Am J Transplant, Volume 5, Suppl 3 Archives - Page 116 of 170 - ATC Abstracts

2015 American Transplant Congress
Patient Self-Reported Adherence to and Perceptions Towards Immunosuppressive Medications at the Outpatient Renal Transplant Clinic at St. Joseph's Healthcare Hamilton (SJHH)
K. Kak,¹ C. Burger,¹ D. Treleaven,² C. Wallace.¹
¹Pharmacy, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada; ²Medicine, McMaster University, Hamilton, ON, Canada.
Objectives To gain insight into the immunosuppressant adherence of patients followed by the Outpatient Renal Transplant Clinic at St. Joseph's Healthcare Hamilton (SJHH) and to…
2015 American Transplant Congress
Dietary-Associated Trimethylamine N-Oxide (TMAO) Levels Is associated With Coronary Allograft Vasculopathy Following Heart Transplantation
S. Zeltzer,¹ Z. Wang,¹ M. Askar,² J. Coughlin,¹ T. Hudec,¹ D. Taylor,³ L. Li,¹ R. Starling,³ S. Hazen,¹ W. Tang.¹
¹Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH; ²Transplant Center, Cleveland Clinic, Cleveland, OH; ³Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH.
Background: Coronary allograft vasculopathy (CAV) is a leading cause of cardiac graft failure after 1 year post transplant. It is characterized by an inflammatory vascular…
2015 American Transplant Congress
Chimeric Patients Who Undergo Combined Facilitating Cell-Enriched/HSC/Renal Transplant Exhibit Robust TCR Repertoire
I. Konieczna,¹ J. Mathew,¹ J. Miller,¹ S. Ildstad,^2,3 J. Leventhal.¹
¹Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, IL; ²Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; ³Regenerex, LLC, Louisville, KY.
Combined donor kidney plus facilitating cell enriched hematopoietic stem cell (FCRx) transplants (Tx), after low intensity conditioning with fludarabine, 200-cGy total body irradiation and cyclophosphamide…
2015 American Transplant Congress
Molecular and Functional Immune Assays as Non-Invasive Diagnostic Tools to Assess the Risk of Acute Subclinical Rejection After Kidney Transplantation
O. Bestard,^1,2 E. Crespo,¹ T. Sigdel,² S. Roedder,² Y. Ng,² J. Cruzado,¹ M. Lúcia,¹ S.-C. Hsieh,¹ T. Tran,¹ J. Grinyó,¹ M. Sarwal.¹
¹Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, CAT, Spain; ²Department of Transplant Surgery, UCSF, San Francisco, CA.
Subclinical allograft rejection (sc-AR) is still a main cause of allograft loss that can only be assessed through invasive surveillance biopsies. We sought to investigate…
2015 American Transplant Congress
Ischemia Reperfusion Injury in Orthotopic Liver Transplantation Primes the Adaptive Immune Response and Generation of Proinflammatory Cytokines
A. Zarrinpar,¹ P. Rao,² C. Lassman,² V. Agopian,¹ F. Kaldas,¹ D. Farmer,¹ R. Busuttil,¹ Y. Zhai,¹ J. Kupiec-Weglinski,¹ E. Reed.²
¹Surgery, University of California, Los Angeles, Los Angeles, CA; ²Pathology and Lab Medicine, University of California, Los Angeles, Los Angeles, CA.
Background: Transplanted organs are exquisitely susceptible to effects of ischemia/reperfusion injury (IRI), an immune-mediated process that occurs during transplantation and beyond. Recipient and graft outcomes,…
2015 American Transplant Congress
Rapid Effector Function of TEMRA CD8 T Cells in Healthy Volunteers and in Immune-Stimulated Patients Requires Sustained Glycolytic Switch
M. Yap,^1,3 G. Tilly,^1,3 M. Giral,^1,2 D.-A. Laplaud,^1,2 S. Brouard,^1,2 C. Pecqueur,⁴ N. Degauque.^1,2
¹INSERM UMR1064, Nantes, France; ²CHU de Nantes, Nantes, France; ³University of Nantes, Nantes, France; ⁴INSERM UMR892, Nantes, France.
Background. Contradictory observations have been published regarding the functionality of TEMRA CD8 T cells. TEMRA CD8 have been shown to accumulate with age or chronic…
2015 American Transplant Congress
Liver-Specific Transcription Factor ATF5 Participates in Regulation of IFN-γ/B7-H1 Signaling Pathway in Liver Mesenchymal Cells
G.-Q. Shen, L. Wang, J. Fung, L. Lu, S. Qian.
Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Insttute, Cleveland Clinic, Cleveland, OH.
Liver transplant tolerance was initially discovered in pigs, rats and mice. A recent paper reviewed ∼400 liver transplant patients worldwide who had undergone weaning of…
2015 American Transplant Congress
Serum Phosphorus Level Has Bidirectional Association With Graft Failure and Mortality in Kidney Transplant Recipients
H. Jeon,¹ J. An,² K. Joo,¹ C. Lim,² Y. Oh,² C. Ahn,¹ S.-K. Park,³ Y. Kim,¹ Y. Kim,⁴ J. Lee.²
¹Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; ²Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea; ³Department of Internal Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Republic of Korea; ⁴Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Republic of Korea.
Hyperphosphatemia in kidney transplant recipients (KTRs) is known to predict a graft and patient survival in several studies. However, studies concerned with hypophosphatemia are scarce.…
2015 American Transplant Congress
Does HLA-Incompatible Transplantation Confer a Survival Advantage in the UK?
M. Manook,¹ Z. Ahmed,¹ R. Johnson,² O. Shaw,¹ N. Kessaris,¹ A. Dorling,¹ N. Mamode.¹
¹Renal, Guy's & St Thomas' Hospital, London, United Kingdom; ²NHS Blood & Transplant, Bristol, United Kingdom.
Introduction: HLA-incompatible transplantation is perceived as being a 'high-risk' option with increased mortality and morbidity for transplantation of sensitized recipients of renal transplants. Data from…
2015 American Transplant Congress
Angiopoietin-2 Associates With Graft Failure and Mortality in Renal Transplant Recipients
W. Westendorp,¹ C. Keyser,² E. van den Berg,² C. Krikke,¹ H. van Goor,³ S. Bakker,² H. Leuvenink.¹
¹Surgery, Groningen Transplant Center, University Medical Center Groningen, Groningen, Netherlands; ²Nephrology, Groningen Transplant Center, University Medical Center Groningen, Groningen, Netherlands; ³Pathology, University Medical Center Groningen, Groningen, Netherlands.
Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) are involved in stabilizing the vascular endothelium and may play a role in premature mortality and graft failure in renal…