ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Renal Function Following Basiliximab Induction in Liver Transplant Recipients

    J. Hagopian, T. Horwedel, L. Bowman, K. Collins, M. Doyle.

    Washington University School of Medicine, St. Louis.

    Purpose: Reports of the use of antibody induction to delay the start of calcineurin inhibitor therapy postoperatively in patients with renal insufficiency at the time…
  • 2015 American Transplant Congress

    Incidence and Risk Factors for Infectious Complications in Liver Transplant Patients Converted to Everolimus

    A. Islam,1 J. DeVos,2 L. Teeter,3 E. Graviss,3 S. Gordon-Burroughs,1 A. Saharia,1 C. Mobley,1 A. Gaber,1 R. Ghobrial.1

    1Department of Surgery, Houston Methodist Hospital, Houston, TX; 2Department of Pharmacy, Houston Methodist Hospital, Houston, TX; 3Department of Pathology & Genomic Medicine, Houston Methodist Hospital, Houston, TX.

    AIM:Immunosuppression with an mTOR inhibitor plus calcineurin inhibitor (CNI) minimization is increasingly used in liver transplantation to protect against the nephrotoxic and neurotoxic side effects…
  • 2015 American Transplant Congress

    Financial Impact of an Advanced Liver Disease Service on a Tertiary Health System

    A. Masoumi,1 S. Hanish,2 J. LaMattina,2 C. Njoka,1 W. Hutson,2 D. Potosky,2 R. Barth.2

    1University of Maryland Medical Center, Baltimore; 2University of Maryland School of Medicine, Baltimore.

    Regional disparities in liver transplantation motivated revision of national organ-sharing policies towards critically ill patients. Liver transplantation of high MELD patients incorporates significant institutional commitment…
  • 2015 American Transplant Congress

    Human CD8+TCR– Facilitating Cells Enhance HSC Engraftment In Vivo and Promote HSC Survival In Vitro

    Y. Huang,1 M. Elliott,1 E. Yolcu,1 T. Miller,1 L. Bozulic,2 Y. Wen,1 H. Xu,1 S. Ildstad.1,2

    1Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; 2Regenerex, LLC, Louisville, KY.

    CD8+/TCR- facilitating cells (FC) in mouse BM significantly enhance engraftment of hematopoietic stem cells (HSC) in syngeneic and allogeneic recipients. Human FC phenotype and mechanism…
  • 2015 American Transplant Congress

    Targeted Rapamycin Nanotherapy Dampens Memory T Cell Function

    S. Nadig,1 S. Esckilsen,1 A.-M. Broome,2 S. Dixit,2 C. Atkinson.3

    1Surgery, Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; 2Radiologic Sciences, Medical University of South Carolina, Charleston, SC; 3Microbiology and Immunology, Medical University of South Carolina, Charleston, SC.

    Memory T cells (Tm) are difficult to control post-transplantation and account for early rejection episodes. Additionally, therapies exerting local immunosuppression by targeting an allograft, while…
  • 2015 American Transplant Congress

    Prevalence and Clinical Outcomes Associated With Vancomycin-Resistant Enterococcal Colonization Or Infection After Small Intestinal Transplantation

    N. Shah,1 L. Nabha,2 R. Teran,3 C. Matsumoto,4 R. Farney,5 P. Kumar,6 J. Timpone.7

    1Infectious Diseases, MEDSTAR Georgetown University Hospital, Washington, DC; 2Infectious Diseases, MEDSTAR Georgetown University Hospital, Washington, DC; 3Infectious Diseases, MEDSTAR Georgetown University Hospital, Washington, DC; 4MEDSTAR Georgetown Transplant Institute, MEDSTAR Georgetown University Hospital, Washington, DC; 5Infectious Diseases, MEDSTAR Georgetown University Hospital, Washington, DC; 6Infectious Diseases, MEDSTAR Georgetown University Hospital, Washington, DC; 7Infectious Diseases, MEDSTAR Georgetown University Hospital, Washington, DC.

    BACKGROUND: Vancomycin-resistant enterococcal (VRE) infections cause significant morbidity and mortality amongst SOT recipients. However, little is known about the relevance of VRE in small intestinal…
  • 2015 American Transplant Congress

    Evaluating the Benefits of Everolimus on Cardiac Allograft Vasculopathy: Further Evidence from Results of Imputations for Missing IVUS Data from A2310 Study

    P. Lopez,1 G. Dong,2 Z. Wang.2

    1Novartis Pharma AG, Basel, Switzerland; 2Novartis Pharmaceuticals, East Hanover, NJ; 3Novartis Pharmaceuticals, East Hanover, NJ.

    Purpose: A2310 IVUS study showed that everolimus (EVR) provides cardiac allograft vasculopathy (CAV) benefit compared to mycophenolate mofetil (MMF) by assessing the mean change in…
  • 2015 American Transplant Congress

    The Outcome of Carbapenemase-Producing Enterobacteriaceae (CPE) Infection in Adult Solid Organ Transplant Population at a University Teaching Hospital

    H. Sharma, A. El-Bakry, V. Venkat, S. Papachristos, P. Otilla, R. Dhanda, B. Forgacs, A. Tavakoli, R. Pararajasingam.

    Transplant Surgery, Manchester Royal Infirmary, Manchester, United Kingdom.

    BACKGROUND:Over the last decade CPE infection has been reported globally and is now endemic in healthcare facilities in many countries. There has been no report…
  • 2015 American Transplant Congress

    Pancreatic Islet Survival Under Confinement

    A. Rodriguez, S. Sigrist, E. Maillard.

    UMR DIATHEC EA 7294, Centre Européen d'Etude du Diabète, Strasbourg, France.

    The main advantage of cell therapy is the possibility to immune-isolate the graft in a device to avoid immune suppressive regimen. In islet transplantation field,…
  • 2015 American Transplant Congress

    Immune Rejection of iPS Cells Is Triggered By Gamete-Associated Proteins (GAPs)

    E.-M. Kim, G. Manzar, N. Zavazava.

    Internal Medicine, University of Iowa, Iowa City, IA; Internal Medicine, University of Iowa, Iowa City, IA; Internal Medicine, University of Iowa, Iowa City, IA.

    Induced pluripotent stem (iPS) cells have emerged as a new source for cell based therapies. However, the safety of iPS cells in autologous recipients has…
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