ATC Abstracts

American Transplant Congress abstracts

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  • 2015 American Transplant Congress

    Microchimerism-Tolerance “Missing Link”: Exosome Acquisition by Host Dendritic Cells

    W. Bracamonte-Baran, E. Jankowska-Gan, Y. Zhou, W. Burlingham.

    Surgery, University of Wisconsin, Madison, WI.

    Background: widespread maternal microchimerism (MMc) in mice is associated with development of immune regulation, which can be used to predict transplantation tolerance. We recently showed…
  • 2015 American Transplant Congress

    Donor Dendritic Cells – Potential New Therapeutic Target in Transplantation

    T. Ueno,1,2,3 M. Yeung,1 M. McGrath,1 H. Iwamoto,3 Y. Nakamura,3 O. Konnno,3 Y. Kihara,3 T. Yokoyama,3 S. Ono,3 T. Ikeda,3 S. Kawachi,3 B. Ibrahim,1 A. Chandraker.1

    1Renal, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; 2Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; 3Transplant Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan.

    Background: It is clear that T cells play a central role in the process of allograft rejection. However, donor dendritic cells (dDC) are the most…
  • 2015 American Transplant Congress

    Educating the Less Prepared: Transplant Knowledge and Decision-Making Differences by Race at Onset of Evaluation

    A. Waterman,1 J. Peipert,1 S. Brann,2 C. Kynard-Amerson,1 M. Robbins,3 A. Paiva,3 A. Gaber.2

    1David Geffen School of Medicine, UCLA, Los Angeles, CA; 2Methodist J.C. Walter Jr. Transplant Center, Houston, TX; 3University of Rhode Island, Kingston, RI.

    Racial minorities have higher rates of kidney failure than Whites but are less likely to receive kidney transplants. This study described each race/ethnic groups' level…
  • 2015 American Transplant Congress

    Validating Outcomes Reported to the Organ Procurement and Transplantation Network for Deceased Donor Kidney Recipients

    V. Potluri,1 C. Parikh,2 I. Hall,2 J. Ficek,2 M. Doshi,3 I. Butrymowicz,2 F. Weng,4 B. Schröppel,5 H. Thiessen-Philbrook,6 P. Reese.7

    1Lankenau Hospital, Philadelphia; 2Yale University School of Medicine, New Haven; 3Wayne State University, Detroit; 4Barnabas Health, Livingston, NJ; 5University Hospital, Ulm, Germany; 6Western University, Ontario, Canada; 7University of Pennsylvania, Philadelphia.

    Data reported to the Organ Procurement and Transplantation Network (OPTN) is used in kidney transplant research, quality metrics and in policy development, but the accuracy…
  • 2015 American Transplant Congress

    Prospective, 6 Month, Open Label, Conversion Study from Mycophenolate Mofetyl to Mycophenolic Acid Evaluating the Severity of Gastro-Intestinal Symptoms and Mycophenolic Acid Urinary Metabolite as a Surrogate Marker of Plasmatic Area Under the Curve

    D. Tran,1 A. Boucher,1 L. Senécal,1 V. Pichette,1 F. Leblond,2 S. Collette.1

    1Nephrology, Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada; 2Research Center, Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.

    Introduction: Treatment with mycophenolate mofetil (MMF) often results in adverse gastro-intestinal (GI) events, which can lead to dose reductions that in turn can increase the…
  • 2015 American Transplant Congress

    Outbreak of Pandemic Influenza A (H1N1pdm) in a Kidney Transplant Unit – The Protective Effect of Vaccination

    I. Helanterä,1 V.-J. Anttila,2 M. Lappalainen,3 M. Lempinen,1 H. Isoniemi.1

    1Department of Transplant and Liver Surgery, Helsinki University Central Hospital, Helsinki, Finland; 2Department of Infectious Diseases, Helsinki University Central Hospital, Helsinki, Finland; 3Department of Virology, Helsinki University Central Hospital, Helsinki, Finland.

    Background: Seasonal influenza vaccination is recommended for patients with end-stage renal disease, although the efficacy of the vaccination among these patients is unknown. We characterize…
  • 2015 American Transplant Congress

    Deceased Donor HLA Antibody Incompatible Renal Transplantation Without Antibody Removal: High Incidence of Acute Rejection Reduced By T-Cell Depleting Induction Therapy

    E. Jolly,1 C. Taylor,2 H. Morgan,2 S. Peacock,2 M. Clatworthy,1 N. Torpey.1

    1Division of Renal Medicine, Department of Medicine, University of Cambridge, Cambridge, United Kingdom; 2Tissue Typing Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.

    Aims: Screening for HLA-specific antibodies (Ab) is routine for patients on kidney transplant waiting lists, and HLA antigens to which a patient has detectable Ab…
  • 2015 American Transplant Congress

    Consideration of the Futility of Transplant: 50% Mortality at 5 Years

    S. Asrani, G. Saracino, J. O'Leary, G. Klintmalm, J. Trotter.

    Baylor University Medical Center, Dallas, TX.

    Introduction: Transplant recipients are globally sicker at the time of liver transplantation (LT) in the current era. We sought to devise and validate a model…
  • 2015 American Transplant Congress

    Preventing Cytomegalovirus Infection in Intermediate-High Risk Liver Transplant Recipients: Acyclovir Vs Valganciclovir

    S. Dulanya, A. Anamisis, D. Tsapepas.

    Department of Pharmacy, New York Presbyterian Hospital, New York City, NY.

    Cytomegalovirus (CMV) is an opportunistic infection responsible for profound morbidity and mortality among solid organ transplant recipients. A donor and recipient's CMV IgG serostatus influences…
  • 2015 American Transplant Congress

    Birth Weight as a Marker of Nephron Mass: Predicting Living Kidney Donor Outcomes

    T. Schachtner,1,2 P. Reinke.1,2

    1Nephrology and Internal Intensive Care, Charité Campus Virchow Clinic, Berlin, Germany; 2Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany.

    It has been demonstrated that low birth weights give rise to a reduction in nephron number and low glomerular size in the postnatal kidney. Oligonephropathy…
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