2015 American Transplant Congress
Short- and Long-Term Outcomes of Mycophenolate Versus Azathioprine in a Large Cohort of Renal Transplant Recipients
1Barnes-Jewish Hospital, St. Louis; 2Washington University School of Medicine, St. Louis.
Purpose: Early studies comparing mycophenolate mofetil (MMF) to azathioprine (AZA) post-renal transplantation demonstrated superiority of MMF over AZA for the prevention of acute rejection (AR).…2015 American Transplant Congress
Post-Liver Transplant Metabolic Syndrome Increases the Risk of Recurrent Fibrosis in Patients With Hepatitis C
Department of Medicine, Columbia University, New York, NY.
Introduction: Post-liver transplant (LT) metabolic syndrome (MS) is common and may impact fibrosis progression in LT recipients with hepatitis C virus (HCV). Methods: All adults…2015 American Transplant Congress
Repurposing Jak/STAT Signaling Inhibition to Enhance Costimulation Blockade and Promote Transplant Acceptance
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore.
PURPOSE: Transplant tolerance induction through conventional costimulation blockade (CoB) remains an elusive goal. Recent evidence suggests that inflammatory cytokines contribute to the activation of alloreactive…2015 American Transplant Congress
Allogeneic Monocyte–Endothelial Cell Interaction Plays a Critical Role in Initiating Early Pro-Fibrosis Responses
Surgery, Duke University Medical Center, Durham, NC.
Chronic allograft nephropathy (CAN), characterized by interstitial fibrosis, vascular intimal thickening, and glomerulosclerosis, has remained as leading cause of allograft failure. The role of innate…2015 American Transplant Congress
Functional Decline in Liver Transplant Candidates: Results from the Functional Assessment in Liver Transplantation (FrAILT) Study
Background: Cirrhosis is characterized by sarcopenia and malnutrition, leading to progressive functional decline. No studies have objectively measured physical functional decline in cirrhotics awaiting liver…2015 American Transplant Congress
Effectiveness of Protocol-Driven Induction Therapy in Adult Kidney Transplant Recipients
Background: Induction therapy significantly improves graft outcomes in kidney transplantation, but the optimal agent based on patient characteristics and immunologic risk is unknown. While many…2015 American Transplant Congress
Final Results from the BENEFIT-EXT Trial: A 7 Year Follow-Up of Belatacept Treated Patients
Background: At 3 and 5yrs post-transplant, BENEFIT-EXT showed a renal function benefit and consistent safety in belatacept (bela) treated pts vs cyclosporine (CsA). Final 7…2015 American Transplant Congress
Eomes-Expressing CD8+ T Cells and Th17 Cells Mediate Costimulatory Blockade-Resistant Allograft Rejection in Mice
The etiology of costimulatory blockade-resistant allograft rejection remains unclear. Therefore, the purpose of this study was to evaluate the responsiveness of distinct CD4+ and CD8+…2015 American Transplant Congress
A Gene Expression Assessment for Improving Disease Activity and Stage in Heart ABMR
Paris Transplant Group & ATAGC, Paris - Edmonton, France.
BackgroundABMR is a major cause of heart transplant failure. The diagnosis of ABMR in heart transplantation is based on the 2013 ISHLT pAMR classification. We…2015 American Transplant Congress
Gender Disparity in Infections After Kidney Transplantation
BACKGROUND: Female gender has been suggested as a risk factor for infection after kidney transplant (KT). Preliminary studies have reported that sex hormones such as…
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