ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Correlation Between C3d-Binding De Novo Donor Specific HLA Antibodies and Rejection in Kidney Transplant Recipients

    M. Cusick, K. Haarberg, J. Friedewald, A. Tambur.

    Comprehensive Transplant Center, Northwestern University, Chicago, IL.

    Donor specific antibodies (DSA) directed against HLA arising de novo post-kidney transplant are a major cause of graft loss, termed antibody mediated rejection (AMR). Currently,…
  • 2015 American Transplant Congress

    Preformed Anti-HLA DP Donor Specific Antibodies Are Clinically Significant in Renal Transplantation

    V. Dibbur, M. Willicombe, P. Brookes, R. Sergeant, A. Wardle, D. Taube.

    Renal and Transplant Medicine, Imperial Healthcare NHS Trust, London, United Kingdom.

    Background: Whilst preformed [PF] anti-HLA A, B, DR and DQ donor specific antibodies [DSAbs] are associated with poorer allograft outcomes secondary to antibody mediated injury,…
  • 2015 American Transplant Congress

    Octogenarian Kidney Transplant Recipients: A Single Center Experience

    B. Ravichandran, T. Sparkes, B. Thomas, F. Rasetto, M. Gillespie, M. Moss, S. Bartlett, B. Masters.

    University of Maryland Medical Center, Baltimore, MD.

    Background: Elderly patients are the fastest growing population requiring kidney transplantation internationally. Previous studies have shown a survival benefit for kidney transplantation when compared to…
  • 2015 American Transplant Congress

    Induction With an Interleukin-2 Receptor Antagonist in Sensitized Adult Kidney Transplant Recipients Is Highly Effective and Safe

    J. Casale, J. Fleming, D. Taber, C. Staino, K. Boyle, K. Covert, N. Pilch, H. Meadows, C. Mardis, K. Chavin, C. Bratton, J. McGillicuddy, P. Baliga.

    MUSC, Charleston, SC.

    Background: The effectiveness and safety of induction with basiliximab (IL2RA) in sensitized kidney transplant recipients is not clearly established. The aim of this study was…
  • 2015 American Transplant Congress

    Negative Exercise Myocardial Perfusion Scintigraphy Discards Silent Coronary Artery Disease in High Cardiovascular Risk Patients Awaiting for Kidney Transplantation

    E. Melilli,1 V. Navarro,2 O. Bestard,1 A. Gomez,3 J. Cruzado.1

    1Kidney Transplantation Unit, Hospital de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain; 2Nephrology Service, Hospital San Juan de Dios, San Jose, Costa Rica; 3Cardiac Intensive Care Unit, Hospital de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

    Study Purpose:Screening for silent coronary artery disease (SCAD) in patients awaiting kidney transplantation is still controversial. Indeed, guidelines of some scientific societies show important discrepancies.…
  • 2015 American Transplant Congress

    Impact of Proton Pomp Inhibitors on Hypomagnesemia and Arterial Stiffness in Renal Transplant Recipients

    S. Sezer,1 B. Gurlek Demirci,1 M. Erkmen Uyar,1 S. Uyanik,2 M. Haberal.3

    1Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey; 2Department of Intrenal Medicine, Baskent University Faculty of Medicine, Ankara, Turkey; 3Department of General Surgery, Baskent University Faculty of Medicine, Ankara, Turkey.

    Purpose: Hypomagnesemia predicts cardiovascular morbidity and mortality in the general population and accelerated loss of kidney function in renal transplant recipients (RTRs). Proton pomp inhibitors…
  • 2015 American Transplant Congress

    The Effect of Preformed and De Novo Donor-Specific Antibodies (DSA) in Acute Rejection (AR) After Liver Transplantation (LTX)

    M. Koch,1 M. Runnebaum,1 M. Goebel,2 H. Thude,1 M. Sterneck,1 M. Marget,2 B. Nashan.1

    1Hepatobiliary Surgery and Transplantation, University Medical Centre, Hamburg, Germany; 2HLA-Laboratory, University Medical Centre, Hamburg, Germany.

    BACKGROUND: The role of preformed and den novo formed DSA in LTX is not fully revealed. The aim of our study was to determine if…
  • 2015 American Transplant Congress

    Graft-Versus-Host Disease After Orthotopic Liver Transplantation: Multivariate Analysis of Risk Factors

    M. Elfeki, P. Genco, S. Pungpapong, J. Nguyen, D. Harnois.

    Transplantation, Mayo Clinic, Jacksonville, FL; Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL.

    Introduction:Acute graft versus host disease (GVHD) is a rare fatal complication following orthotopic liver transplantation (OLT). It involves activation of donor T lymphocytes by antigen…
  • 2015 American Transplant Congress

    Effect of 2007 CMS Conditions of Participation on High Risk Renal Transplantation: A Study of the United States Renal Data System

    D. John, A. Brar, F. Tedla, N. Sumrani, E. Timpo, M. Salifu.

    Division of Transplantation, SUNY Downstate Medical Center, Brooklyn, NY.

    BACKGROUND: On June 28, 2007, CMS introduced new Conditions of Participation (CoP) for Transplant Centers- the impact of these regulations on adult patients at high…
  • 2015 American Transplant Congress

    Aging Enhances Immunosuppressives Capacities of Tacrolimus By Functional Changes of CD4+ T-Cells

    F. Krenzien,1 M. Quante,1 A. ElKhal,1 H. Uehara,1 R. Abdi,2 B. Slegtenhorst,1 H. Biefer,1 S. Tullius.1

    1Transplant Surgery Research Laboratory and Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; 2Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

    Immunosenescence has broad consequences on alloimmunity and immunosuppression in the elderly may require age-adaptation. Here, we investigated the influence of aging on the effectivity of…
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