Am J Transplant, Volume 5, Suppl 3 Archives - ATC Abstracts

2015 American Transplant Congress
Muscle Mass Measurement Is Objective and More Predictive of Expected Mortality Than Functional Status in High MELD Liver Transplant Recipients
J. Nolte,¹ S. Gordon Burroughs,¹ D. Victor,¹ C. Mobley,¹ N. Yu,² T. Hirase,¹ A. Saharia,¹ A. Rajaraman,¹ L. Moore,¹ A. Gaber,¹ R. Ghobrial.¹
¹Surgery, Houston Methodist Hospital, Houston, TX; ²Radiology, Houston Methodist Hospital, Houston, TX.
Introduction: Calculations used to determine expected survival post-liver transplant (OLT) are in part based on pre-OLT functional status. Functional status is subjectively measured by Karnofsky…
2015 American Transplant Congress
Is Pretransplant Anti-A/B Antibody Removal Prerequisite for Successful ABO Incompatible Kidney Transplantation in Children?
S. Shishido,¹ T. Kawamura,¹ Y. Hamasaki,² Y. Takahashi,¹ Y. Hyodo,¹ Y. Itabashi,¹ H. Nihei,¹ T. Yonekura,¹ Y. Inaba,² Y. Yoshida,² K. Sakai,¹ A. Aikawa.¹
¹Nephrology, Toho University, School of Medicine, Tokyo, Japan; ²Pediatric Nephrology, Too University, School of Medicine, Tokyo, Japan.
Purpose: We have recently demonstrated that the long-term outcome of ABO incompatible living donor kidney transplantation (ABOiKT) in children was comparable to those of ABO…
2015 American Transplant Congress
Tracking T Cell Fate After Antithymocyte Globulin (ATG) Immunotherapy in Infant Heart Transplant (HTx) Patients
S.-I. Wang,^1,2 I. Larsen,^1,2 S. Urschel,^1,2 R. Chinnock,³ J. Rusch,³ L. West.^1,2
¹Univ. of Alberta, Edmonton, Canada; ²Alberta Transplant Institute, Edmonton, Canada; ³Loma Linda Univ., Loma Linda.
Polyclonal T cell depletion with ATG is a common induction therapy in adult and pediatric transplantation. In adults, T cell recovery post-ATG involves homeostatic proliferation…
2015 American Transplant Congress
Pre-Transplant Anti-LG3 Antibodies Enhance Allograft Dysfunction in Kidney Transplant Recipients With Delayed or Slow Graft Function
H. Cardinal, M. Hénault-Rondeau, S. Morissette, K. Hamelin, M.-J. Hébert.
CHUM Research Center, Montreal, Canada.
Background: We have previously shown that autoantibodies to the LG3 fragment of perlecan enhance vascular damage in a murine model of vascular rejection, particularly when…
2015 American Transplant Congress
Post-Kidney Transplant Infections in Desensitized Patients Receiving Thymoglobulin or Daclizumab Induction: Results of a Randomized Clinical Trial
B. Orandi,¹ J. Locke,² E. Kraus,³ B. Lonze,¹ N. Desai,¹ N. Dagher,¹ N. Alachkar,³ C. Simpkins,⁴ F. Naqvi,³ D. Segev,¹ R. Montgomery,¹ R. Avery.³
¹Department of Surgery, Johns Hopkins University, Baltimore; ²Department of Surgery, University of Alabama--Birmingham, Birmingham; ³Department of Medicine, Johns Hopkins University, Baltimore; ⁴Department of Surgery, Dartmouth, Lebanon.
Live donor kidney transplant recipients requiring desensitization for donor-specific antibody, who were enrolled in a single-center randomized trial of thymoglobulin vs. daclizumab induction, were evaluated…
2015 American Transplant Congress
Loss of RIPK3 and Caspase-8 Enhance Intrinsic Apoptosis in Tubular Epithelial Cell (TEC) Death and Contributes to Kidney Ischemia Reperfusion Injury (IRI)
B. Sung,¹ Y. Su,³ A. Lau,³ J. Jiang,³ A. Haig,² D. Green,⁴ Z. Zhang,² A. Jevnikar.¹
¹Microbiology and Immunology, Western University, London, ON, Canada; ²Pathology, Western University, London, ON, Canada; ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ⁴St. Jude Children's Research Hospital, Memphis, TN.
[Background] Ischemia-reperfusion injury (IRI), a complex limiting factor in organ transplant survival, is related to multiple death pathways. Eliminating the key necroptotic molecule (RIPK3) improves…
2015 American Transplant Congress
Outpatient Management of Delayed Graft Function (DGF) Is Associated With Reduced Length of Stay and Acute Rejection
B. Muth,¹ B. Astor,¹ J. Turk,¹ M. Mohamed,¹ S. Parajuli,¹ D. Kaufman,² D. Mandelbrot,¹ A. Djamali.^1,2
¹Department of Medicine, University of Wisconsin, Madison, WI; ²Department of Surgery, University of Wisconsin, Madison, WI.
Delayed graft function (DGF) increases hospital length of stay (LOS) and risk for readmission, rejection, early graft loss and death. We created a multidisciplinary DGF…
2015 American Transplant Congress
Safety and Efficacy of All Oral DAA Therapy for Genotype 1 HCV Post-Liver Transplant: Interval Results from the HCV-TARGET Multicenter Prospective Observational Study
J. O'Leary,¹ R. Brown,² K. Reddy,³ A. Kuo,⁴ G. Morelli,⁵ R. Stravitz,⁶ G. Everson,⁷ C. Durand,⁸ H. Vargas,⁹ P. Kwo,¹⁰ C. Frenette,¹¹ J. Peter,¹² M. Vainorius,¹² L. Akushevich,¹² D. Nelson,⁵ M. Fried,¹² N. Terrault.¹³
¹Baylor University Medical Center, TX; ²Columbia University, NY; ³University of Pennsylvania, PA; ⁴UCSD, CA; ⁵University of Florida, Gainesville, Gainesville, FL; ⁶Virginia Commonwealth University, VA; ⁷University of Colorado, CO; ⁸Johns Hopkins, MD; ⁹Mayo Clinic, AZ; ¹⁰Indiana University, IL; ¹¹Scipps Clinic, CA; ¹²University of North Carolina, NC; ¹³UCSF, CA.
The safety and efficacy of direct-acting antivirals (DAA) for HCV post-LT remain unknown. METHODS: We describe the safety and efficacy of all oral DAA-therapy for…
2015 American Transplant Congress
Six Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Mismatched Living Donor Renal Transplant Recipients
J. Leventhal, M. Abecassis, L. Gallon, J. Galvin, J. Mehta, K. Ravindra, D. Tollerud, M. Elliott, S. Ildstad.
Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, IL; Duke University, Durham, NC; Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; Regenerex, LLC, Louisville, KY.
27 subjects have been transplanted in a phase 2 protocol (IDE 13947) based upon tolerogenic CD8+/TCR- facilitating cells (FCRx) and 200 cGy TBI-based nonmyeloablative conditioning…
2015 American Transplant Congress
Hepatic Stellate Cells Directly Inhibit B Cells Via PD-L1
Y. Li, K. Fang, S. Qian, J. Fung, L. Lu, F. Lin.
Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Hepatic stellate cells (HSCs) account for one third of the nonparenchymal cells in the liver, which are considered to be critical in maintaining the immunoprivileged…

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