Am J Transplant, Volume 5, Suppl 3 Archives - Page 137 of 170 - ATC Abstracts

2015 American Transplant Congress
DNA Methylation of the IFNγ Promoter in CD8+ T Cell Subsets Is Modulated by CMV Infection but not by Alloreactivity in Kidney Transplantation Patients
K. Boer,¹ E. de Wit,¹ L. Hofland,² M. Betjes,¹ C. Baan.¹
¹Internal Medicine - Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, Netherlands; ²Internal Medicine - Endocrinology, Erasmus University Medical Center, Rotterdam, Netherlands.
Introduction DNA methylation plays a critical role in the function of cells, including cells of the immune system. Little is known about the methylation status…
2015 American Transplant Congress
Frequencies of CD4⁺25^hiFoxp3⁺T Cells in Long-Term Follow-Up of Sirolimus-Converted Kidney Transplant Recipients
O. Traitanon,^1,2 A. Alvarado,¹ E. Tantisattamo,^1,2 A. Shetty,^1,2 M. Ansari,^1,2 J. Mathew,¹ J. Leventhal,¹ V. Mas,³ L. Gallon.^1,2
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²Medicine-Nephrology, Northwestern University, Chicago, IL; ³Surgery, University of Virginia, Charlottesville, VA.
Background: Tacrolimus(TAC) and Sirolimus(SRL) are commonly used immunosuppressive drugs in kidney transplantation. SRL has been shown to induce the expansion of regulatory T cells in…
2015 American Transplant Congress
Development and Validation of a Genotype Guided Tacrolimus Dosing Equation for African American (AA) Kidney Transplant Recipients
K. Sanghavi,¹ R. Brundage,¹ M. Miller,² D. Schaldt,³ A. Israni,³ W. Guan,⁴ W. Oetting,¹ R. Mannon,⁵ R. Remmel,¹ A. Matas,⁶ P. Jacobson.¹
¹College of Pharmacy, University of MN, Minneapolis, MN; ²Dept of Psychology, University of MN, Minneapolis, MN; ³Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; ⁴Dept of Biostatistics, University of MN, Minneapolis, MN; ⁵Dept of Nephrology, University of AL, Birmingham, AL; ⁶Dept of Surgery, University of MN, Minneapolis, MN.
Tacrolimus (tac) has a strong exposure-response relationship with high inter-individual variability in troughs and dose. Tac dose requirements for AA patients are higher than Caucasians,…
2015 American Transplant Congress
CMV prevalence in Mauritian and Indonesian Cynomolgus Macaques: Significance in Transplantation and CMV Disease Models
K. Premanand,¹ E. Szilagyi,¹ J. Yu,¹ R. Patel,¹ A. Antony,¹ M. Willman,² D. Berman-Weinberg,² D. Han,² A. Vaidya,³ E. Silva,³ K. McHenry,³ D. Salomon,⁴ N. Kenyon,² A. Bartholomew.¹
¹University of Illinois, Chicago; ²Univerisity of Miami, Miami; ³University of Illinois, Urbana; ⁴Scripps, San Diego.
Despite the finding that most macaques express high serologic titers of anti-CMV antibody, susceptibility to disease appears to be variable post-transplant. This observation led us…
2015 American Transplant Congress
T Cell Specific Up Regulation of Nrf2 Regulated Antioxidant Response Protects from Kidney Ischemia Reperfusion Injury in Mice
S. Noel,¹ M. Martina,² S. Bandapalle,¹ S. Reddy,³ L. Racusen,² A. Hamad,² H. Rabb.¹
¹Department of Medicine, Johns Hopkins University, Baltimore, MD; ²Department of Pathology, Johns Hopkins University, Baltimore, MD; ³Department of Pediatrics, University of Illinois, Chicago, IL.
Background: T lymphocytes mediate important pathophysiological roles during ischemia reperfusion injury (IRI). Transcription factor Nrf2 is protective during experimental kidney IRI and thought to be…
2015 American Transplant Congress
Cross-Linking of MHC Class I Induces Unique Transcriptional Profiles Associated With Regulation of Both T and B Cells That Precedes Induction of Allo- and Auto-Immunity Leading to Obliterative Airway Disease
D. Nayak, M. Sharma, Z. Xu, A. Gelman, T. Mohanakumar.
Surgery, Washington Univ Sch of Med, St. Louis, MO.
Background: Incidences of chronic rejection, bronchiolitis obliterans syndrome (BOS), remain a major challenge to lung transplantation and development of allo- and auto-immunity has been proposed…
2015 American Transplant Congress
Pregnancy After Renal Transplantation: Unfavorable Outcomes in Sensitized Patients
M. Ajaimy, M. Lubetzky, L. Kamal, G. De Bocardo, E. Akalin.
Einstein/Montefiore Transplant Center, Bronx.
Background: The objective of our study was to describe pregnancy and allograft outcomes in sensitized kidney recipients in a predominantly Hispanic and African-American population.Methods: This…
2015 American Transplant Congress
Intermittent High Dose Intravenous Immunoglobulin as Treatment for Donor Specific Antibodies in Renal Transplant Recipients
P. Bolin,¹ K. Parker,² F. Rana,¹ W. Bryant,¹ P. Jawa,¹ R. Harland.³
¹Internal Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; ²Vidant Medical Center, Greenville, NC; ³Surgical Immunology and Transplantation, East Carolina University, Brody School of Medicine, Greenville, NC.
Background: Donor-specific HLA antibody (DSA) formation in post-renal transplant patients is associated with chronic rejection and graft failure. Previous studies in our population have indicated…
2015 American Transplant Congress
A Specific Inhibitor of C1s, TNT003, Prevents Complement-Mediated Enhancement of Monocyte Adhesion to Endothelium in Response to HLA Antibodies
N. Valenzuela,¹ K. Thomas,¹ A. Mulder,² G. Parry,³ S. Parker,³ E. Reed.¹
¹Immunogenetics Center, UCLA, Los Angeles, CA; ²Leiden University, Leiden, Netherlands; ³True North Therapeutics, San Francisco, CA.
HLA antibody (Ab) mediated complement activation on endothelial cells (EC) is likely a critical driver of antibody-mediated inflammation. Production of complement anaphylatoxins by HLA antibodies…
2015 American Transplant Congress
Neogenin Functions as a Chemokinetic Receptor on Activated CD4+ T Lymphocytes
L. Boneschansker,¹ H. Nakayama,¹ M. Eisenga,¹ M. Klagsbrun,¹ D. Irimia,² D. Briscoe.¹
¹Boston Children's Hospital, Boston; ²Massachusetts General Hospital, Boston.
Increasing data indicates that axonal guidance cues play a critical role in immunity, both in activation, migration as well as in the process of inflammation…