Am J Transplant, Volume 5, Suppl 3 Archives - ATC Abstracts

2015 American Transplant Congress
Is BMI of 28 an Appropriate Cutoff for Simultaneous Pancreas Kidney Transplant in Type II Diabetes?
E. Ahmed, D. Bruce, I. Carmody, A. Cohen, G. Loss, T. Reichman, J. Seal, H. Bohorquez.
Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA.
In simultaneous pancreas and kidney (SPK) transplantation, obesity has been reported to be associated with inferior survival and increased post-transplant complications. With implementation of the…
2015 American Transplant Congress
Variables Related to the Development of Donor Specific Antibodies (DSA) Post-Kidney Transplant (KTx): Implications for Late Graft Histology and Survival
F. Cosio,¹ C. Schinstock,¹ M. Stegall.²
¹Medicine, Mayo Clinic, Rochester, MN; ²Surgery, Mayo Clinic, Rochester, MN.
Introduction. The incidence of de novo DSA increases post-KTx. DSA is associated to reduced graft survival likely due to chronic antibody mediated rejection (cAMR). However,…
2015 American Transplant Congress
National Outcomes of Kidney Tranplantation from Diabetic Donors: A Mate-Kidney Analysis
J. Cohen,¹ P. Reese,¹ P. Porrett,² R. Bloom,¹ K. Forde,³ D. Sawinski.¹
¹Renal Division, Univ. of Penn, Philadelphia, PA; ²Dept of Surgery, Univ. of Penn, Philadelphia, PA; ³Division of Gastroenterology, Univ. of Penn, Philadelphia, PA.
Utilization of diabetic donor kidneys has increased, though scarce patient and allograft survival data are available for recipients of these organs. Using United Network for…
2015 American Transplant Congress
Estimation of Glomerular Filtration Rate With Serum Cystatin C Accurately Discriminates Renal Dysfunction in Liver Transplant Candidates With End-Stage Liver Disease
S. Gonzalez,¹ J. Trotter,¹ H. Szerlip,² M. Levy,³ A. Chandrakantan,⁴ A. Yango,⁴ A. Rajagopal,⁴ Y. Barri,⁴ K. Rice,⁴ M. Saim,² L. Melton,⁴ M. Emmett,² G. Klintmalm,³ B. Fischbach.⁴
¹Hepatology, Baylor Simmons Transplant Institute, Fort Worth, TX; ²Nephrology, Baylor University Medical Center, Dallas, TX; ³Transplant Surgery, Baylor Simmons Transplant Institute, Fort Worth, TX; ⁴Nephrology, Baylor Simmons Transplant Institute, Fort Worth, TX.
Background: Renal insufficiency is common in end-stage liver disease (ESLD) and is linked to survival in patients awaiting liver transplantation. Serum creatinine correlates poorly with…
2015 American Transplant Congress
Desensitization With Costimulation Blockade and Proteasome Inhibition in a Non-Human Primate Model of Kidney Transplantation
C. Burghuber,^1,2 J. Kwun,¹ E. Page,¹ A. Gibby,¹ F. Leopardi,³ A. Farris,¹ N. Iwakoshi,¹ S. Knechtle.^1,3
¹Emory Translant Center, Emory University, Atlanta, GA; ²Medical University Vienna, Vienna, Austria; ³Duke University, Durham, NC.
[Background] Sensitization is a growing problem on the kidney waiting list. Alloantibody can significantly deteriorate graft survival. Currently used desensitization strategies are time-consuming, expensive and…
2015 American Transplant Congress
Part II: Rates and Determinants of Progression for De Novo Donor-Specific Antibody Mediated Kidney Allograft Injury
C. Wiebe,^1,2 I. Gibson,³ D. Pochinco,² P. Birk,⁴ T. Blydt-Hansen,⁴ J. Ho,^1,5 M. Karpinski,¹ A. Goldberg,⁴ L. Storsley,¹ D. Rush,¹ P. Nickerson.^1,2,5
¹Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Immunogenetics, Diagnostic Services of Manitoba, Winnipeg, MB, Canada; ³Pathology, University of Manitoba, Winnipeg, MB, Canada; ⁴Pediatric and Child Health, University of Manitoba, Winnipeg, MB, Canada; ⁵Immunology, University of Manitoba, Winnipeg, MB, Canada.
The development of de novo donor-specific antibody (dnDSA) is an independent predictor of allograft loss in renal transplantation. Rates and determinants of clinical pathologic progression…
2015 American Transplant Congress
Muscle Mass Measurement Is Objective and More Predictive of Expected Mortality Than Functional Status in High MELD Liver Transplant Recipients
J. Nolte,¹ S. Gordon Burroughs,¹ D. Victor,¹ C. Mobley,¹ N. Yu,² T. Hirase,¹ A. Saharia,¹ A. Rajaraman,¹ L. Moore,¹ A. Gaber,¹ R. Ghobrial.¹
¹Surgery, Houston Methodist Hospital, Houston, TX; ²Radiology, Houston Methodist Hospital, Houston, TX.
Introduction: Calculations used to determine expected survival post-liver transplant (OLT) are in part based on pre-OLT functional status. Functional status is subjectively measured by Karnofsky…
2015 American Transplant Congress
Is Pretransplant Anti-A/B Antibody Removal Prerequisite for Successful ABO Incompatible Kidney Transplantation in Children?
S. Shishido,¹ T. Kawamura,¹ Y. Hamasaki,² Y. Takahashi,¹ Y. Hyodo,¹ Y. Itabashi,¹ H. Nihei,¹ T. Yonekura,¹ Y. Inaba,² Y. Yoshida,² K. Sakai,¹ A. Aikawa.¹
¹Nephrology, Toho University, School of Medicine, Tokyo, Japan; ²Pediatric Nephrology, Too University, School of Medicine, Tokyo, Japan.
Purpose: We have recently demonstrated that the long-term outcome of ABO incompatible living donor kidney transplantation (ABOiKT) in children was comparable to those of ABO…
2015 American Transplant Congress
Tracking T Cell Fate After Antithymocyte Globulin (ATG) Immunotherapy in Infant Heart Transplant (HTx) Patients
S.-I. Wang,^1,2 I. Larsen,^1,2 S. Urschel,^1,2 R. Chinnock,³ J. Rusch,³ L. West.^1,2
¹Univ. of Alberta, Edmonton, Canada; ²Alberta Transplant Institute, Edmonton, Canada; ³Loma Linda Univ., Loma Linda.
Polyclonal T cell depletion with ATG is a common induction therapy in adult and pediatric transplantation. In adults, T cell recovery post-ATG involves homeostatic proliferation…
2015 American Transplant Congress
Pre-Transplant Anti-LG3 Antibodies Enhance Allograft Dysfunction in Kidney Transplant Recipients With Delayed or Slow Graft Function
H. Cardinal, M. Hénault-Rondeau, S. Morissette, K. Hamelin, M.-J. Hébert.
CHUM Research Center, Montreal, Canada.
Background: We have previously shown that autoantibodies to the LG3 fragment of perlecan enhance vascular damage in a murine model of vascular rejection, particularly when…

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