Am J Transplant, Volume 5, Suppl 3 Archives - Page 126 of 170 - ATC Abstracts

2015 American Transplant Congress
The Impact of Preoperative Antimicrobial Prophylaxis on Device-Related Infections in Recipients of Long-Term Mechanical Circulatory Support (MCS)
I. El Lakkis,¹ K. Lietz,² C. Derber,¹ U. Kelly,¹ C. Wilson,¹ A. Hoedt,² P. Bourasssa,² B. Smith,² M. McGrath,² J. Herre,² M. Mooney.¹
¹Eastern Virginia Medical School, Norfolk, VA; ²Sentara Norfolk General Hospital, Norfolk, VA.
Purpose: Although preoperative antimicrobial prophylaxis is recommended for patients undergoing long-term MCS device implantation, there is a lack of consensus as to the optimal preoperative…
2015 American Transplant Congress
Inadequate Overall Immunosuppression Is a Risk for Late Acute Rejection Despite Alemtuzumab Induction in Simultaneous Pancreas Kidney Transplant Recipients
J. Bank,¹ M. Mallat,¹ P. van der Boog,¹ D. Braat,² J. Ringers,² M. Vergunst,³ S. Heidt,³ F. Claas,³ M. Reinders,¹ J. de Fijter.¹
¹Nephrology, LUMC, Leiden, Netherlands; ²Surgery, LUMC, Leiden, Netherlands; ³IHB, LUMC, Leiden, Netherlands.
Introduction: Simultaneous pancreas-kidney transplantation (SPK) has become the treatment of choice for patients with end-stage renal disease due to Type 1 Diabetes Mellitus. SPK is…
2015 American Transplant Congress
Dual Induction Therapy With Anti-Thymocyte Globulin and Basiliximab in Simultaneous Pancreas-Kidney Transplantation Reduced Incidence of Acute Rejection
K. Miki, K. Iwadoh, I. Nakajima, S. Fuchinoue.
Tokyo Women Medical University, Kidney Center, Tokyo, Kawadacho, Japan.
【Background】Induction therapy in simultaneous pancreas-kidney transplant (SPK) recipients has been a common practice because a consequence of acute rejection (AR) in SPK could result in…
2015 American Transplant Congress
Kidney Retransplantation in the Ipsilateral Iliac Fossa; a Surgical Challenge
L. Ooms,¹ J. Roodnat,² F. Dor,¹ K. Tran,¹ D. Kimenai,¹ J. IJzermans,¹ T. Terkivatan.¹
¹Transplant Surgery, Erasmus Medical Center, Rotterdam, Netherlands; ²Nephrology, Erasmus Medical Center, Rotterdam, Netherlands.
Introduction: The aim of this study is to review the surgical outcome of kidney retransplantation in the ipsilateral iliac fossa in comparison to first kidney…
2015 American Transplant Congress
Distinct Clinical Relevance of BAFF Expression Within the Kidney Graft and Soluble BAFF Serum Levels Indicate Confined Alloimmune Responses Disconnected from the Periphery
E. Campos,^1,2 K. Mine,¹ A. Goncalves-Primo,^1,2 M. Soares,⁴ M. Franco,² J. Medina-Pestana,^2,3 H. Tedesco-Silva,³ M. Gerbase-DeLima.^1,2
¹Instituto de Imunogenética, AFIP, São Paulo, SP, Brazil; ²Universidade Federal de São Paulo, São Paulo, SP, Brazil; ³Hospital do Rim e Hipertensão- FOR, São Paulo, SP, Brazil; ⁴Universidade Federal do Parana, Curitiba, PR, Brazil.
As soluble B-cell activating factor (BAFF) serum levels (sBAFF) may not reflect BAFF concentrations within the graft, what could be related to the inconsistencies in…
2015 American Transplant Congress
Differentially Expressed IL-6Rα and GP130 Genes in Kidney Biopsies (Bxs) Suggests Different Roles of IL-6 Signaling in Antibody (ABMR)- and Cell (CMR)-Mediated Rejection
H. Zhang,¹ D. Thomas,¹ J. Kowalewska,² E. Suviolahti,¹ H. Shafi,² C. Nast,² A. Gertych,² A. Vo,¹ M. Haas,² S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: IL-6 exerts immunoregulatory properties through IL-6 receptors, IL-6Rα and gp130. Our previous studies suggested the involvement of antibody-dependent cellular cytotoxicity (ADCC) and its related…
2015 American Transplant Congress
Biopsychronology: Live Confocal Imaging of Biopsies to Assess Organ Function
M. Ashraf,¹ D. Fries,² W. Streif,³ F. Aigner,¹ P. Hengster,¹ J. Troppmair,¹ M. Hermann.²
¹VTT, DSL, Innsbruck Medical University, Innsbbruck, Austria; ²Anestesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria; ³Pediatrics I, Innsbruck Medical University, Innsbruck, Austria.
Methods to monitor the status of a graft prior to transplantation are highly desirable to avoid unnecessary clinical interventions and to optimize the clinical outcome…
2015 American Transplant Congress
Endosome-Based Activation of Non-Canonical NF-kB Signaling By Membrane Attack Complexes
D. Jane-wit,¹ Y. Surovtseva,² L. Qin,³ P. Clark,⁴ T. Manes,⁴ M. Kashgarian,⁵ N. Kirkiles-Smith,⁴ R. Liu,⁴ C. Wang,⁴ G. Tellides,³ J. Pober.⁴
¹Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT; ²Yale Center for Molecular Discovery, Yale University School of Medicine, New Haven, CT; ³Department of Surgery, Yale University School of Medicine, New Haven, CT; ⁴Department of Immunobiology, Yale University School of Medicine, New Haven, CT; ⁵Department of Pathology, Yale University School of Medicine, New Haven, CT.
Using sera from transplant patients with high-titer panel reactive antibody (PRA), we previously described a model for studying the effects of alloantibody binding and complement…
2015 American Transplant Congress
Myeloid Cell-Specific Heme Oxygenase-1 Is Crucial for Hepatoprotection in Liver Ischemia-Reperfusion Injury
K. Nakamura,¹ M. Zhang,² B. Ke,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California, Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA.
Background and Aim: Heme oxygenase-1 (HO-1), an anti-oxidant enzyme, is essential in tissue resistance against innate immunity driven ischemia-reperfusion injury (IRI). Our group was the…
2015 American Transplant Congress
The Onset of Post-Transplant Malignancies Is Related to a Change in Gene Expression Profiles in Peripheral Blood Mononuclear Cells
G. Stallone,¹ R. Federica,¹ P. Pontrelli,² M. Accetturo,² A. Oranger,² M. Gigante,² G. Castellano,² A. Schena,² M. Fiorentino,² B. Infante,¹ L. Gesualdo,² G. Grandaliano.¹
¹Dept.of Surgical and Medical Sciences, Nephrology Unit, University of Foggia, Foggia, Italy; ²Dept. of Emergency and Organ Transplantation, Nephrology Unit, University of Bari, Bari, Italy.
Malignancies are the third leading cause of death in renal transplant recipients and their incidence is increasing. Although the role of the immune system in…