ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Preemptive Rituximab Therapy of Epstein-Barr Virus (EBV) Infection to Prevent Post-Transplant Lymphoproliferative Disease (PTLD) After Pediatric Solid Organ Transplantation (SOT)

    Y. Ahn,1 N.-J. Yi,2 S. Min,2 I.-S. Ha,1 H. Cheong,1 H. Kang.1

    1Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea; 2Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea.

    Purpose: More than 90% of pediatric PTLD after solid organ transplantation is associated with EBV infection. Reduction in immunosuppression is the first step to prevent…
  • 2015 American Transplant Congress

    IL-2-Dependent Natural Killer Cell Responses to Epstein-Barr Virus B Cell Lymphomas Involve the NKG2A/NKG2C Axis

    O. Hatton, D. Strauss-Albee, C. Blish, C. Esquivel, S. Krams, O. Martines.

    Stanford University School of Medicine, Stanford, CA.

    Epstein Barr virus (EBV) infection elicits a strong host immune response that is considered to be essential for control of the virus and for preventing…
  • 2015 American Transplant Congress

    T-Cell Immune Function Vs. Gene Expression Profiling for Heart Transplant Rejection

    M. Luu, M. Kittleson, J. Patel, F. Liou, S. Siddiqui, L. Piponniau, A. Hage, D. Chang, L. Czer, A. Trento, J. Kobashigawa.

    Cedars-Sinai Heart Institute, Los Angeles, CA.

    Purpose: Non-invasive immune monitoring of heart transplant (HTx) patients (pts) is increasing in use. The AlloMap® blood test has proven helpful in surveillance of cardiac…
  • 2015 American Transplant Congress

    Incidence and Characteristics of CMV Infection in High Risk (D+R-) Kidney Transplant Recipients and the Utility of Monthly Surveillance After Routine Prophylaxis

    M. Bhattarai, C. Puttarajappa, G. Mour, C. Wu, P. Sood, N. Shah, R. Mehta, A. Tevar, S. Hariharan.

    Internal Medicine, University of Pittsburgh, Pittsburgh, PA.

    Cytomegalovirus (CMV) infection is the most common opportunistic viral infection after renal transplantation. Optimal duration of antiviral prophylaxis and the role of post prophylaxis surveillance…
  • 2015 American Transplant Congress

    A Novel Humanized Mouse Model for the Study of Induced Pluripotent Stem Cell-Derived Tissue Transplantation Tolerance and Function

    M. Brown, I. Norman, Y. Zhou, J. Sullivan, W. Burlingham.

    Surgery/Transplant Division, University of Wisconsin-Madison, Madison, WI.

    Patient-specific induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine therapies, theoretically allowing for the creation of autologous replacement tissues devoid of many…
  • 2015 American Transplant Congress

    Invasive CMV-Infection of the Duodenal Cuff – An Underestimated Entity of CMV Infection and Its Potential Impact On Outcome After Pancreas Transplantation

    A. Biglarnia,1 B. von Zur-Mühlen,1 S. Yamamoto,1 D. Berglund,1 M. Wagner,2 A. Sedigh,1 G. Tufveson,1 E. Larsson,3 F. Sund.2

    1Transplantation, Surgical Sciences, Uppsala, Sweden; 2Medical Scinces, Upsala, Sweden; 3Genetics and Pathology, Uppsala, Sweden.

    IntroductionWe present data on the incidence of focal invasive CMV-infection of the duodenal cuff and its potential impact on clinical outcome after pancreas transplantation (PT).Material…
  • 2015 American Transplant Congress

    Furthering the Link Between Ischemia and Immunity: Development of New Antibody Following Prolonged Delayed Graft Function

    A. Gilbert,1 E. Hall,1 O. Timofeeva,2 M. Awwad,2 M. Grafals,1 P. Weems,1 D. Li,2 S. Rosen-Bronson,2 J. Moore,1 B. Javaid,1 M. Cooper.1

    1Department of Surgery, MedStar Georgetown Transplant Institute, Washington, DC; 2Department of Pathology, MedStar Georgetown Transplant Institute, Washington, DC.

    Introduction The purpose of this study is to examine the relationship between prolonged ischemia (delayed graft function - DGF) and the development of de novo…
  • 2015 American Transplant Congress

    Discard of Kidneys at the Margin: ECD Versus KDPI Era

    S. Bae, A. Massie, D. Segev.

    Johns Hopkins, Baltimore, MD.

    BACKGROUND: Since 3/26/2012, the Kidney Donor Profile Index (KDPI), a percentile score reflecting donor-associated risk, has been provided with all deceased-donor kidney offers. We investigated…
  • 2015 American Transplant Congress

    New SRTR Risk-Adjustment Models for Adult Kidney Transplant Outcomes

    J. Snyder,1 N. Salkowski,1 D. Zaun,1 H. Xiong,1 S. Leppke,1 B. Thompson,1 D. Segev,1,2 L. Hunsicker,1 A. Israni,1 B. Kasiske.1

    1Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN; 2Johns Hopkins University, Baltimore, MD.

    Following a recommendation of the Consensus Conference on Transplant Program Quality and Surveillance, SRTR implemented a 3-year rolling cycle to rebuild the statistical models used…
  • 2015 American Transplant Congress

    Toll-Like Receptor 4-Signaling Abrogates Inhibitory Effect of Calcineurin Inhibitor on B-Cells Responding to Blood Group A-Antigens

    H. Sakai, Y. Tanaka, H. Ohdan.

    Transplant Unit, Hiroshima University, Hiroshima, Japan.

    Aim: Bacterial infection following ABO-incompatible organ-transplantation is associated with refractory Ab-mediated rejection. Here, we investigated the influence of toll-like receptor (TLR)-signaling, via the binding of…
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