNDThe role of circulating antibodies and alloimmune response beyond traditional cardiovascular risk factors in the development of accelerated arteriosclerosis and its long-term clinical consequences is…
2015 American Transplant Congress
Serial Changes in Body Composition After Kidney Transplantation
S. Deger,¹ A. Bian,² G. Chen,² T. Ikizler,¹ K. Birdwell.¹
¹Medicine, Vanderbilt University Medical Center, Nashville, TN; ²Biostatistics, Vanderbilt University Medical Center, Nashville, TN.
BACKGROUND: A significant long-term nutritional problem after kidney transplantation is obesity. We examined the changes in body composition after transplantation and its determinants.METHODS: A total…
2015 American Transplant Congress
End of Treatment Liver Biopsy With Sofosbuvir: Histologic Changes Suggestive of Hepatitis C Activity in Liver Transplant Recipients With Achieved SVR
B. Ismail,¹ X. Zervos,¹ P. Bejarano,² M. Waton,¹ D. Beltran,³ D. Sears,¹ A. Tzakis.¹
¹Liver Transplant, Cleveland Clinic Florida, Weston, FL; ²Pathology, Cleveland Clinic Florida, Weston, FL; ³Pharmacy, Cleveland Clinic Florida, Weston, FL.
Background: Interferon (IFN) free HCV regimens are associated with better tolerability and efficacy. The majority of studies report biochemical and virological response; however limited information…
2015 American Transplant Congress
Does Smoking Lead to Increased Rates of Acute Cellular Rejection in Liver Transplant Recipients?
B. Rao,¹ D. Montezuma-Calvo,² K. Tosch,² S.-M. Jafri.²
¹Internal Medicine, Henry Ford Hospital, Detroit, MI; ²Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI.
Introduction: Prior studies of liver transplant recipients who smoke have shown associations between mortality and adverse outcomes. We investigated if smoking status at the time…
2015 American Transplant Congress
Trends in Transplant Patient Safety Situation Reporting
T. Daly,¹ H. Neil,² D. Stewart,² S. Tlusty,² A. Harper,² D. Marshman,³ M. Green.⁴
¹NY-Presbyterian Hosp., New York, NY; ²UNOS, Richmond, VA; ³LifeNet Health, Roanoke, VA; ⁴Children's Hosp. of Pittsburgh, Pittsburgh, PA.
Background: The OPTN Operations & Safety Committee is charged with reviewing aggregated, de-identified safety situation data reported through both the UNet Improving Patient Safety (IPS)…
2015 American Transplant Congress
DNA Methytransferase 1 Inhibition Potently Suppresses T Cell Cycle Progression Through Demethylation of the Key Cell Cycle Inhibitors p15, p16, p21 and p27
T. Ma, Y. Pei, R. Tao.
Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China.
Background: Epigenetic mechanisms like acetylation and methylation have been gradually appreciated to play a critical role in the generation and function of various immune cells.…