2015 American Transplant Congress
Quantifying the Survival Benefit of HLA-Incompatible Kidney Transplantation: A Multi-Center Study
Surgery, Hopkins, Baltimore, MD.
A single center study has demonstrated a two-fold survival benefit of incompatible live donor kidney transplant (ILDKT) compared to remaining on dialysis. We sought to…2015 American Transplant Congress
Short- and Long-Term Outcomes of Mycophenolate Versus Azathioprine in a Large Cohort of Renal Transplant Recipients
1Barnes-Jewish Hospital, St. Louis; 2Washington University School of Medicine, St. Louis.
Purpose: Early studies comparing mycophenolate mofetil (MMF) to azathioprine (AZA) post-renal transplantation demonstrated superiority of MMF over AZA for the prevention of acute rejection (AR).…2015 American Transplant Congress
Post-Liver Transplant Metabolic Syndrome Increases the Risk of Recurrent Fibrosis in Patients With Hepatitis C
Department of Medicine, Columbia University, New York, NY.
Introduction: Post-liver transplant (LT) metabolic syndrome (MS) is common and may impact fibrosis progression in LT recipients with hepatitis C virus (HCV). Methods: All adults…2015 American Transplant Congress
Repurposing Jak/STAT Signaling Inhibition to Enhance Costimulation Blockade and Promote Transplant Acceptance
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore.
PURPOSE: Transplant tolerance induction through conventional costimulation blockade (CoB) remains an elusive goal. Recent evidence suggests that inflammatory cytokines contribute to the activation of alloreactive…2015 American Transplant Congress
Allogeneic Monocyte–Endothelial Cell Interaction Plays a Critical Role in Initiating Early Pro-Fibrosis Responses
Surgery, Duke University Medical Center, Durham, NC.
Chronic allograft nephropathy (CAN), characterized by interstitial fibrosis, vascular intimal thickening, and glomerulosclerosis, has remained as leading cause of allograft failure. The role of innate…2015 American Transplant Congress
Functional Decline in Liver Transplant Candidates: Results from the Functional Assessment in Liver Transplantation (FrAILT) Study
Background: Cirrhosis is characterized by sarcopenia and malnutrition, leading to progressive functional decline. No studies have objectively measured physical functional decline in cirrhotics awaiting liver…2015 American Transplant Congress
Effectiveness of Protocol-Driven Induction Therapy in Adult Kidney Transplant Recipients
Background: Induction therapy significantly improves graft outcomes in kidney transplantation, but the optimal agent based on patient characteristics and immunologic risk is unknown. While many…2015 American Transplant Congress
Evaluation of Donor-Specific Antibodies Through 7 Years With Belatacept in BENEFIT and BENEFIT-EXT
1Emory University, Atlanta; 2Bristol-Myers Squibb, Lawrenceville.
Purpose: The development of donor-specific antibody (DSA) is linked to an increased risk of antibody-mediated rejection and graft failure. The 3 year intent-to-treat results from…2015 American Transplant Congress
Enhanced Requirement for TNF Signaling on Low Affinity Memory CD8+ T Cells During Heterologous Immunity
Heterologous immunity, defined as a process during which microbe-specific T cells cross-react with allogeneic antigen and mediate graft rejection, is recognized as a significant barrier…2015 American Transplant Congress
Survival Benefit of Kidney Transplant Among HIV+ Waitlist Candidates
Chronic diseases, such as end-stage renal disease (ESRD), are now the leading causes of death among HIV+ patients. Multiple studies have demonstrated the efficacy of…
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