2013 American Transplant Congress
Early BK Viremia Is Associated with Antibodies to Kidney Transplant-Associated Self-Antigens Collagen Type IV and Fibronectin
PURPOSE: BK virus nephropathy, alloimmunity and autoimmune disease are important complications after kidney transplantation. We recently demonstrated that antibodies to kidney transplant-associated self-antigens (TSA) such…2013 American Transplant Congress
Hyperglycemia Augments Inflammatory Immune Responses in Liver Ischemia Reperfusion Injury (IRI) Via the RhoA/Akt Pathway
Background and Aim: With increased numbers of diabetic transplant patients, both pre- and post-transplantation, our understanding of how hyperglycemia regulates immunity is imperative. We studied…2013 American Transplant Congress
Single Center Experience of ABO-Incompatible Liver Transplantation
Transplant Surgery, Beth Israel Deaconess Medical Center, Boston, MA
The shortage of available deceased donor liver allografts remains a problem in multiple regions of the country. UNOS allows wait-listed patients with MELD scores greater…2013 American Transplant Congress
Complex Host MicroRNA Response to Cytomegalovirus Infection: A Bench to Bedside Analysis, A
Background:Human microRNAs (hsa-miRNA) bind to target-mRNAs inhibiting protein translation. We hypothesized that the host response to CMV includes hsa-miRNAs that specifically down- or up-regulate virus…2013 American Transplant Congress
Pediatric Steroid-Free Deceased-Donor Renal Transplantation with Alemtuzamab Induction: A Seven-Year Experience
INTRODUCTION AND OBJECTIVES: Alemtuzumab (Campath-1H, C1H) is a monoclonal antibody targeting CD52 receptors on B- and T-lymphocytes and is an effective induction agent in renal…2013 American Transplant Congress
Five Year Survival and Graft Function with the Clinical Use of Gene Expression Profiling for Rejection Surveillance
Purpose: Gene expression profiling (GEP) offers a non-invasive alternative to surveillance with endomyocardial biopsies. We sought to assess the medium-term survival and graft function in…2013 American Transplant Congress
Effects of Various Therapeutic Levels of Tacrolimus on Early Post Transplant Outcomes
University of Florida, Gainesville
Background: In striving to achieve early tacrolimus therapeutic levels, there is a risk of overshooting and achieving supratherapeutic or toxic levels. We studied our patients…2013 American Transplant Congress
Phosphatase and Tensin Homolog (PTEN) Promotes Liver Pro-Inflammatory Immune Response Against Ischemia Reperfusion Injury (IRI)
Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA
Background and Aim: The PI3 kinase-Akt-Gsk3 pathway is involved in both immune regulation and hepatocyte proliferation/death in inflammatory liver diseases. PTEN is a negative regulator…2013 American Transplant Congress
Sarcopenia Is Not Related to Quality of Life in Liver Transplant Candidates
Patients with end stage liver disease (ESLD) suffer from malnutrition and skeletal muscle wasting. In patients awaiting liver transplantation (LT), sarcopenia (loss of muscle mass…2013 American Transplant Congress
CMV Vaccine Prevents Accelerated Chronic Rejection in CMV-Naive Recipients of Infected Allograft Hearts
Surgery, OHSU, Portland, OR; VGTI, OHSU, Beaverton, OR
CMV infection accelerates transplant vascular sclerosis (TVS) and chronic rejection (CR) in solid organ transplants. Recipients of latently HCMV infected donor grafts are at highest…
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