2015 American Transplant Congress
Donor Derived Transmission Events in 2014: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC)
Background: The OPTN DTAC, a multidisciplinary committee, evaluates potential donor derived transmission events (PDDTE), including infections (I) & malignancies (M), to assess for donor transmitted…2015 American Transplant Congress
Decline in Estimated Glomerular Filtration Rate and Subsequent Risk of Graft Failure and Mortality Among Kidney Transplant Recipients
Purpose: Graft loss and death are generally late events after kidney transplantation, and trials designed to assess the impact of interventions on these outcomes are…2015 American Transplant Congress
Effective Long-Term Prophylaxis against De Novo Hepatitis B With Hepatitis B Vaccination in Pediatric Recipients of HbcAb-Positive Liver Grafts
Department of Surgery, Samsung Medical Center, Seoul, Korea.
Background) Controversy still exists concerning the use of livers from hepatitis B surface antigen-negative (HBsAg-)/hepatitis B core antibody-positive (HBcAb+) donors for liver transplantation (LT). We…2015 American Transplant Congress
Left Ventricular Assist Device–Associated Allosensitization — Clinical Implications
U.T.A.H. Cardiac Transplant Program, Salt Lake City, UT.
Purpose: Allosensitization has been recognized as a prognostic marker of worse outcome after transplant. It is unclear, however, whether sensitization events that take place shortly…2015 American Transplant Congress
Survival Benefit of ECD Transplantation After Ultra-Long Dialysis Exposure: Implications for Acceptance in the New KAS
Division of Nephrology, University of British Columbia, Vancouver, BC, Canada.
The survival benefit of ECD transplantation varies with the duration of pre-transplant dialysis exposure.We analyzed the survival benefit of ECD transplantation (Kidney Donor Profile Index…2015 American Transplant Congress
Association Between Histological Abnormalities in Time-Zero Renal Biopsies and Post-Donation eGFR in Live Donors
Time-zero biopsies (T0-RBx) of live-donor kidneys may reveal histological abnormalities at the time of organ recovery. The association between T0-RBx and subsequent kidney function in…2015 American Transplant Congress
Comparison of T Regulatory (Treg) Cell Function Pre- and Post-Lung Transplantation Shows a Major Negative Impact of Immunosuppression on Treg Function
Aim: Clinical lung Tx recipients do not have sustained long-term survival outcomes comparable to that of other recipients of solid organ allografts, despite generally comparable…2015 American Transplant Congress
Generation, Cryopreservation, Function and In Vivo Fate of Ex-Vivo Expanded Cynomolgus
Background:Foxp3+ regulatory T cells (Treg) function to promote immune tolerance and prevent immunopathogenesis. Preclinical studies have demonstrated that adoptive transfer of Treg prevents rejection of…2015 American Transplant Congress
CD4 T Cell Mediated Help Is Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…2015 American Transplant Congress
Donor-Derived Cell-Free DNA Is Stable in Non-Rejecting Heart Transplant Recipients in the CARGO II Multicenter Trial
1CareDx, Inc, Brisbane, CA; 2Drexel University, University of Philadelphia, Philadelphia, PA.
Purpose: An elevated fraction of donor-derived cell-free DNA (dd-cfDNA) detected in the venous blood of recipients has been shown to be correlated to rejection of…
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