ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Outcome of Kidney Transplantation from Obese Living Donors: Histological Evaluation Using Zero-Time Biopsy Specimens

    K. Omoto,1 D. Toki,1 M. Okumi,1 T. Shimizu,1 H. Ishida,1 K. Honda,2 J. Koike,3 K. Tanabe.1

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan; 3Department of Pathology, St. Marianna University, School of Medicine, Kawasaki, Japan.

    BACKGROUND AND OBJECTIVE: The relationship between preimplantation biopsy and graft outcome in kidney transplantation from obese living donors has not been studied. We reviewed graft…
  • 2015 American Transplant Congress

    Lung Transplantation (LTx) in Patients on Extracorporeal Support – Is It a Bridge Too Far? A Single Centre Cohort Analysis

    B. Zych, D. Garcia-Saez, P. Mohite, A. Reed, F. De Robertis, A. Popov, M. Amrani, T. Bahrami, N. Patil, M. Carby, A. Simon.

    Department of Cardio-Thoracic Transplantation & Mechanical Circulatory Support, Harefield Hospital. Royal Brompton & Harefield NHS Foundation Trust, Harefield, Middlesex, United Kingdom.

    Objective: LTx in patients remaining on extracorporeal support is still controversial approach despite good results published by leading transplant centres. In this study we evaluate…
  • 2015 American Transplant Congress

    Change in Frailty Between Evaluation for Kidney Transplantation and Transplantation

    M. McAdams DeMarco, E. King, N. Desai, N. Dagher, B. Lonze, R. Montgomery, D. Segev.

    Johns Hopkins, Baltimore, MD.

    BACKGROUND: Frailty prevalence is high and predicts early hospital readmission, length of stay and mortality in adults of all ages undergoing kidney transplantation (KT). The…
  • 2015 American Transplant Congress

    Are DQA Antibodies Real?

    J. Jones, D. Lucas, M. Leffell, A. Zachary.

    Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

    Antibodies specific for HLA-DQ antigens appear to be increasing in frequency in the post-transplant period and are difficult to reduce effectively with desensitization protocols using…
  • 2015 American Transplant Congress

    Influence of POR*28 Genotype on Tacrolimus Disposition in Heart Transplant Recipients

    T. Alford,1 R. Page,1 J. Lindenfeld,2 C. Aquilante.1

    1University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO; 2University of Colorado School of Medicine, Aurora, CO.

    Polymorphisms in P450 oxidoreductase (POR) have been shown to modulate CYP3A activity and alter the pharmacokinetics of CYP3A substrates, such as tacrolimus (TAC). The objective…
  • 2015 American Transplant Congress

    Identification of Genetic Variants Associated With Variation of Tacrolimus Levels in African Americans Using GWAS

    W. Oetting,1 D. Schladt,2 W. Guan,1 A. Israni,2 R. Remmel,1 C. Dorr,2 K. Sanghavi,1 R. Mannon,3 B. Herrera,4 A. Matas,1 D. Salomon,5 P. Kwok,4 P. Jacobson,1 for DeKAF Genomics.1

    1Univ. of Minnesota, Minneapolis; 2Minneapolis Medical Research Foundation, Minneapolis; 3Univ. of Alabama, Birmingham; 4Univ. of California, San Francisco; 5Scripps Research Center, La Jolla.

    African American kidney transplant recipients (AA) have a higher incidence of allograft failure when compared to Caucasians. We have previously reported that tacrolimus troughs (TT)…
  • 2015 American Transplant Congress

    Immunological Evaluation of Acellular Extracellular Matrix Upon Transplantation

    M. Ketaki,1 P. Pradeep,1 N. Nikhil,1 G. Dellgren,3 H. Suchitra, M. Olausson.2

    1Laboratory for Transplantation Regenerative Medicine, Surgery, Gothenburg University, Gothenburg, Sweden; 2Department of Surgery, SU/Sahlgrenska University Hospital, SE 41345, Gothenburg, Sweden; 3Cardiothoracic Surgery, Transplant Institute, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.

    Background : To mitigate the scanty supply of donor organs, porcine tissues can be utilized since, it embrace the potential to accomplish the task of…
  • 2015 American Transplant Congress

    Microchimerism-Tolerance “Missing Link”: Exosome Acquisition by Host Dendritic Cells

    W. Bracamonte-Baran, E. Jankowska-Gan, Y. Zhou, W. Burlingham.

    Surgery, University of Wisconsin, Madison, WI.

    Background: widespread maternal microchimerism (MMc) in mice is associated with development of immune regulation, which can be used to predict transplantation tolerance. We recently showed…
  • 2015 American Transplant Congress

    Donor Dendritic Cells – Potential New Therapeutic Target in Transplantation

    T. Ueno,1,2,3 M. Yeung,1 M. McGrath,1 H. Iwamoto,3 Y. Nakamura,3 O. Konnno,3 Y. Kihara,3 T. Yokoyama,3 S. Ono,3 T. Ikeda,3 S. Kawachi,3 B. Ibrahim,1 A. Chandraker.1

    1Renal, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; 2Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; 3Transplant Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan.

    Background: It is clear that T cells play a central role in the process of allograft rejection. However, donor dendritic cells (dDC) are the most…
  • 2015 American Transplant Congress

    Educating the Less Prepared: Transplant Knowledge and Decision-Making Differences by Race at Onset of Evaluation

    A. Waterman,1 J. Peipert,1 S. Brann,2 C. Kynard-Amerson,1 M. Robbins,3 A. Paiva,3 A. Gaber.2

    1David Geffen School of Medicine, UCLA, Los Angeles, CA; 2Methodist J.C. Walter Jr. Transplant Center, Houston, TX; 3University of Rhode Island, Kingston, RI.

    Racial minorities have higher rates of kidney failure than Whites but are less likely to receive kidney transplants. This study described each race/ethnic groups' level…
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