Am J Transplant, Volume 5, Suppl 3 Archives - Page 119 of 170 - ATC Abstracts

2015 American Transplant Congress
Noncanonical Anergic Alloreactive B Cells in Transplantation Tolerance
J. Chen, M. Daniels, D. Yin, R. Sciammas, A. Chong.
Depart of Surgery, University of Chicago, Chicago.
The observation that operationally tolerant patients (TOL) display higher numbers of blood B cells and a B cell gene signature compared to stable kidney allograft…
2015 American Transplant Congress
Socioeconomic Determinants of Racial Disparities in Access to Preemptive Live Donor Kidney Transplantation
T. Purnell, X. Luo, A. Massie, D. Crews, L. Cooper, D. Segev.
Johns Hopkins, Baltimore.
Racial/ethnic minorities have less access to preemptive live donor kidney transplantation (PLDKT) than whites. Our objective was to examine determinants of racial/ethnic disparities in PLDKTs…
2015 American Transplant Congress
Inhibition of Endogenous Memory CD8 T Cell Infiltration Into Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage Is Required to Promote Long-Term Graft Survival
N. Kohei,¹ H. Tsuda,^1,3 T. Tanaka,^1,4 S. Iida,² T. Abe,³ C. Su,¹ D. Kish,¹ K. Tanabe,² A. Valujskikh,¹ R. Fairchild.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Urology Kidney Center, Tokyo Women's Medical University, Tokyo, Japan; ³Urology, Osaka University, Osaka, Japan; ⁴Urology, Sapporo Medical University, Sapporo, Japan.
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…
2015 American Transplant Congress
Risk Associated With DCD Kidney Transplantation Varies by Donor Characteristics
X. Luo, A. Massie, E. Chow, D. Segev.
Johns Hopkins, Baltimore.
Studies have shown that comparable kidney graft survival between donors after brain death (DBD) and donors after circulatory death (DCD) overall. However, the differential risk…
2015 American Transplant Congress
Refinement of Non-Invasive Diagnostic Criteria to Differentiate Tumor from Bland Portal Vein Thrombosis Before Liver Transplant in Patients With Hepatocellular Carcinoma
C. Sherman, S. Behr, J. Dodge, J. Roberts, F. Yao, N. Mehta.
University of California San Francisco, San Francisco, CA.
Differentiating tumor vs bland portal vein thrombosis (PVT) is essential in determining liver transplant (LT) candidacy for patients with hepatocellular carcinoma (HCC). The primary aim…
2015 American Transplant Congress
Germinal Centre Autoimmunity Mediates Progression of Allograft Vasculopathy, With Essential Help Provided By T Follicular Cells
M. Qureshi, R. Motallebzadeh, M. Chhabra, M. Negus, S. Rehakova, E. Bolton, J. Bradley, G. Pettigrew.
Dept of Surgery, University of Cambridge, Cambridge, United Kingdom.
Introduction: : In our previous work we have shown that donor CD4 T cells within heart grafts initiate anti-nuclear autoantibody responses. Here we clarify the…
2015 American Transplant Congress
Vascularized Bone Marrow Plays a Critical Role in Inducing Tolerance of Osteomyocutaneous Allografts
C.-H. Lin,¹ M. Anggelia,¹ Y.-L. Wang,¹ H.-Y. Cheng,¹ W. Lee,² G. Brandacher.²
¹Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taipei, Taiwan; ²Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: Vascularized composite allograft (VCA) that includes medullary bone may provide proposed benefits ofvascularized bone marrow transplantation (VBMT), such as a continuous supply of donor…
2015 American Transplant Congress
1-Year Safety and Efficacy of Eculizumab in Adult aHUS Patients, With or Without a History of Renal Transplant
C. Legendre,¹ J. Kincaid,² C. Bedrosian,² C. Loirat.³
¹University Paris Descartes & Hôpital Necker, Paris, France; ²Alexion, Cheshire, CT; ³Assistance Publique–Hôpitaux Paris, Hôpital Robert-Debré, Paris, France.
Background: Atypical hemolytic-uremic syndrome (aHUS) is a life-threatening, chronic disease of complement-mediated TMA. In aHUS, renal transplantation is associated with post-transplant (TP) TMA and ∼50–70%…
2015 American Transplant Congress
Impact of Elevated BMI on Allograft Outcomes: A Competing Risks Regression Analysis
A. Naik, A. Sakhuja, M. Samaniego, P. Shrivastava, D. Cibrik.
Section of Nephrology, University of Michigan, Ann Arbor, MI.
INTRODUCTION: Extremes of BMI has been associated with an increased risk of death censored allograft failure. Traditionally the KM product limit estimate has been used…
2015 American Transplant Congress
The Impact of Acute Rejection on Liver Transplant Survival in the New Millennium
J. Levitsky,¹ S. Forney,² B. Gillespie,³ R. Merion,^2,3 A. Lok,³ G. Levy,⁴ L. Kulik,¹ M. Abecassis,¹ A. Shaked.⁵
¹Northwestern U, Chicago, IL; ²Arbor Research Collaborative for Health, Ann Arbor, MI; ³U Michigan, Ann Arbor, MI; ⁴U Toronto, Toronto, ON, Canada; ⁵U Pennsylvania, Philadelphia, PA.
Background: Based on pre-2000 data, acute rejection (AR) has long been considered clinically less significant in liver transplant (LT) vs. other organ recipients (Charlton et…