2015 American Transplant Congress
Everolimus Initiation Immediately After Liver Transplantation: A Single-Center Experience
University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
BackgroundClinical trials in liver transplant (LTX) patients with randomization on day 30 to everolimus (EVR) show a benefit in renal function compared to calcineurin inhibitor…2015 American Transplant Congress
Elevated Cancer Risk Among US Pediatric Solid Organ Transplant Recipients
Among pediatric transplant recipients, the effects of transplantation and immunosuppression on cancer risk may be unique from those observed in the adult transplant population. No…2015 American Transplant Congress
Donor and Recipient Pretransplant Polyoma BK Serostatus: Relationship to BK-Viremia After Renal Transplantation
Surgery, Albany Medical College, Albany, NY.
Background:Polyoma virus BK nephropathy is a serious complication after renal transplantation and is associated with a significant risk of graft loss and dysfunction. This study…2015 American Transplant Congress
Patient Outcomes After Listing for Kidney Alone Transplantation in Potential Recipients Aged Over 70 Years
BackgroundLow likelihood of listing and subsequent deceased donor transplantation has previously been reported for the elderly with additional concerns about patient frailty, morbidity and mortality…2015 American Transplant Congress
Sevoflurane Based Anesthesia in Recipients Reduces 2 Year Acute Rejection in Living Donor Kidney Transplantation. Results from the VAPOR-Trial
IntroductionVolatile anesthetic agents like sevoflurane may protect against the ischemia and reperfusion injury (IRI) that is inevitable part of organ donation and transplantation. It is…2015 American Transplant Congress
Recipient IL-33 Promotes Type 1 Alloimmunity and Lethal Acute GVHD Following alloHCT
Background: Graft-versus-host disease (GVHD) is a common complication of allogeneic (allo) hematopoietic cell transplantation (HCT) that limits its widespread application for the induction of transplant…2015 American Transplant Congress
Impact of Human Mutant TGF-β1/Fc Protein On Memory and Regulatory CD4+T Cells Following Lymphodepletion in Rhesus Monkeys
Background:Tolerance to allografts is essential to avoid chronic immunosuppression and to promote long term graft function. Transforming growth factor- β plays a key role in…2015 American Transplant Congress
Donor Organ Resident M2 Type Myeloid Cells Protect Murine Orthotropic Liver Transplants from Ischemia and Reperfusion Injury
The Dumont-UCLA Transplant Ctr., UCLA, Los Angeles, CA.
Liver ischemia reperfusion injury (lRI) is mediated by a pro-inflammatory immune response initiated by the activation of liver non-parenchymal innate immune cells, such as Kupffer…2015 American Transplant Congress
Monocyte Recruitment to HLA Class I Antibody-Activated Endothelial Cells Is Dependent Upon mTOR
Pathology & Laboratory Medicine, UCLA, Los Angeles, CA.
Aim: Antibody-mediated rejection (AMR) persists as a major issue affecting solid organ transplants. The purpose of this study was to investigate the proximal signaling events…2015 American Transplant Congress
Cognate Events in Antibody- Vs. T Cell-Mediated Rejection: A Molecular Perspective
AIM: The cognate event in antibody-mediated rejection (ABMR) is NK cell FcR engagement; T cell mediated rejection (TCMR) uses TCR engagement. Understanding the molecular changes…
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