2015 American Transplant Congress
Inflammatory Profiling of Hypothermic Machine Pumped Kidney Allografts
Medicine, University of California, San Diego, La Jolla, CA.
Background:Pulsatile Hypothermic Machine Perfusion (MP) offers an opportunity to define inflammatory molecules generated during renal ischemia. This study reports on allografts pumped at our OPO,…2015 American Transplant Congress
The Utility of Non-Invasive Intra Abdominal Pressure Monitoring After Pediatric Abdominal Organ Transplantation
Intra abdominal pressure (IAP) is monitored in critically ill children because intra-abdominal hypertension (IAH) may be associated with renal dysfunction and adverse outcomes.We retrospectively examined…2015 American Transplant Congress
Lower Frequency of Regulatory T-Cells After Conversion from CNIs or mTORi to Belatacept in a Prospective Matched Controlled Study in Renal Allograft Recipients
Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Objective: Regulatory T-cells (Tregs) are considered to play a crucial role in maintaining control of immune response following renal transplantation (Tx). So far, only limited…2015 American Transplant Congress
CTLA4Ig Administered During T-Cell Priming Negates de novo Alloantibody Responses and Modulates Recall Antibody Production
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Arcadia, CA.
Background CTLA4Ig (Belatacept) is a novel anti-rejection therapy aimed at costimulatory blockade. Clinical data suggest that post-transplant alloantibody formation is also reduced in patients treated…2015 American Transplant Congress
Temporal Increase in the Incidence of Post-Transplantation Lymphoproliferative Disorder in Adult Renal Transplant Recipients: Analysis of 2 US Insurance Administrative Claims Databases
Bristol-Myers Squibb Company, Princeton, NJ.
Purpose: Post-transplant lymphoproliferative disorder (PTLD) is a serious complication after kidney transplant. In a prior analysis using Medicare claims database from 1995 to 2003, the…2015 American Transplant Congress
HLA-DR Matching Improves Immunologic Outcomes in Elderly Kidney Transplant Recipients
Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany.
BACKGROUND: The Eurotransplant senior program (ESP) neglects HLA matching for elderly (>65y) KTR. Only few data exist regarding the influence of HLA-DR-matching on immunologic outcomes.PATIENTS…2015 American Transplant Congress
The Role of Inflammasome Components in Renal Tubular Epithelial Cell Injury
Background:Inflammasomes are multiprotein complexes of pattern recognition receptors (PRRs) recognized as key triggers of cellular injury. TLRs provide the first signal for induction of the…2015 American Transplant Congress
Diabetes Exacerbates Liver Ischemia and Reperfusion Injury By Activating the AGE-RAGE Pathway in Kupffer Cells
Surgery, UCLA, Los Angeles, CA.
Although pre-transplant diabetes has been documented as a risk factor for mortality post-liver transplant, the underlying mechanism remains obscure. In a murine liver partial warm…2015 American Transplant Congress
NK Cells of Kidney Transplant Recipients Show a Reduced Capacity to Produce Cytokines But Retain Their Cytotoxic Capacity
The role of NK cells in either graft rejection or tolerance induction is still discussed controversially. In order to clarify the effect of long-term immunosuppression…2015 American Transplant Congress
Pharmacokinetics of Everolimus (EVL) in Elderly Recipients Under Low-Tacrolimus(TAC)/Everolimus in the First Year After Renal Transplantation. Data from the NEverOLd Trial
Elderly ( >60 years) recipients are being renal transplanted more frequently. The pharmacokinetics studies (PK) of immunosuppressive drugs in healthy volunteers, rarely, if ever, include…
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