2015 American Transplant Congress
Rational Development of Alloantigen Specific Regulatory T Cell Therapy Requires Insight Into Longevity of Alloimmune Pathways
University of Cambridge, Cambridge, United Kingdom.
IntroductionWe have recently demonstrated that indirect-pathway responses against different alloantigens differ in their strength and longevity; specifically, that indirect responses against MHC class I alloantigen…2015 American Transplant Congress
The Forgotten Cell: Renal Fibroblasts Are Activated By Anti-MHC Class I Antibody
Medicine and Surgery, University of Alabama at Birmingham, Birmingham, AL.
Chronic antibody-mediated (CAMR) rejection remains a major obstacle in the long term survival of kidney transplants, and is associated in part with interstitial fibrosis (IF)…2015 American Transplant Congress
Ischemic Cholangiopathy Following Liver Transplantation from Donation After Circulatory Death Donors: Role of Tissue Plasminogen Activator Flush
Background: Formation of microthrombi within the peribiliary arterial plexus causing necrosis of biliary epithelium may be responsible for ischemic cholangiopathy (IC) after donation after circulatory…2015 American Transplant Congress
Predicting Survival of Deceased Donor Kidneys from Children Under Ten
University of Chicago, Chicago, IL.
Background: The United Network for Organ Sharing (UNOS) has adopted a new allocation algorithm that uses a Kidney Donor Profile Index (KDPI) based on 10…2015 American Transplant Congress
Final Results from the BENEFIT-EXT Trial: A 7 Year Follow-Up of Belatacept Treated Patients
Background: At 3 and 5yrs post-transplant, BENEFIT-EXT showed a renal function benefit and consistent safety in belatacept (bela) treated pts vs cyclosporine (CsA). Final 7…2015 American Transplant Congress
Eomes-Expressing CD8+ T Cells and Th17 Cells Mediate Costimulatory Blockade-Resistant Allograft Rejection in Mice
The etiology of costimulatory blockade-resistant allograft rejection remains unclear. Therefore, the purpose of this study was to evaluate the responsiveness of distinct CD4+ and CD8+…2015 American Transplant Congress
A Gene Expression Assessment for Improving Disease Activity and Stage in Heart ABMR
Paris Transplant Group & ATAGC, Paris - Edmonton, France.
BackgroundABMR is a major cause of heart transplant failure. The diagnosis of ABMR in heart transplantation is based on the 2013 ISHLT pAMR classification. We…2015 American Transplant Congress
Gender Disparity in Infections After Kidney Transplantation
BACKGROUND: Female gender has been suggested as a risk factor for infection after kidney transplant (KT). Preliminary studies have reported that sex hormones such as…2015 American Transplant Congress
Pre-Transplant Donor Specific Antibody With Negative Flow-Crossmatch Was Related to Higher Acute Rejection But Not to Poor Graft Survival
Background: DSA have been associated to lower graft survival and a higher humoral rejection rate, but there is a concern about the clinical impact of…2015 American Transplant Congress
Morphometric Age as a Predictor of Survival Following Kidney Transplantation
1University of Michigan, Ann Arbor, MI; 2Case Western Reserve University, Cleveland, OH.
INTRODUCTION: Better measures of pre-operative risk stratification are needed in kidney transplantation. Analytic morphomics, which utilizes pre-operative imaging, has been shown to objectively assess mortality…
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