Am J Transplant, Volume 5, Suppl 3 Archives - Page 116 of 170 - ATC Abstracts

2015 American Transplant Congress
Rapid Effector Function of TEMRA CD8 T Cells in Healthy Volunteers and in Immune-Stimulated Patients Requires Sustained Glycolytic Switch
M. Yap,^1,3 G. Tilly,^1,3 M. Giral,^1,2 D.-A. Laplaud,^1,2 S. Brouard,^1,2 C. Pecqueur,⁴ N. Degauque.^1,2
¹INSERM UMR1064, Nantes, France; ²CHU de Nantes, Nantes, France; ³University of Nantes, Nantes, France; ⁴INSERM UMR892, Nantes, France.
Background. Contradictory observations have been published regarding the functionality of TEMRA CD8 T cells. TEMRA CD8 have been shown to accumulate with age or chronic…
2015 American Transplant Congress
Liver-Specific Transcription Factor ATF5 Participates in Regulation of IFN-γ/B7-H1 Signaling Pathway in Liver Mesenchymal Cells
G.-Q. Shen, L. Wang, J. Fung, L. Lu, S. Qian.
Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Insttute, Cleveland Clinic, Cleveland, OH.
Liver transplant tolerance was initially discovered in pigs, rats and mice. A recent paper reviewed ∼400 liver transplant patients worldwide who had undergone weaning of…
2015 American Transplant Congress
Serum Phosphorus Level Has Bidirectional Association With Graft Failure and Mortality in Kidney Transplant Recipients
H. Jeon,¹ J. An,² K. Joo,¹ C. Lim,² Y. Oh,² C. Ahn,¹ S.-K. Park,³ Y. Kim,¹ Y. Kim,⁴ J. Lee.²
¹Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; ²Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea; ³Department of Internal Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Republic of Korea; ⁴Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Republic of Korea.
Hyperphosphatemia in kidney transplant recipients (KTRs) is known to predict a graft and patient survival in several studies. However, studies concerned with hypophosphatemia are scarce.…
2015 American Transplant Congress
Does HLA-Incompatible Transplantation Confer a Survival Advantage in the UK?
M. Manook,¹ Z. Ahmed,¹ R. Johnson,² O. Shaw,¹ N. Kessaris,¹ A. Dorling,¹ N. Mamode.¹
¹Renal, Guy's & St Thomas' Hospital, London, United Kingdom; ²NHS Blood & Transplant, Bristol, United Kingdom.
Introduction: HLA-incompatible transplantation is perceived as being a 'high-risk' option with increased mortality and morbidity for transplantation of sensitized recipients of renal transplants. Data from…
2015 American Transplant Congress
Angiopoietin-2 Associates With Graft Failure and Mortality in Renal Transplant Recipients
W. Westendorp,¹ C. Keyser,² E. van den Berg,² C. Krikke,¹ H. van Goor,³ S. Bakker,² H. Leuvenink.¹
¹Surgery, Groningen Transplant Center, University Medical Center Groningen, Groningen, Netherlands; ²Nephrology, Groningen Transplant Center, University Medical Center Groningen, Groningen, Netherlands; ³Pathology, University Medical Center Groningen, Groningen, Netherlands.
Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) are involved in stabilizing the vascular endothelium and may play a role in premature mortality and graft failure in renal…
2015 American Transplant Congress
An Orchestrated Sequence of Innate and Adaptive Immune Responses Is Associated With Rejection After Pediatric Liver Transplantation
C. Falk,¹ I. Goldschmidt,² F. Mutschler,² C. Neudörfl,¹ J. Keil,¹ K. Daemen,¹ F. Lehner,³ R. Mikolajzcyk,⁴ A. Karch,⁴ U. Baumann.²
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Division of Pediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany; ³Department of Visceral General and Transplant Surgery, Hannover Medical School, Hannover, Germany; ⁴Department of Epidemiology, Helmholtz Center for Infection Research, HZI, Braunschweig, Braunschweig, Germany.
The concept of a coordinated immune response initiated by innate and sustained by adaptive immune cells and their soluble mediators is well established for infection…
2015 American Transplant Congress
Distinct Roles of CD137 and CD137L Bi-Directional Signaling in Candida albicans Infection
H. Cho,^1,2 J. Lee,^2,3 V. Tran,⁴ B. Kwon.^2,4
¹Department of Surgery, Ulsan University Hospital, Ulsan, Korea; ²Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea; ³Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea; ⁴School of Biological Sciences, University of Ulsan, Ulsan, Korea.
Invasive fungal infections by Candida albicans frequently cause mortality in immunocompromised patients, yet the cellular processes leading to this mortality remain ill-defined. Here, using genetic…
2015 American Transplant Congress
Early Steroid Withdrawal and Infection Risk in Kidney Transplant Recipients
S. Bae, L. Kucirka, C. Durand, B. Orandi, R. Avery, D. Segev.
Johns Hopkins, Baltimore, MD.
BACKGROUND: While early steroid withdrawal (ESW) is hypothesized to lower the risk of infection, previous studies failed to demonstrate this benefit. These were limited by…
2015 American Transplant Congress
Conversion from Immediate to Prolonged Release Tacrolimus Did Not Change Intra-Patient Variability in Renal Transplant Patients
T. El-Nahhas,^1,2 M. Moreton,² J. Popoola,³ S. Abat,³ A. Johnston,^1,2 I. MacPhee.³
¹Clinical Pharmacology Department, William Harvey Research Institute, Barts and The London, Queen Mary University of London, London, United Kingdom; ²Analytical Services International, St. George's University of London, London, United Kingdom; ³Institute of Medical and Biomedical Education-Renal Medicine, St. George's University of London, London, United Kingdom.
Background. Tacrolimus has a narrow therapeutic index and is characterized by a large inter- and intra-patient variability (IPV). Variable blood tacrolimus concentrations have been shown…
2015 American Transplant Congress
Pharmacokinetics of Mycophenolic Acid (MPA) in Elderly Compared to Young Recipients in the First Year After Renal Transplantation. Data from the NEverOLd Trial
P. Romano,¹ F. Agena,² P. Ebner,¹ A. Triboni,² F. Ramos,² N. Galante,² F. Lemos,² N. Sumita,¹ E. David-Neto.²
¹Division of Central Laboratory, – Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil; ²Renal Transplantation Service, – Hospital das Clinicas – University of São Paulo School of Medicine, Sao Paulo, Brazil.
Elderly (≥60years) recipients are nowadays receiving renal transplants more frequently. The pharmacokinetics studies (PK) of immunosuppressive drugs in healthy volunteers, rarely, if ever, include old…