Am J Transplant, Volume 5, Suppl 3 Archives - Page 126 of 170 - ATC Abstracts

2015 American Transplant Congress
Donor Lung Preservation With the Organ Care System® Promotes a Tissue Protective and Anti-Inflammatory Response During Transplantation
B. Wiegmann,¹ C. Falk,² M. Seyda,² C. Neudörfl,² A. Akhdar,² C. Kühn,¹ I. Tudorache,¹ M. Avsar,¹ A. Haverich,¹ G. Warnecke.¹
¹Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
ObjectivesWithin INSPIRE trial standard cold storage (SOC) is compared to normothermic, ventilated donor lung preservation (Organ-Care-System®, OCS). As lung preservation may influence immune mediators (IM),…
2015 American Transplant Congress
The Association of Systemic Indoleamine 2,3 Dioxygenase (IDO) Activity Simultaneous With Chronic Rejection On Allograft Kidney Biopsy
V. Dharnidharka, L. Hesemann, J. Mitsios, H. O'Gorman, M. Gunasekaran, D. Dietzen, T. Mohanakumar.
Washington University School of Medicine, St Louis.
Introduction: Previous studies from our group have shown that activity of the biomarker enzyme IDO elevates prior to acute rejection in kidney transplant recipients, as…
2015 American Transplant Congress
Allo-Stimulated Interferon-γ Release and Natural Killer Cell Function Defines and Risk Stratifies Cancer Development in Kidney Transplant Recipients Who Have Cancer Post-transplantation
C. Hope,^1,2 A. Fuss,^1,2 W. Hanf,¹ P. Coates,^1,2 P. Heeger,³ R. Carroll.^1,2
¹The Centre for Clinical and Experimental Transplantation (CCET), Central Northern Adelaide Renal and Transplantation Services (CNARTS), Adelaide, South Australia, Australia; ²Medicine, The University of Adelaide, Adelaide, South Australia, Australia; ³Icahn School of Medicine, The Recanati-Miller Transplant Institute, New York City, NY.
Reducing immunosuppression is efficacious in primary prevention of cancer in Kidney Transplant Recipients (KTR) but can precipitate graft rejection. Conventional immunosuppressive drug monitoring fails to…
2015 American Transplant Congress
Anti-BTLA Antibody (6B2) Induced Prolongation of Fully MHC-Mismatched Murine Cardiac Allograft and Generation of Foxp3+ Regulatory T Cells
M. Uchiyama,^1,2,3 E. Yin,^3,4 X. Jin,^3,5 T. Shimokawa,¹ H. Yagita,² M. Niimi.³
¹Cardiovascular Surgery, Teikyo University, Tokyo, Japan; ²Immunology, Juntendo University Hospital, Tokyo, Japan; ³Surgery, Teikyo University, Tokyo, Japan; ⁴Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; ⁵Cardiovascular and Thoracic Surgery, The 4th Affiliated Hospital of Harbin Medical University, Harbin, China.
Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
2015 American Transplant Congress
Identification of Mouse Tolerogenic B Cells Expressing PD-L1/PD-L2 in B-1a Subset
T. Hirose,^1,2 Y. Tanaka,¹ H. Sakai,¹ Y. Sasaki,¹ H. Ohdan.¹
¹Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan; ²Renal and Genitourinary Surgery, Hokkaido University, Sapporo, Hokkaido, Japan.
Donor lymphocyte infusion (DLI) has been shown to induce donor-specific hyporesponsiveness or even immune-tolerance among alloreactive T cells in different organ transplantation models. However, the…
2015 American Transplant Congress
South Asians Have a Higher Risk of PTDM and Death After Renal Transplantation
D.-A. Moutzouris, L. Kozia, M. Willicombe, R. Corbett, N. Duncan, J. Galliford, A. McLean, D. Taube.
Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, United Kingdom.
South Asians (SA) have a higher risk for cardiovascular disease and diabetes than the general population, but in renal transplant recipients, data are limited and…
2015 American Transplant Congress
Kidney Transplant Telehealh Clinic Improves Access to Long-Term Follow-Up and Decreases Costs: The Experience of the Iowa City VA Transplant Program
R. Kalil,^1,2 C. Thomas,^1,2 D. Katz.^1,2
¹Univesity of Iowa, Iowa City; ²Iowa City VAMC, Iowa City.
Kidney transplant (KT) recipients living in areas distant from transplant centers face more challenges in maintaining adequate follow-up due to long travel distances, greater costs,…
2015 American Transplant Congress
Gene Expression Profiles Indicate That Many Discarded Kidneys Are Potentially Transplantable
K. Famulski,¹ S. Niederhaus,² J. Reeve,¹ J. Bromberg,² P. Halloran.
¹University of Alberta, Edmonton, Canada; ²University of Marlyland, Baltimore.
We previously showed that the molecular kidney injury-repair response (AKI score) in implantation core biopsies (Bx) predict future graft function better than histology. This could…
2015 American Transplant Congress
Activation of FXR Protects Against Liver Ischemia and Reperfusion Injury (IRI) in Mice Via the PI 3-Kinase/Akt (PI3K/Akt) Pathway
J. Zhang,¹ X. Liu,² D. Li,¹ H. Dai,¹ J. Zhang,¹ T. Lu,¹ Q. Xia.¹
¹Liver Transplantation Center, Renji Hospital, Shanghai, China; ²Cardiovascular, Shanghai First People/s Hospital, Shanghai, China.
Background: FXR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily, which plays important roles in lipid metabolism, glucose homeostasis, inflammatory responses…
2015 American Transplant Congress
CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment
R. Hotta,¹ M. Ohira,² T. Matsuura,¹ I. Muraoka,¹ P. Tryphonopoulos,¹ J. Fan,¹ A. Tekin,¹ H. Ohdan,² A. Tzakis,³ R. Vianna,¹ S. Nishida.¹
¹University of Miami, Miami, FL; ²Hiroshima University, Hiroshima, Japan; ³Cleveland Clinic Florida, Weston, FL.
Background: T-cell depleting strategies have become an integral part of immunosuppressive regimens in organ transplantation. Alemtuzumab is a humanized monoclonal antibody against CD52, a cell-surface…