Am J Transplant, Volume 5, Suppl 3 Archives - Page 11 of 170 - ATC Abstracts

2015 American Transplant Congress
Outcome of Kidney Transplantation from Obese Living Donors: Histological Evaluation Using Zero-Time Biopsy Specimens
K. Omoto,¹ D. Toki,¹ M. Okumi,¹ T. Shimizu,¹ H. Ishida,¹ K. Honda,² J. Koike,³ K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan; ³Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan.
BACKGROUND AND OBJECTIVE: The relationship between preimplantation biopsy and graft outcome in kidney transplantation from obese living donors has not been studied. We reviewed graft…
2015 American Transplant Congress
Lung Transplantation (LTx) in Patients on Extracorporeal Support – Is It a Bridge Too Far? A Single Centre Cohort Analysis
B. Zych, D. Garcia-Saez, P. Mohite, A. Reed, F. De Robertis, A. Popov, M. Amrani, T. Bahrami, N. Patil, M. Carby, A. Simon.
Department of Cardio-Thoracic Transplantation & Mechanical Circulatory Support, Harefield Hospital. Royal Brompton & Harefield NHS Foundation Trust, Harefield, Middlesex, United Kingdom.
Objective: LTx in patients remaining on extracorporeal support is still controversial approach despite good results published by leading transplant centres. In this study we evaluate…
2015 American Transplant Congress
Change in Frailty Between Evaluation for Kidney Transplantation and Transplantation
M. McAdams DeMarco, E. King, N. Desai, N. Dagher, B. Lonze, R. Montgomery, D. Segev.
Johns Hopkins, Baltimore, MD.
BACKGROUND: Frailty prevalence is high and predicts early hospital readmission, length of stay and mortality in adults of all ages undergoing kidney transplantation (KT). The…
2015 American Transplant Congress
Are DQA Antibodies Real?
J. Jones, D. Lucas, M. Leffell, A. Zachary.
Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Antibodies specific for HLA-DQ antigens appear to be increasing in frequency in the post-transplant period and are difficult to reduce effectively with desensitization protocols using…
2015 American Transplant Congress
Influence of POR*28 Genotype on Tacrolimus Disposition in Heart Transplant Recipients
T. Alford,¹ R. Page,¹ J. Lindenfeld,² C. Aquilante.¹
¹University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO; ²University of Colorado School of Medicine, Aurora, CO.
Polymorphisms in P450 oxidoreductase (POR) have been shown to modulate CYP3A activity and alter the pharmacokinetics of CYP3A substrates, such as tacrolimus (TAC). The objective…
2015 American Transplant Congress
Identification of Genetic Variants Associated With Variation of Tacrolimus Levels in African Americans Using GWAS
W. Oetting,¹ D. Schladt,² W. Guan,¹ A. Israni,² R. Remmel,¹ C. Dorr,² K. Sanghavi,¹ R. Mannon,³ B. Herrera,⁴ A. Matas,¹ D. Salomon,⁵ P. Kwok,⁴ P. Jacobson,¹ for DeKAF Genomics.¹
¹Univ. of Minnesota, Minneapolis; ²Minneapolis Medical Research Foundation, Minneapolis; ³Univ. of Alabama, Birmingham; ⁴Univ. of California, San Francisco; ⁵Scripps Research Center, La Jolla.
African American kidney transplant recipients (AA) have a higher incidence of allograft failure when compared to Caucasians. We have previously reported that tacrolimus troughs (TT)…
2015 American Transplant Congress
Immunomodulatory Strategies Directed Towards Tolerance of Vascularized Composite Allografts
M. Madariaga, K. Shanmugarajah, S. Michel, V. Villani, G. La Muraglia II, R. Torabi, D. Leonard, M. Randolph, R. Colvin, K. Yamada, J. Madsen, C. Cetrulo, Jr., D. Sachs.
Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Background: Achieving tolerance of vascularized composite allografts (VCAs) would improve the risk-to-benefit ratio in patients who undergo this life-enhancing transplant. Kidney co-transplantation along with a…
2015 American Transplant Congress
Tissue Engineering Human Kidneys for Costimulation Blockade
L. Brasile,¹ N. Henry,¹ A. Meyer,¹ B. Stubenitsky.²
¹BREONICS, Inc., Watervliet, NY; ²Surgery, University of Utrecht, Utrecht, Netherlands.
Methods for preserving organs have employed hypothermic conditions. At these temperatures metabolism is 4% of normal. Tissue engineering of organs cannot be done without significant…
2015 American Transplant Congress
B-Cell Activation in Acute Kidney Injury and Delayed Graft Function
M. Schiffer,¹ F. Wiehler,¹ R. Song,¹ R. Chen,¹ L. Schiffer,¹ M. Mengel,² H. Haller,¹ F. Gueler.¹
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Pathology, University of Alberta, Edmonton, Canada.
Background:Acute kidney injury (AKI) is a relevant complication after kidney transplantation and also after non-renal solid organ transplantation. Growing evidence points towards an important role…
2015 American Transplant Congress
Lessons Learned from the Clinical Use of Normothermic Regional Perfusion (nRP) in Uncontrolled Donation After Circulatory Death (DCD)
C. Antoine,¹ E. Savoye,¹ F. Gaudez,² G. Cheisson,³ M. Videcoq,⁴ B. Barrou,⁵ National Steering Committee of Donation After Circulatory Death.¹
¹Medical and Scientific Department, Agence de la Biomedecine, LA Plaine Saint Denis, Saint Denis, France; ²Department of Urology, Saint Louis Hospital, Paris, France; ³Department of Anesthesia and Critical Care, Bicetre Hospital, Kremlin Bicetre, Val de Marne, France; ⁴Department of Transplantation, Edouard Herriot Hospital Group, Lyon, Rhones Alpes, France; ⁵Department of Anesthesia and Critical Care, Hôtel-Dieu Hospital, Nantes, Pays de la Loire, France; ⁶Department of Urology, University Hospital La Pitie, Paris, France.
The national protocol for the uDCD program restricts donor age < 55 y, no flow period < 30 min and total warm ischemia time (WIT)…