2015 American Transplant Congress
CN Inhibition (But Not mTOR Inhibition) of a Novel CD8+ T Cell Regulatory Mechanism Results in Higher Alloantibody Posttransplant
Department of Surgery, CTC, The Ohio State University Wexner Medical Center, Columbus, OH.
MTOR inhibitors [mTORi; Rapamycin, (Rapa)] and calcineurin inhibitors [CNi; Tacrolimus (Tac)] are immunosuppressive drugs commonly used to suppress the rejection of transplanted organs and tissues.…2015 American Transplant Congress
Impact of Donor Specific Antibodies in the Older Kidney Transplant Recipient
Houston Methodist Hospital, Houston.
Recent evidence suggests that renal transplant recipients (RTR) with both rejection and donor specific antibodies (DSA) are at high risk of graft loss. Concurrently, the…2015 American Transplant Congress
National Transplantation Pregnancy Registry: Cholestasis of Pregnancy in Liver Transplant Recipients
Cholestasis of pregnancy (COP) occurs in approximately 1% of pregnancies and is associated with increased risk of premature delivery. The purpose of this study was…2015 American Transplant Congress
Outcomes of ABO Incompatible Kidney Transplantation in Children
Purpose: ABO blood group incompatible transplantation (ABOi) has become increasingly common over the last decade, in part due to a shortage of suitable deceased donor…2015 American Transplant Congress
The Gut Microbiota Regulates Murine Cardiac Transplant Outcome
1University of Maryland, Baltimore, MD; 2University of Hohenheim, Stuttgart, Germany.
Hypothesis: The gut microbiota regulates systemic immunity. Different characteristics of the microbiota can be defined that have pro- or anti-inflammatory effects. We tested the hypothesis…2015 American Transplant Congress
Assessment of IgG Subclass Significance for Early Graft Rejection and Long-Term Survival in HLA-Antibody Incompatible Renal Transplantation: Multivariate Approach
Donor HLA specific antibodies (DSA) can cause acute rejection and graft lost after renal transplantation. However neither the damaging antibody types, nor their acceptable levels…2015 American Transplant Congress
Epidemiology of Pneumonia in a Cohort of 5,000+ Abdominal Solid Organ Transplant Recipients
Baylor Scott & White Health, Dallas, TX.
Study purposeWe evaluated the epidemiology of pneumonia (PNE) in a longitudinal cohort of patients with abdominal (kidney, liver, and/or pancreas) solid organ transplants (SOT).MethodsRetrospective study…2015 American Transplant Congress
Impaired Autophagy: A Mechanism of Fatty Liver Increases Susceptibility to Ischemia Reperfusion Injury
BACKGROUND: Hepatic steatosis is associated with significant morbidity and mortality after transplantation. Autophagy was known as a protective response to ischemia and reperfusion (I/R) injury.…2015 American Transplant Congress
Human Leukocyte Antigen Mismatch and Steroid Maintenace in Kidney Transplantation
Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA.
Kidney transplant recipients (KTRs) with zero/minimal HLA mismatches against their donors enjoy superior long term outcomes related to diminished immune response of the recipient against…2015 American Transplant Congress
Changes in Utilization, Discard, and Outcomes Associated With Hepatitis C (+) Donor Livers in the Era of Direct Acting Anti-Retroviral Therapy
Johns Hopkins University, Baltimore, MD.
While 45% of liver candidates are hepatitis C (HCV) (+) and might benefit from an HCV (+) donor liver, only 7.1% receive one, and HCV…
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