Am J Transplant, Volume 5, Suppl 3 Archives - Page 13 of 170 - ATC Abstracts

2015 American Transplant Congress
Hydrogen Sulfide Restores Protective Capacity of University of Wisconsin Solution During Normothermic Preservation
J. Grewal,¹ I. Lobb,¹ M. Whiteman,³ A. Sener.^1,2
¹Microbiology & Immunology, University of Western Ontario, London, ON, Canada; ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ³Experimental Therapeutics, University of Exeter Medical School, Exeter, England, United Kingdom.
Organ preservation solution is crucial in mitigating effects of ischemia reperfusion injury (IRI) associated with transplantation. Although University of Wisconsin (UW) solution is ideally suited…
2015 American Transplant Congress
A Common Gene Signature Across Multiple Studies Identifies Biomarkers and Functional Regulation in Tolerance to Renal Allograft
D. Baron,^1,2,3 G. Ramstein,⁴ M. Chesneau,^1,2,3 Y. Echasseriau,^1,2,3 A. Pallier,^1,2,3 C. Paul,^1,2,3 N. Degauque,^1,2,3 M. Hernandez-Fuentes,⁵ A. Sanchez-Fueyo,⁶ K. Newell,⁷ M. Giral,^1,2,3 J.-P. Soulillou,^1,2,3 R. Houlgatte,^8,9 S. Brouard.^1,2,3
¹UMR 1064 - CRTI, INSERM, Nantes, Loire Atlantique (44), France; ²ITUN, CHU de Nantes, Nantes, Loire Atlantique (44), France; ³Faculté de Médecine, Université de Nantes, Nantes, Loire Atlantique (44), France; ⁴UMR 6241 - LINA, Université de Nantes, Nantes, Loire Atlantique (44), France; ⁵MRC Centre for Transplantation, King's College London, London, United Kingdom; ⁶Institute of Liver Studies, King's College Hospital, London, United Kingdom; ⁷Department of Surgery, Emory University, Atlanta, GA; ⁸U954 - LNGERE, INSERM, Nancy, France; ⁹DRCI, CHU de Nancy, Nancy, France.
Patients tolerant to a kidney graft display a specific blood transcriptional pattern but reported results from five distinct studies hardly overlapped, raising the question of…
2015 American Transplant Congress
TIM-4 Identifies IL-17 Expressing Pro-Inflammatory Be-17 Cells That Promote Allograft Rejection
Q. Ding, K. Mohib, D. Rothstein.
Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.
We identified TIM-1 as an inclusive marker for IL-10+ regulatory B cells (TIM-1+ Bregs), which prolong islet allograft survival (GS). We recently found that TIM-4,…
2015 American Transplant Congress
Socioeconomic Status of Local Vs Exported Liver Recipients and Their Donors
J. Adler,¹ J. Hyder,² J. Markmann,¹ H. Yeh.¹
¹Massachusetts General Hospital, Boston, MA; ²Mayo Clinic, Rochester, MN.
INTRODUCTION: Broader sharing has been proposed as a solution to decrease geographic disparities in liver transplantation, with the hope that this will also neutralize the…
2015 American Transplant Congress
Regulatory T Cells Expanded by Activated iNKT Cells Facilitate Migration of Donor Dendritic Cells Into the Recipient Thymus and Subsequent Establishment of Clonal Deletion
T. Hirai,¹ R. Shibahara,¹ S. Miyairi,¹ M. Ikemiyagi,¹ K. Omoto,¹ Y. Ishii,² K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Laboratory for Vaccine Design, RINEK Center for IMS, Yokohama, Japan.
We previously reported that combination therapy using liposomal α-galactosylceramide (lipo-αGC) and anti-CD154 mAb could expand regulatory T cells (Tregs) in vivo through activation of the…
2015 American Transplant Congress
Risk of Cause-Specific ESRD in Live Kidney Donors
S. Anjum, A. Muzaale, A. Massie, S. Bae, D. Segev.
Johns Hopkins, Baltimore.
The purpose of this study is to investigate the risk of developing cause-specific ESRD in live kidney donors over time.METHODS: We studied a cohort of…
2015 American Transplant Congress
Pretransplant Elevated Plasma Fibrinogen Level Is Associated With Tumor Recurrence and Poor Prognosis in Hepatocellular Carcinoma Patients After Liver Transplantation
G.-Y. Wang, Y. Yang, H. Li, S.-H. Yi, G.-H. Chen.
Department of Hepatic Surgery and Liver Transplant Center, Third Affiliated Hospital, Sun Yat-sen University, Organ Transplantation Institution of Sun Yat-sen University, Guangzhou, China.
Background and Objective: Elevated plasma fibrinogen (FBG) level is associated with tumor progression and poor patient outcomes in several cancers. The aim of this study…
2015 American Transplant Congress
In Vitro Evidence That CTLA4Ig Attenuates Recall Alloantibody Responses
I. Kim,¹ G. Wu,¹ N.-N. Chai,¹ S. Jordan,² A. Klein.¹
¹Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA; ²Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: CTLA4Ig is an agonist that blocks CD28-B7 costimulation, downregulating T cell immunity, but also appears to negate T cell-dependent B cell activation, thus inhibiting…
2015 American Transplant Congress
Clinically Relevant Anti-TCR mAb Induction Plus Brief Rapamycin Therapy Can Achieve Long-Term Vascularized Composite Allograft (VCA) Survival
L. Wang, A. Samanta, J. Huang, T. Bhatti, Z. Wang, R. Han, L. Levin, M. Levine, W. Hancock.
CHOP/UPenn, Philadelphia.
Aim: Current strategies for management of VCA recipients are adapted from solid organ transplant protocols, and almost universally employ induction therapy followed by maintenance triple…
2015 American Transplant Congress
CD3+CD4+ROR gamma t+ TH17 Cells Do Not Play a Critical Role in Islet Allograft Rejection
M. Koulmanda, Z. Fan.
Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA.
We have developed a “color-coded” adoptive transfer model for T cell subset identification that enables serial analysis of islet allograft infiltrating yellow induced regulatory T…